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Genome Sequencing Guide: An Introductory Toolbox to Whole-Genome Analysis Methods

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Title: Genome Sequencing Guide: An Introductory Toolbox to Whole-Genome Analysis Methods
Language: English
Authors: Burian, Alexis N., Zhao, Wufan, Lo, Te-Wen (ORCID 0000-0002-1231-5531), Thurtle-Schmidt, Deborah M. (ORCID 0000-0002-9747-9585)
Source: Biochemistry and Molecular Biology Education. Sep-Oct 2021 49(5):815-825.
Availability: Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
Peer Reviewed: Y
Page Count: 11
Publication Date: 2021
Intended Audience: Teachers
Document Type: Journal Articles
Reports - Descriptive
Guides - Classroom - Teacher
Descriptors: Genetics, Science Instruction, Teaching Methods, Biology, Statistical Analysis, Medicine, Data Analysis, Ethics, Social Problems, Scientific Research, Case Studies, Guides
DOI: 10.1002/bmb.21561
ISSN: 1470-8175
Abstract: To fully appreciate genetics, one must understand the link between genotype (DNA sequence) and phenotype (observable characteristics). Advances in high-throughput genomic sequencing technologies and applications, so-called "-omics," have made genetic sequencing readily available across fields in biology from applications in non-traditional study organisms to precision medicine. Thus, understanding these tools is critical for any biologist, especially those early in their career. This comprehensive review discusses the chronological development of different sequencing methods, the bioinformatics steps to analyzing this data, and social and ethical issues raised by these techniques that must be discussed and evaluated, including anticipatory guides and discussion questions for active engagement in the classroom. Additionally, the Supporting Information includes a case study to apply technical and ethical concepts from the text.
Abstractor: As Provided
Entry Date: 2021
Accession Number: EJ1310247
Database: ERIC
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  Data: <searchLink fieldCode="AR" term="%22Burian%2C+Alexis+N%2E%22">Burian, Alexis N.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Wufan%22">Zhao, Wufan</searchLink><br /><searchLink fieldCode="AR" term="%22Lo%2C+Te-Wen%22">Lo, Te-Wen</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0002-1231-5531">0000-0002-1231-5531</externalLink>)<br /><searchLink fieldCode="AR" term="%22Thurtle-Schmidt%2C+Deborah+M%2E%22">Thurtle-Schmidt, Deborah M.</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0002-9747-9585">0000-0002-9747-9585</externalLink>)
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  Data: Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
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  Data: To fully appreciate genetics, one must understand the link between genotype (DNA sequence) and phenotype (observable characteristics). Advances in high-throughput genomic sequencing technologies and applications, so-called "-omics," have made genetic sequencing readily available across fields in biology from applications in non-traditional study organisms to precision medicine. Thus, understanding these tools is critical for any biologist, especially those early in their career. This comprehensive review discusses the chronological development of different sequencing methods, the bioinformatics steps to analyzing this data, and social and ethical issues raised by these techniques that must be discussed and evaluated, including anticipatory guides and discussion questions for active engagement in the classroom. Additionally, the Supporting Information includes a case study to apply technical and ethical concepts from the text.
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