Prenatal Trace Elements Mixture Is Associated with Learning Deficits on a Behavioral Acquisition Task among Young Children
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| Title: | Prenatal Trace Elements Mixture Is Associated with Learning Deficits on a Behavioral Acquisition Task among Young Children |
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| Language: | English |
| Authors: | Merced-Nieves, Francheska M. (ORCID |
| Source: | New Directions for Child and Adolescent Development. Mar 2022 (181-182):53-66. |
| Availability: | Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us |
| Peer Reviewed: | Y |
| Page Count: | 14 |
| Publication Date: | 2022 |
| Document Type: | Journal Articles Reports - Research |
| Descriptors: | Young Children, Foreign Countries, Learning Problems, Prenatal Influences, Hazardous Materials, Task Analysis, Cognitive Development, Child Development, Child Behavior |
| Geographic Terms: | Mexico (Mexico City) |
| DOI: | 10.1002/cad.20458 |
| ISSN: | 1520-3247 1534-8687 |
| Abstract: | Children are exposed to many trace elements throughout their development. Given their ubiquity and potential to have effects on children's neurodevelopment, these exposures are a public health concern. This study sought to identify trace element mixture-associated deficits in learning behavior using operant testing in a prospective cohort. We included 322 participants aged 6-7 years recruited in Mexico City with complete data on prenatal trace elements measurements (third trimester blood lead and manganese levels, and & urine cadmium and arsenic levels), demographic covariates, and the Incremental Repeated Acquisition (IRA), an associative learning task. Weighted quantile sum (WQS) regression models were used to estimate the joint association of the mixture of all four trace elements and IRA performance. Performance was adversely impacted by the mixture, with different elements relating to different aspects of task performance suggesting that prenatal exposure to trace element mixtures yields a broad dysregulation of learning behavior. |
| Abstractor: | As Provided |
| Entry Date: | 2022 |
| Accession Number: | EJ1348921 |
| Database: | ERIC |
| Abstract: | Children are exposed to many trace elements throughout their development. Given their ubiquity and potential to have effects on children's neurodevelopment, these exposures are a public health concern. This study sought to identify trace element mixture-associated deficits in learning behavior using operant testing in a prospective cohort. We included 322 participants aged 6-7 years recruited in Mexico City with complete data on prenatal trace elements measurements (third trimester blood lead and manganese levels, and & urine cadmium and arsenic levels), demographic covariates, and the Incremental Repeated Acquisition (IRA), an associative learning task. Weighted quantile sum (WQS) regression models were used to estimate the joint association of the mixture of all four trace elements and IRA performance. Performance was adversely impacted by the mixture, with different elements relating to different aspects of task performance suggesting that prenatal exposure to trace element mixtures yields a broad dysregulation of learning behavior. |
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| ISSN: | 1520-3247 1534-8687 |
| DOI: | 10.1002/cad.20458 |
