Levetiracetam in Absence Epilepsy
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| Title: | Levetiracetam in Absence Epilepsy |
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| Language: | English |
| Authors: | Verrotti, Alberto, Cerminara, Caterina, Domizio, Sergio, Mohn, Angelika, Franzoni, Emilio, Coppola, Giangennaro, Zamponi, Nelia, Parisi, Pasquale, Iannetti, Paola, Curatolo, Paolo |
| Source: | Developmental Medicine & Child Neurology. Nov 2008 50(11):850-853. |
| Availability: | Wiley-Blackwell. 350 Main Street, Malden, MA 02148. Tel: 800-835-6770; Tel: 781-388-8598; Fax: 781-388-8232; e-mail: cs-journals@wiley.com; Web site: http://www.wiley.com/WileyCDA/ |
| Peer Reviewed: | Y |
| Page Count: | 4 |
| Publication Date: | 2008 |
| Document Type: | Journal Articles Reports - Evaluative |
| Descriptors: | Epilepsy, Seizures, Drug Therapy, Children, Adolescents, Patients, Outcomes of Treatment, Foreign Countries |
| Geographic Terms: | Italy |
| DOI: | 10.1111/j.1469-8749.2008.03099.x |
| ISSN: | 0012-1622 |
| Abstract: | The aim of the study was to assess the efficacy, tolerability, and safety of levetiracetam therapy in children and adolescents with absence epilepsy. Twenty-one participants (11 male, 10 female) with typical absence seizures were enrolled in this prospective study from seven centres in Italy. The mean age and age range at time of enrolment into the study were 8 years 9 months (SD 0.9) and 5 years 1 month to 13 years respectively. All patients were carefully evaluated at 6 months from baseline, and 12 patients were also re-evaluated at 12 months after the beginning of therapy with levetiracetam. At the 6-month evaluation, out of 21 patients studied, 11 were seizure free and one showed "decreased" seizures (more than 50% reduction in seizures). A less than 50% reduction in seizures was observed in nine patients. At the 12-month evaluation, 10 patients were completely seizure free and two were seizure free with some anomalies in electroencephalograms. Two patients who had shown no improvement at 6 months had decreased seizures at the second follow-up. Our results suggest that monotherapy with levetiracetam could be effective and well tolerated in patients with childhood absence epilepsy and juvenile absence epilepsy. Prospective, large, long-term double-blind studies are needed to confirm these findings. (Contains 1 table.) |
| Abstractor: | As Provided |
| Number of References: | 34 |
| Entry Date: | 2011 |
| Accession Number: | EJ944891 |
| Database: | ERIC |
| Abstract: | The aim of the study was to assess the efficacy, tolerability, and safety of levetiracetam therapy in children and adolescents with absence epilepsy. Twenty-one participants (11 male, 10 female) with typical absence seizures were enrolled in this prospective study from seven centres in Italy. The mean age and age range at time of enrolment into the study were 8 years 9 months (SD 0.9) and 5 years 1 month to 13 years respectively. All patients were carefully evaluated at 6 months from baseline, and 12 patients were also re-evaluated at 12 months after the beginning of therapy with levetiracetam. At the 6-month evaluation, out of 21 patients studied, 11 were seizure free and one showed "decreased" seizures (more than 50% reduction in seizures). A less than 50% reduction in seizures was observed in nine patients. At the 12-month evaluation, 10 patients were completely seizure free and two were seizure free with some anomalies in electroencephalograms. Two patients who had shown no improvement at 6 months had decreased seizures at the second follow-up. Our results suggest that monotherapy with levetiracetam could be effective and well tolerated in patients with childhood absence epilepsy and juvenile absence epilepsy. Prospective, large, long-term double-blind studies are needed to confirm these findings. (Contains 1 table.) |
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| ISSN: | 0012-1622 |
| DOI: | 10.1111/j.1469-8749.2008.03099.x |
