View in EDS PDF Full Text

Levetiracetam in Absence Epilepsy

Saved in:
Bibliographic Details
Title: Levetiracetam in Absence Epilepsy
Language: English
Authors: Verrotti, Alberto, Cerminara, Caterina, Domizio, Sergio, Mohn, Angelika, Franzoni, Emilio, Coppola, Giangennaro, Zamponi, Nelia, Parisi, Pasquale, Iannetti, Paola, Curatolo, Paolo
Source: Developmental Medicine & Child Neurology. Nov 2008 50(11):850-853.
Availability: Wiley-Blackwell. 350 Main Street, Malden, MA 02148. Tel: 800-835-6770; Tel: 781-388-8598; Fax: 781-388-8232; e-mail: cs-journals@wiley.com; Web site: http://www.wiley.com/WileyCDA/
Peer Reviewed: Y
Page Count: 4
Publication Date: 2008
Document Type: Journal Articles
Reports - Evaluative
Descriptors: Epilepsy, Seizures, Drug Therapy, Children, Adolescents, Patients, Outcomes of Treatment, Foreign Countries
Geographic Terms: Italy
DOI: 10.1111/j.1469-8749.2008.03099.x
ISSN: 0012-1622
Abstract: The aim of the study was to assess the efficacy, tolerability, and safety of levetiracetam therapy in children and adolescents with absence epilepsy. Twenty-one participants (11 male, 10 female) with typical absence seizures were enrolled in this prospective study from seven centres in Italy. The mean age and age range at time of enrolment into the study were 8 years 9 months (SD 0.9) and 5 years 1 month to 13 years respectively. All patients were carefully evaluated at 6 months from baseline, and 12 patients were also re-evaluated at 12 months after the beginning of therapy with levetiracetam. At the 6-month evaluation, out of 21 patients studied, 11 were seizure free and one showed "decreased" seizures (more than 50% reduction in seizures). A less than 50% reduction in seizures was observed in nine patients. At the 12-month evaluation, 10 patients were completely seizure free and two were seizure free with some anomalies in electroencephalograms. Two patients who had shown no improvement at 6 months had decreased seizures at the second follow-up. Our results suggest that monotherapy with levetiracetam could be effective and well tolerated in patients with childhood absence epilepsy and juvenile absence epilepsy. Prospective, large, long-term double-blind studies are needed to confirm these findings. (Contains 1 table.)
Abstractor: As Provided
Number of References: 34
Entry Date: 2011
Accession Number: EJ944891
Database: ERIC
FullText Links:
  – Type: pdflink
    Url: https://content.ebscohost.com/cds/retrieve?content=AQICAHj0k_4E0hTGH8RJwT4gCJyBsGNe_WN95AvKlDbXJGqwxwHmlfDWvY6KwzLG3yavviO-AAAA4jCB3wYJKoZIhvcNAQcGoIHRMIHOAgEAMIHIBgkqhkiG9w0BBwEwHgYJYIZIAWUDBAEuMBEEDIW6QgixRT4AomssIgIBEICBmpZYJUGqR7PL3N8BrcomM20W41CJuGeP0oMJ7uFqWC2gKwb6BZ_70ADsb2zZs2yF8ut7kdc1iGfZz58kC_rvLGQ5Hfygwy8aCaidcmHOcE_FxTwlNek-SLPCl-dT9ZEfDtMXpDB_qBDP6880ZqALNATRNCcnLciDJCty7XCLKlNIiWyOVmD3K5kkIsX-cOpJP2GB2ljj91QMh-0=
Text:
  Availability: 0
Header DbId: eric
DbLabel: ERIC
An: EJ944891
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Levetiracetam in Absence Epilepsy
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Verrotti%2C+Alberto%22">Verrotti, Alberto</searchLink><br /><searchLink fieldCode="AR" term="%22Cerminara%2C+Caterina%22">Cerminara, Caterina</searchLink><br /><searchLink fieldCode="AR" term="%22Domizio%2C+Sergio%22">Domizio, Sergio</searchLink><br /><searchLink fieldCode="AR" term="%22Mohn%2C+Angelika%22">Mohn, Angelika</searchLink><br /><searchLink fieldCode="AR" term="%22Franzoni%2C+Emilio%22">Franzoni, Emilio</searchLink><br /><searchLink fieldCode="AR" term="%22Coppola%2C+Giangennaro%22">Coppola, Giangennaro</searchLink><br /><searchLink fieldCode="AR" term="%22Zamponi%2C+Nelia%22">Zamponi, Nelia</searchLink><br /><searchLink fieldCode="AR" term="%22Parisi%2C+Pasquale%22">Parisi, Pasquale</searchLink><br /><searchLink fieldCode="AR" term="%22Iannetti%2C+Paola%22">Iannetti, Paola</searchLink><br /><searchLink fieldCode="AR" term="%22Curatolo%2C+Paolo%22">Curatolo, Paolo</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="SO" term="%22Developmental+Medicine+%26+Child+Neurology%22"><i>Developmental Medicine & Child Neurology</i></searchLink>. Nov 2008 50(11):850-853.
