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Biochemical Screening of Intellectually Disabled and Healthy Children in Punjab, Pakistan: Differences in Liver Function Test and Lipid Profiles

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Title: Biochemical Screening of Intellectually Disabled and Healthy Children in Punjab, Pakistan: Differences in Liver Function Test and Lipid Profiles
Language: English
Authors: Wasim, Muhammad (ORCID 0000-0003-0969-6609), Khan, Haq Nawaz, Ayesha, Hina, Awan, Fazli Rabbi (ORCID 0000-0002-8210-705X)
Source: International Journal of Developmental Disabilities. 2020 66(3):190-195.
Availability: Routledge. Available from: Taylor & Francis, Ltd. 530 Walnut Street Suite 850, Philadelphia, PA 19106. Tel: 800-354-1420; Tel: 215-625-8900; Fax: 215-207-0050; Web site: http://www.tandf.co.uk/journals
Peer Reviewed: Y
Page Count: 6
Publication Date: 2020
Document Type: Journal Articles
Reports - Research
Descriptors: Biochemistry, Screening Tests, Foreign Countries, Metabolism, Genetic Disorders, Clinical Diagnosis, Intellectual Disability, Comparative Analysis, Case Studies, Diseases, Profiles, Preschool Children, Children, Young Adults, Adolescents
Geographic Terms: Pakistan
DOI: 10.1080/20473869.2018.1533084
ISSN: 2047-3869
Abstract: Objectives: Inborn errors of metabolism (IEMs) are rare genetic disorders. Generally, IEMs are untreatable; however, some IEMs causing intellectual disability are potentially treatable if diagnosed earlier. In this study, levels of some clinically important biochemical parameters in intellectually disabled children suspected for IEMs were tested to see their association with intellectual disability, which could be helpful in preliminary screening. Methods: This comparative cross-sectional observational study was carried out from 2014 to 2017. Blood samples from 800 boys and girls (aged 4-24 years) were collected, of which 391 were healthy (IQ >90) and 409 were intellectually disabled (IQ <70) children with unknown cause. Clinically important (Liver and kidney enzymes etc.) biochemical parameters were analyzed in sera samples using commercial kits on semi-automated clinical chemistry analyzer. Results: Serum analysis showed the levels of ALP (p < 0.00001), ASAT (p = 0.001), ALAT (p = 0.016), albumin (p < 0.001), uric acid (p < 0.001), cholesterol (p < 0.001), triglycerides (p < 0.001), and hemoglobin (p = 0.005) were significantly different between healthy and intellectually disabled children. Conclusion: Changes in the liver function test and lipid profile parameters were significantly different in children with intellectual disability; however, it requires further detailed analysis for complete characterization of these diseases.
Abstractor: As Provided
Entry Date: 2020
Accession Number: EJ1255587
Database: ERIC
FullText Text:
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  Data: Biochemical Screening of Intellectually Disabled and Healthy Children in Punjab, Pakistan: Differences in Liver Function Test and Lipid Profiles
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wasim%2C+Muhammad%22&quot;&gt;Wasim, Muhammad&lt;/searchLink&gt; (ORCID &lt;externalLink term=&quot;http://orcid.org/0000-0003-0969-6609&quot;&gt;0000-0003-0969-6609&lt;/externalLink&gt;)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Khan%2C+Haq+Nawaz%22&quot;&gt;Khan, Haq Nawaz&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ayesha%2C+Hina%22&quot;&gt;Ayesha, Hina&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Awan%2C+Fazli+Rabbi%22&quot;&gt;Awan, Fazli Rabbi&lt;/searchLink&gt; (ORCID &lt;externalLink term=&quot;http://orcid.org/0000-0002-8210-705X&quot;&gt;0000-0002-8210-705X&lt;/externalLink&gt;)
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  Data: Routledge. Available from: Taylor &amp; Francis, Ltd. 530 Walnut Street Suite 850, Philadelphia, PA 19106. Tel: 800-354-1420; Tel: 215-625-8900; Fax: 215-207-0050; Web site: http://www.tandf.co.uk/journals
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Pakistan%22&quot;&gt;Pakistan&lt;/searchLink&gt;
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  Data: 10.1080/20473869.2018.1533084
– Name: ISSN
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  Data: 2047-3869
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: Inborn errors of metabolism (IEMs) are rare genetic disorders. Generally, IEMs are untreatable; however, some IEMs causing intellectual disability are potentially treatable if diagnosed earlier. In this study, levels of some clinically important biochemical parameters in intellectually disabled children suspected for IEMs were tested to see their association with intellectual disability, which could be helpful in preliminary screening. Methods: This comparative cross-sectional observational study was carried out from 2014 to 2017. Blood samples from 800 boys and girls (aged 4-24 years) were collected, of which 391 were healthy (IQ &gt;90) and 409 were intellectually disabled (IQ &lt;70) children with unknown cause. Clinically important (Liver and kidney enzymes etc.) biochemical parameters were analyzed in sera samples using commercial kits on semi-automated clinical chemistry analyzer. Results: Serum analysis showed the levels of ALP (p &lt; 0.00001), ASAT (p = 0.001), ALAT (p = 0.016), albumin (p &lt; 0.001), uric acid (p &lt; 0.001), cholesterol (p &lt; 0.001), triglycerides (p &lt; 0.001), and hemoglobin (p = 0.005) were significantly different between healthy and intellectually disabled children. Conclusion: Changes in the liver function test and lipid profile parameters were significantly different in children with intellectual disability; however, it requires further detailed analysis for complete characterization of these diseases.
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  Data: As Provided
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  Data: 2020
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  Data: EJ1255587
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=eric&AN=EJ1255587
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        Value: 10.1080/20473869.2018.1533084
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 190
    Subjects:
      – SubjectFull: Biochemistry
        Type: general
      – SubjectFull: Screening Tests
        Type: general
      – SubjectFull: Foreign Countries
        Type: general
      – SubjectFull: Metabolism
        Type: general
      – SubjectFull: Genetic Disorders
        Type: general
      – SubjectFull: Clinical Diagnosis
        Type: general
      – SubjectFull: Intellectual Disability
        Type: general
      – SubjectFull: Comparative Analysis
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      – SubjectFull: Case Studies
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      – SubjectFull: Diseases
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      – SubjectFull: Profiles
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      – SubjectFull: Preschool Children
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      – SubjectFull: Children
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      – SubjectFull: Young Adults
        Type: general
      – SubjectFull: Adolescents
        Type: general
      – SubjectFull: Pakistan
        Type: general
    Titles:
      – TitleFull: Biochemical Screening of Intellectually Disabled and Healthy Children in Punjab, Pakistan: Differences in Liver Function Test and Lipid Profiles
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            NameFull: Wasim, Muhammad
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            NameFull: Khan, Haq Nawaz
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            NameFull: Ayesha, Hina
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            NameFull: Awan, Fazli Rabbi
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              Y: 2020
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              Value: 66
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            – TitleFull: International Journal of Developmental Disabilities
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