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Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development

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Title: Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development
Language: English
Authors: Wiggins, Lisa D., Tian, Lin H., Levy, Susan E., Rice, Catherine, Lee, Li-Ching, Schieve, Laura, Pandey, Juhi, Daniels, Julie, Blaskey, Lisa, Hepburn, Susan, Landa, Rebecca, Edmondson-Pretzel, Rebecca, Thompson, William
Source: Journal of Autism and Developmental Disorders. Nov 2017 47(11):3634-3645.
Availability: Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
Peer Reviewed: Y
Page Count: 12
Publication Date: 2017
Sponsoring Agency: Centers for Disease Control and Prevention (DHHS/PHS)
Contract Number: U10DD000180
U10DD000181
U10DD000182
U10DD000183
U10DD000184
U10DD000498
Document Type: Journal Articles
Reports - Research
Education Level: Early Childhood Education
Descriptors: Young Children, Autism, Pervasive Developmental Disorders, Homogeneous Grouping, Child Development, Diagnostic Tests, Disability Identification, Delayed Speech, Developmental Delays, Psychomotor Skills, Genetics, Early Childhood Education
DOI: 10.1007/s10803-017-3280-4
ISSN: 0162-3257
Abstract: The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: "mild language delay with cognitive rigidity," "mild language and motor delay with dysregulation," "general developmental delay," and "significant developmental delay with repetitive motor behaviors." We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed.
Abstractor: As Provided
Number of References: 50
Entry Date: 2017
Accession Number: EJ1156821
Database: ERIC
FullText Links:
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PubType: Academic Journal
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  Data: Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development
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  Data: <searchLink fieldCode="AR" term="%22Wiggins%2C+Lisa+D%2E%22">Wiggins, Lisa D.</searchLink><br /><searchLink fieldCode="AR" term="%22Tian%2C+Lin+H%2E%22">Tian, Lin H.</searchLink><br /><searchLink fieldCode="AR" term="%22Levy%2C+Susan+E%2E%22">Levy, Susan E.</searchLink><br /><searchLink fieldCode="AR" term="%22Rice%2C+Catherine%22">Rice, Catherine</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Li-Ching%22">Lee, Li-Ching</searchLink><br /><searchLink fieldCode="AR" term="%22Schieve%2C+Laura%22">Schieve, Laura</searchLink><br /><searchLink fieldCode="AR" term="%22Pandey%2C+Juhi%22">Pandey, Juhi</searchLink><br /><searchLink fieldCode="AR" term="%22Daniels%2C+Julie%22">Daniels, Julie</searchLink><br /><searchLink fieldCode="AR" term="%22Blaskey%2C+Lisa%22">Blaskey, Lisa</searchLink><br /><searchLink fieldCode="AR" term="%22Hepburn%2C+Susan%22">Hepburn, Susan</searchLink><br /><searchLink fieldCode="AR" term="%22Landa%2C+Rebecca%22">Landa, Rebecca</searchLink><br /><searchLink fieldCode="AR" term="%22Edmondson-Pretzel%2C+Rebecca%22">Edmondson-Pretzel, Rebecca</searchLink><br /><searchLink fieldCode="AR" term="%22Thompson%2C+William%22">Thompson, William</searchLink>
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  Data: <searchLink fieldCode="SO" term="%22Journal+of+Autism+and+Developmental+Disorders%22"><i>Journal of Autism and Developmental Disorders</i></searchLink>. Nov 2017 47(11):3634-3645.
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  Data: Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
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  Group: SrcInfo
  Data: Y
– Name: Pages
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  Group: Src
  Data: 12
– Name: DatePubCY
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  Data: 2017
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  Data: Centers for Disease Control and Prevention (DHHS/PHS)
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  Data: Journal Articles<br />Reports - Research
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  Data: <searchLink fieldCode="EL" term="%22Early+Childhood+Education%22">Early Childhood Education</searchLink>
– Name: Subject
  Label: Descriptors
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  Data: <searchLink fieldCode="DE" term="%22Young+Children%22">Young Children</searchLink><br /><searchLink fieldCode="DE" term="%22Autism%22">Autism</searchLink><br /><searchLink fieldCode="DE" term="%22Pervasive+Developmental+Disorders%22">Pervasive Developmental Disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Homogeneous+Grouping%22">Homogeneous Grouping</searchLink><br /><searchLink fieldCode="DE" term="%22Child+Development%22">Child Development</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+Tests%22">Diagnostic Tests</searchLink><br /><searchLink fieldCode="DE" term="%22Disability+Identification%22">Disability Identification</searchLink><br /><searchLink fieldCode="DE" term="%22Delayed+Speech%22">Delayed Speech</searchLink><br /><searchLink fieldCode="DE" term="%22Developmental+Delays%22">Developmental Delays</searchLink><br /><searchLink fieldCode="DE" term="%22Psychomotor+Skills%22">Psychomotor Skills</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Early+Childhood+Education%22">Early Childhood Education</searchLink>
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  Data: 10.1007/s10803-017-3280-4
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  Data: 0162-3257
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: "mild language delay with cognitive rigidity," "mild language and motor delay with dysregulation," "general developmental delay," and "significant developmental delay with repetitive motor behaviors." We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed.
– Name: AbstractInfo
  Label: Abstractor
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  Data: As Provided
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  Data: 50
– Name: DateEntry
  Label: Entry Date
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  Data: 2017
– Name: AN
  Label: Accession Number
  Group: ID
  Data: EJ1156821
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=eric&AN=EJ1156821
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        Value: 10.1007/s10803-017-3280-4
    Languages:
      – Text: English
    PhysicalDescription:
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        StartPage: 3634
    Subjects:
      – SubjectFull: Young Children
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      – SubjectFull: Autism
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      – SubjectFull: Pervasive Developmental Disorders
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      – SubjectFull: Homogeneous Grouping
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      – SubjectFull: Child Development
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      – SubjectFull: Diagnostic Tests
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      – SubjectFull: Disability Identification
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      – SubjectFull: Delayed Speech
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      – SubjectFull: Developmental Delays
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      – SubjectFull: Psychomotor Skills
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      – SubjectFull: Genetics
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      – SubjectFull: Early Childhood Education
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      – TitleFull: Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development
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