Fluoxetine, Smoking, and History of Major Depression: A Randomized Controlled Trial
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| Title: | Fluoxetine, Smoking, and History of Major Depression: A Randomized Controlled Trial |
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| Language: | English |
| Authors: | Spring, Bonnie, Doran, Neal, Pagoto, Sherry |
| Source: | Journal of Consulting and Clinical Psychology. Feb 2007 75(1):85-94. |
| Availability: | American Psychological Association. Journals Department, 750 First Street NE, Washington, DC 20002-4242. Tel: 800-374-2721; Tel: 202-336-5510; Fax: 202-336-5502; e-mail: order@apa.org; Web site: http://www.apa.org/publications |
| Peer Reviewed: | Y |
| Page Count: | 10 |
| Publication Date: | 2007 |
| Document Type: | Journal Articles Reports - Research |
| Descriptors: | Depression (Psychology), Smoking, Drug Therapy, Outcomes of Treatment, Health Behavior, Behavior Change, Comparative Analysis, Drug Addiction |
| ISSN: | 0022-006X |
| Abstract: | The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p = 0.02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p = 0.02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence. |
| Abstractor: | Author |
| Entry Date: | 2007 |
| Access URL: | https://content.apa.org/journals/ccp/75/1/85 |
| Accession Number: | EJ754481 |
| Database: | ERIC |
| Abstract: | The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p = 0.02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p = 0.02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence. |
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| ISSN: | 0022-006X |
