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Palonosetrón vs. ondansetrón con metoclopramida para la profilaxis de náusea y vómito postoperatorio.

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Title: Palonosetrón vs. ondansetrón con metoclopramida para la profilaxis de náusea y vómito postoperatorio.
Alternate Title: Palonosetron vs. ondansetron with metoclopramide for prophylactic postoperative nausea and vomiting.
Authors: Espinosa-Galindo, Ana María1 anamariaeg@yahoo.com.mx, Torres-Fabela, José Raymundo1, Ferretti, Ulises Cruz1, Gómez-Aguilera, Josué Israel1, Palacios-Ríos, Dionicio1, Gutiérrez, Óscar Vidal2
Source: Medicina Universitaria. oct-dic2013, Vol. 15 Issue 61, p147-151. 5p.
Subjects: ANTIEMETICS, ONDANSETRON, METOCLOPRAMIDE, POSTOPERATIVE nausea & vomiting, HYSTERECTOMY, EPIDURAL analgesia, THERAPEUTICS
Abstract (English): Objective: To compare the efficacy of palonosetron vs. ondansetron/metoclopramide for postoperative nausea and vomiting induced by epidural morphine in female patients subjected to an hysterectomy. Material and methods: A controlled, longitudinal, prospective, comparative, randomized, double blind clinical trial was carried out in 80 patients (40 per group) programmed for abdominal or vaginal hysterectomy. Nausea and vomiting was investigated at one, two, 12 and 24 hours postoperative, and the level of pain using the visual analogue scale. Results: Nausea was present in 10% of the patients treated with palonosetron at 12 hours and in patients treated with ondansetron/metoclopramide at different intervals with a incidence 2.5%. Vomiting was observed in the palonosetron group in 10% at 12 hours and in 2.5% during recovery in the ondansetron/metoclopramide group. However, no significant difference was observed (p>0.05). Conclusions: The superiority of palonosetron over ondansetron/metoclopramide for prophylaxis of nausea and vomiting secondary to epidural morphine was not found. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Objetivo: Comparar la eficacia antiemética de palonosetrón vs. ondansetrón/metoclopramida para la profilaxis de náusea y vómito postoperatorio inducido por morfina epidural, en mujeres a quienes se les realizó histerectomía. Material y métodos: Ensayo clínico controlado, longitudinal, prospectivo, comparativo, aleatorizado, doble ciego en 80 pacientes, programadas para histerectomía abdominal o vaginal. Se investigó la presencia de náusea y vómito a la una, dos, 12 y 24 del periodo postoperatorio, así como la intensidad del dolor, según escala visual análoga. Resultados: La náusea se presentó en el 10% de las pacientes tratadas con palonosetrón a las 12 horas, y en las pacientes tratadas con ondansetrón/metoclopramida se presentó a la una, dos, 12 horas en un 2.5%. El vómito se observó en el grupo tratado con palonosetrón en el 10% a las 12 horas, y en el 2.5% durante la recuperación en el grupo ondansetrón/metoclopramida, sin observar diferencia estadisticamente significativa (p>0.05). Conclusiones: No se encontró una superioridad de palonosetrón sobre el empleo de ondansetrón/metoclopramida, para la profilaxis de náusea y vómito secundario al uso de morfina epidural. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
Description
Abstract:Objective: To compare the efficacy of palonosetron vs. ondansetron/metoclopramide for postoperative nausea and vomiting induced by epidural morphine in female patients subjected to an hysterectomy. Material and methods: A controlled, longitudinal, prospective, comparative, randomized, double blind clinical trial was carried out in 80 patients (40 per group) programmed for abdominal or vaginal hysterectomy. Nausea and vomiting was investigated at one, two, 12 and 24 hours postoperative, and the level of pain using the visual analogue scale. Results: Nausea was present in 10% of the patients treated with palonosetron at 12 hours and in patients treated with ondansetron/metoclopramide at different intervals with a incidence 2.5%. Vomiting was observed in the palonosetron group in 10% at 12 hours and in 2.5% during recovery in the ondansetron/metoclopramide group. However, no significant difference was observed (p>0.05). Conclusions: The superiority of palonosetron over ondansetron/metoclopramide for prophylaxis of nausea and vomiting secondary to epidural morphine was not found. [ABSTRACT FROM AUTHOR]
ISSN:16655796