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Fluoxetine, Smoking, and History of Major Depression: A Randomized Controlled Trial

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Title: Fluoxetine, Smoking, and History of Major Depression: A Randomized Controlled Trial
Language: English
Authors: Spring, Bonnie, Doran, Neal, Pagoto, Sherry
Source: Journal of Consulting and Clinical Psychology. Feb 2007 75(1):85-94.
Availability: American Psychological Association. Journals Department, 750 First Street NE, Washington, DC 20002-4242. Tel: 800-374-2721; Tel: 202-336-5510; Fax: 202-336-5502; e-mail: order@apa.org; Web site: http://www.apa.org/publications
Peer Reviewed: Y
Page Count: 10
Publication Date: 2007
Document Type: Journal Articles
Reports - Research
Descriptors: Depression (Psychology), Smoking, Drug Therapy, Outcomes of Treatment, Health Behavior, Behavior Change, Comparative Analysis, Drug Addiction
ISSN: 0022-006X
Abstract: The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p = 0.02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p = 0.02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence.
Abstractor: Author
Entry Date: 2007
Access URL: https://content.apa.org/journals/ccp/75/1/85
Accession Number: EJ754481
Database: ERIC
FullText Text:
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  Data: Fluoxetine, Smoking, and History of Major Depression: A Randomized Controlled Trial
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  Data: American Psychological Association. Journals Department, 750 First Street NE, Washington, DC 20002-4242. Tel: 800-374-2721; Tel: 202-336-5510; Fax: 202-336-5502; e-mail: order@apa.org; Web site: http://www.apa.org/publications
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  Data: The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p = 0.02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p = 0.02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence.
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      – SubjectFull: Depression (Psychology)
        Type: general
      – SubjectFull: Smoking
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      – SubjectFull: Drug Therapy
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      – SubjectFull: Outcomes of Treatment
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      – SubjectFull: Health Behavior
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      – SubjectFull: Behavior Change
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      – SubjectFull: Comparative Analysis
        Type: general
      – SubjectFull: Drug Addiction
        Type: general
    Titles:
      – TitleFull: Fluoxetine, Smoking, and History of Major Depression: A Randomized Controlled Trial
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            NameFull: Spring, Bonnie
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            NameFull: Doran, Neal
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            NameFull: Pagoto, Sherry
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