– Name: Avail
  Label: Availability
  Group: Avail
  Data: Wiley-Blackwell. 350 Main Street, Malden, MA 02148. Tel: 800-835-6770; Tel: 781-388-8598; Fax: 781-388-8232; e-mail: cs-journals@wiley.com; Web site: http://www.wiley.com/WileyCDA/
– Name: PeerReviewed
  Label: Peer Reviewed
  Group: SrcInfo
  Data: Y
– Name: Pages
  Label: Page Count
  Group: Src
  Data: 4
– Name: DatePubCY
  Label: Publication Date
  Group: Date
  Data: 2008
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: Journal Articles<br />Reports - Evaluative
– Name: Subject
  Label: Descriptors
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Seizures%22">Seizures</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+Therapy%22">Drug Therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescents%22">Adolescents</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink><br /><searchLink fieldCode="DE" term="%22Outcomes+of+Treatment%22">Outcomes of Treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Foreign+Countries%22">Foreign Countries</searchLink>
– Name: Subject
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Italy%22">Italy</searchLink>
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1111/j.1469-8749.2008.03099.x
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 0012-1622
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The aim of the study was to assess the efficacy, tolerability, and safety of levetiracetam therapy in children and adolescents with absence epilepsy. Twenty-one participants (11 male, 10 female) with typical absence seizures were enrolled in this prospective study from seven centres in Italy. The mean age and age range at time of enrolment into the study were 8 years 9 months (SD 0.9) and 5 years 1 month to 13 years respectively. All patients were carefully evaluated at 6 months from baseline, and 12 patients were also re-evaluated at 12 months after the beginning of therapy with levetiracetam. At the 6-month evaluation, out of 21 patients studied, 11 were seizure free and one showed "decreased" seizures (more than 50% reduction in seizures). A less than 50% reduction in seizures was observed in nine patients. At the 12-month evaluation, 10 patients were completely seizure free and two were seizure free with some anomalies in electroencephalograms. Two patients who had shown no improvement at 6 months had decreased seizures at the second follow-up. Our results suggest that monotherapy with levetiracetam could be effective and well tolerated in patients with childhood absence epilepsy and juvenile absence epilepsy. Prospective, large, long-term double-blind studies are needed to confirm these findings. (Contains 1 table.)
– Name: AbstractInfo
  Label: Abstractor
  Group: Ab
  Data: As Provided
– Name: Ref
  Label: Number of References
  Group: RefInfo
  Data: 34
– Name: DateEntry
  Label: Entry Date
  Group: Date
  Data: 2011
– Name: AN
  Label: Accession Number
  Group: ID
  Data: EJ944891
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=eric&AN=EJ944891
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/j.1469-8749.2008.03099.x
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 4
        StartPage: 850
    Subjects:
      – SubjectFull: Epilepsy
        Type: general
      – SubjectFull: Seizures
        Type: general
      – SubjectFull: Drug Therapy
        Type: general
      – SubjectFull: Children
        Type: general
      – SubjectFull: Adolescents
        Type: general
      – SubjectFull: Patients
        Type: general
      – SubjectFull: Outcomes of Treatment
        Type: general
      – SubjectFull: Foreign Countries
        Type: general
      – SubjectFull: Italy
        Type: general
    Titles:
      – TitleFull: Levetiracetam in Absence Epilepsy
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Verrotti, Alberto
      – PersonEntity:
          Name:
            NameFull: Cerminara, Caterina
      – PersonEntity:
          Name:
            NameFull: Domizio, Sergio
      – PersonEntity:
          Name:
            NameFull: Mohn, Angelika
      – PersonEntity:
          Name:
            NameFull: Franzoni, Emilio
      – PersonEntity:
          Name:
            NameFull: Coppola, Giangennaro
      – PersonEntity:
          Name:
            NameFull: Zamponi, Nelia
      – PersonEntity:
          Name:
            NameFull: Parisi, Pasquale
      – PersonEntity:
          Name:
            NameFull: Iannetti, Paola
      – PersonEntity:
          Name:
            NameFull: Curatolo, Paolo
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Type: published
              Y: 2008
          Identifiers:
            – Type: issn-print
              Value: 0012-1622
          Numbering:
            – Type: volume
              Value: 50
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: Developmental Medicine & Child Neurology
              Type: main
ResultId 1