Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development
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| Title: | Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development |
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| Language: | English |
| Authors: | Wiggins, Lisa D., Tian, Lin H., Levy, Susan E., Rice, Catherine, Lee, Li-Ching, Schieve, Laura, Pandey, Juhi, Daniels, Julie, Blaskey, Lisa, Hepburn, Susan, Landa, Rebecca, Edmondson-Pretzel, Rebecca, Thompson, William |
| Source: | Journal of Autism and Developmental Disorders. Nov 2017 47(11):3634-3645. |
| Availability: | Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com |
| Peer Reviewed: | Y |
| Page Count: | 12 |
| Publication Date: | 2017 |
| Sponsoring Agency: | Centers for Disease Control and Prevention (DHHS/PHS) |
| Contract Number: | U10DD000180 U10DD000181 U10DD000182 U10DD000183 U10DD000184 U10DD000498 |
| Document Type: | Journal Articles Reports - Research |
| Education Level: | Early Childhood Education |
| Descriptors: | Young Children, Autism, Pervasive Developmental Disorders, Homogeneous Grouping, Child Development, Diagnostic Tests, Disability Identification, Delayed Speech, Developmental Delays, Psychomotor Skills, Genetics, Early Childhood Education |
| DOI: | 10.1007/s10803-017-3280-4 |
| ISSN: | 0162-3257 |
| Abstract: | The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: "mild language delay with cognitive rigidity," "mild language and motor delay with dysregulation," "general developmental delay," and "significant developmental delay with repetitive motor behaviors." We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed. |
| Abstractor: | As Provided |
| Number of References: | 50 |
| Entry Date: | 2017 |
| Accession Number: | EJ1156821 |
| Database: | ERIC |
| Abstract: | The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: "mild language delay with cognitive rigidity," "mild language and motor delay with dysregulation," "general developmental delay," and "significant developmental delay with repetitive motor behaviors." We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed. |
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| ISSN: | 0162-3257 |
| DOI: | 10.1007/s10803-017-3280-4 |
