Membrana externa de Helicobacter pylori y su papel en la adhesión al epitelio gástrico.

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Bibliographic Details
Title:	Membrana externa de Helicobacter pylori y su papel en la adhesión al epitelio gástrico.
Alternate Title:	Helicobacter pylori Outer Membrane and Adhesion to the Gastric Epithelium.
Authors:	BARRAGÁN VIDAL, CARLOS EDUARDO¹, GUTIÉRREZ-ESCOBAR, ANDRÉS JULIÁN¹, CASTIBLANCO ROBAYO, LIZETH PAOLA²
Source:	Universitas Médica. dec2015, Vol. 56 Issue 1, p44-62. 19p.
Subjects:	HELICOBACTER pylori infections, MEMBRANE proteins, BACTERIAL adhesion, BACTERIAL adhesins, HELICOBACTER pylori, PORINS (Proteins), LIPOPOLYSACCHARIDE structure, PHYSIOLOGY
Abstract (English):	The infection caused by Helicobacter pylori is linked to developing gastritis, peptic ulcer and gastric cancer. Several physiopathological mechanisms have been elucidated about the adherence to the gastric epithelium by this pathogen, being the outer membrane proteins (OMPs) its principal research scope. Thus, interest in this protein family is not only because its role during colonization and development of clinical outcomes but also, the fact that some of them can be considered as a novel therapeutic target. This review describes the principal OMP families detailing its role during epithelial cell's colonization and highlights how studying the OMPs properties could contribute towards the development of strategies to control and eradicate this important infection. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	La infección por Helicobacter pylori se relaciona con gastritis, desarrollo de úlceras y cáncer gástrico. Se han dilucidado varios mecanismos fisiopatológicos respecto al proceso de adherencia de este patógeno a las células epiteliales gástricas, de las cuales las proteínas de membrana (PME) constituyen uno de los principales agentes de estudio. El interés por estas proteínas radica no solo en su papel en el proceso de colonización y consecuente desarrollo del proceso patológico, sino también en que algunas de ellas podrían ser consideradas potenciales blancos terapéuticos. En esta revisión se describen las principales PME y su rol en el proceso de adhesión al epitelio, ya que su estudio y caracterización permitirá proponer alternativas eficientes para el control y erradicación de esta infección, que es una de las principales causas asociadas al cáncer gástrico en Colombia y el mundo. [ABSTRACT FROM AUTHOR]
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Database:	MedicLatina

Description
Abstract:	The infection caused by Helicobacter pylori is linked to developing gastritis, peptic ulcer and gastric cancer. Several physiopathological mechanisms have been elucidated about the adherence to the gastric epithelium by this pathogen, being the outer membrane proteins (OMPs) its principal research scope. Thus, interest in this protein family is not only because its role during colonization and development of clinical outcomes but also, the fact that some of them can be considered as a novel therapeutic target. This review describes the principal OMP families detailing its role during epithelial cell's colonization and highlights how studying the OMPs properties could contribute towards the development of strategies to control and eradicate this important infection. [ABSTRACT FROM AUTHOR]
ISSN:	00419095