Transient Hippocampal Down-Regulation of Kv1.1 Subunit mRNA during Associative Learning in Rats
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| Title: | Transient Hippocampal Down-Regulation of Kv1.1 Subunit mRNA during Associative Learning in Rats |
|---|---|
| Language: | English |
| Authors: | Kourrich, Said, Manrique, Christine, Salin, Pascal |
| Source: | Learning & Memory. Sep 2005 12(5):511-519. |
| Availability: | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/ |
| Peer Reviewed: | Y |
| Physical Description: | |
| Page Count: | 9 |
| Publication Date: | 2005 |
| Document Type: | Journal Articles Reports - Research |
| Descriptors: | Memory, Associative Learning, Animals, Biochemistry, Brain Hemisphere Functions, Learning Processes, Task Analysis, Correlation, Conditioning |
| DOI: | 10.1101/lm.86305 |
| ISSN: | 1072-0502 |
| Abstract: | Voltage-gated potassium channels (Kv) are critically involved in learning and memory processes. It is not known, however, whether the expression of the Kv1.1 subunit, constituting Kv1 channels, can be specifically regulated in brain areas important for learning and memory processing. Radioactive in situ hybridization was used to evaluate the content of Kv1.1 [alpha]-subunit mRNA in the olfactory bulb, ventral, and dorsal hippocampus at different stages of an odor-discrimination associative task in rats. Naive, conditioned, and pseudoconditioned animals were sacrificed at different times either prior to a two-odor significance learning or after odor discrimination was established. Important decreases of Kv1.1 mRNA levels were transiently observed in the ventral hippocampus before successful learning when compared with the pseudoconditioned group. Moreover, temporal group analysis showed significant labeling alterations in the hippocampus of conditioned and pseudoconditioned groups throughout the training. Finally, Kv1.1 mRNA levels in the hippocampus were positively correlated with odor-reward association learning in rats that were beginning to discriminate between odors. These findings indicate that the Kv1.1 subunit is transiently down-regulated in the early stages of learning and suggest that Kv1 channel expression regulation is critical for the modification of neuronal substrates underlying new information acquisition. (Contains 2 tables and 7 figures.) |
| Abstractor: | Author |
| Number of References: | 54 |
| Entry Date: | 2007 |
| Accession Number: | EJ768115 |
| Database: | ERIC |
| FullText | Text: Availability: 0 |
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| Header | DbId: eric DbLabel: ERIC An: EJ768115 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Transient Hippocampal Down-Regulation of Kv1.1 Subunit mRNA during Associative Learning in Rats – Name: Language Label: Language Group: Lang Data: English – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kourrich%2C+Said%22">Kourrich, Said</searchLink><br /><searchLink fieldCode="AR" term="%22Manrique%2C+Christine%22">Manrique, Christine</searchLink><br /><searchLink fieldCode="AR" term="%22Salin%2C+Pascal%22">Salin, Pascal</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="SO" term="%22Learning+%26+Memory%22"><i>Learning & Memory</i></searchLink>. Sep 2005 12(5):511-519. – Name: Avail Label: Availability Group: Avail Data: Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/ – Name: PeerReviewed Label: Peer Reviewed Group: SrcInfo Data: Y – Name: PhysDesc Label: Physical Description Group: PhysDesc Data: PDF – Name: Pages Label: Page Count Group: Src Data: 9 – Name: DatePubCY Label: Publication Date Group: Date Data: 2005 – Name: TypeDocument Label: Document Type Group: TypDoc Data: Journal Articles<br />Reports - Research – Name: Subject Label: Descriptors Group: Su Data: <searchLink fieldCode="DE" term="%22Memory%22">Memory</searchLink><br /><searchLink fieldCode="DE" term="%22Associative+Learning%22">Associative Learning</searchLink><br /><searchLink fieldCode="DE" term="%22Animals%22">Animals</searchLink><br /><searchLink fieldCode="DE" term="%22Biochemistry%22">Biochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+Hemisphere+Functions%22">Brain Hemisphere Functions</searchLink><br /><searchLink fieldCode="DE" term="%22Learning+Processes%22">Learning Processes</searchLink><br /><searchLink fieldCode="DE" term="%22Task+Analysis%22">Task Analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Correlation%22">Correlation</searchLink><br /><searchLink fieldCode="DE" term="%22Conditioning%22">Conditioning</searchLink> – Name: DOI Label: DOI Group: ID Data: 10.1101/lm.86305 – Name: ISSN Label: ISSN Group: ISSN Data: 1072-0502 – Name: Abstract Label: Abstract Group: Ab Data: Voltage-gated potassium channels (Kv) are critically involved in learning and memory processes. It is not known, however, whether the expression of the Kv1.1 subunit, constituting Kv1 channels, can be specifically regulated in brain areas important for learning and memory processing. Radioactive in situ hybridization was used to evaluate the content of Kv1.1 [alpha]-subunit mRNA in the olfactory bulb, ventral, and dorsal hippocampus at different stages of an odor-discrimination associative task in rats. Naive, conditioned, and pseudoconditioned animals were sacrificed at different times either prior to a two-odor significance learning or after odor discrimination was established. Important decreases of Kv1.1 mRNA levels were transiently observed in the ventral hippocampus before successful learning when compared with the pseudoconditioned group. Moreover, temporal group analysis showed significant labeling alterations in the hippocampus of conditioned and pseudoconditioned groups throughout the training. Finally, Kv1.1 mRNA levels in the hippocampus were positively correlated with odor-reward association learning in rats that were beginning to discriminate between odors. These findings indicate that the Kv1.1 subunit is transiently down-regulated in the early stages of learning and suggest that Kv1 channel expression regulation is critical for the modification of neuronal substrates underlying new information acquisition. (Contains 2 tables and 7 figures.) – Name: AbstractInfo Label: Abstractor Group: Ab Data: Author – Name: Ref Label: Number of References Group: RefInfo Data: 54 – Name: DateEntry Label: Entry Date Group: Date Data: 2007 – Name: AN Label: Accession Number Group: ID Data: EJ768115 |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=eric&AN=EJ768115 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1101/lm.86305 Languages: – Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 511 Subjects: – SubjectFull: Memory Type: general – SubjectFull: Associative Learning Type: general – SubjectFull: Animals Type: general – SubjectFull: Biochemistry Type: general – SubjectFull: Brain Hemisphere Functions Type: general – SubjectFull: Learning Processes Type: general – SubjectFull: Task Analysis Type: general – SubjectFull: Correlation Type: general – SubjectFull: Conditioning Type: general Titles: – TitleFull: Transient Hippocampal Down-Regulation of Kv1.1 Subunit mRNA during Associative Learning in Rats Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kourrich, Said – PersonEntity: Name: NameFull: Manrique, Christine – PersonEntity: Name: NameFull: Salin, Pascal IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Type: published Y: 2005 Identifiers: – Type: issn-print Value: 1072-0502 Numbering: – Type: volume Value: 12 – Type: issue Value: 5 Titles: – TitleFull: Learning & Memory Type: main |
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