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Tipificación del virus del papiloma humano en lesiones del epitelio respiratorio.

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Title: Tipificación del virus del papiloma humano en lesiones del epitelio respiratorio.
Authors: Herrera Martínez, Erika Yolanda1 dra.erikahm@hotmail.com, Aguilar Sánchez, Jorge Amador2, Torres Poveda, Kirvis Janneth3, Madrid Marina, Vicente4
Source: Anales de Otorrinolaringología Mexicana. 2013, Vol. 58 Issue 4, p207-211. 5p.
Abstract (English): BACKGROUND: Respiratory papillomatosis is generally believed to be caused by certain subtypes of the human papillomavirus (HPV), which causes significant morbidity in the respiratory system, block the airway; it's recurrent and tends to become malignant. OBJECTIVE: To identify serotypes of VPH in Hospital Juarez de Mexico. MATERIAL AND METHOD: An observational study that included all patients who underwent resection of upper respiratory tumors identified as papilloma between September 2009 to June 2011. Samples were shipped for analized by PCR. RESULTS: Fifteen samples were obtained by surgical resection, 11 samples of laryngeal lesions and 4 of nasal lesions. Of the 11 patients with laryngeal tumor study, we confirmed the diagnosis of laryngeal papillomatosis in 10, 90.9%, 5 patients positive for HPV 6, 50% and 5 HPV 11 positive patients; 4 patients with nasal inverted papilloma, all patients were men. We found in all of them VPH 6 and only one co-infection VPH 11. CONCLUSION: Serotypes found in this study, HPV 6 and 11, are consistent with the literature. It could be useful to detect those patients whose viral serology is more prone to malignancy, and disease courses depending on the serotype, and knowing the epidemiology of our population could help us in the near future protocols about adjuvant therapies and vaccination. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): ANTECEDENTES: La papilomatosis respiratoria es una enfermedad asociada con el virus del papiloma humano. Tiene una morbilidad potencial ya que envuelve la vía aérea, tiende a la recurrencia y puede malignizarse. OBJETIVO: Tipificar el virus de la mucosa respiratoria en el Hospital Juárez de México. MATERIAL Y MÉTODO: Estudio descriptivo, observacional, prospectivo y transversal, en el que se incluyeron todos los pacientes a los que se realizó resección de lesión en el aparato respiratorio superior identificada como papiloma por histopatología de septiembre de 2009 a junio de 2011. Las muestras se enviaron para su tipificación por PCR y secuenciación de VPH. RESULTADOS: Se obtuvieron 15 muestras: 11 muestras de lesiones laríngeas y 4 de lesiones nasales. De los 11 pacientes con tumor laríngeo en estudio, se confirmó el diagnóstico de papilomatosis laríngea en 10, 5 (50%) pacientes positivos a VPH 6 y 5 pacientes positivos para VPH 11. Los pacientes con papiloma nasal invertido fueron 4, todos varones. Se encontró en todos VPH 6 y sólo en un paciente coinfección con VPH 11. CONCLUSIÓN: Los serotipos virales encontrados en este estudio, el VPH 6 y 11, son congruentes con la bibliografía mundial. Podrían ser de utilidad para detectar a los pacientes que por su serología viral sean más propensos a la malignización, así como el curso de la enfermedad según el serotipo. Conocer la epidemiología de nuestra población podría ayudarnos a hacer protocolos en un futuro cercano acerca de terapias coadyuvantes y vacunación. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
Description
Abstract:BACKGROUND: Respiratory papillomatosis is generally believed to be caused by certain subtypes of the human papillomavirus (HPV), which causes significant morbidity in the respiratory system, block the airway; it's recurrent and tends to become malignant. OBJECTIVE: To identify serotypes of VPH in Hospital Juarez de Mexico. MATERIAL AND METHOD: An observational study that included all patients who underwent resection of upper respiratory tumors identified as papilloma between September 2009 to June 2011. Samples were shipped for analized by PCR. RESULTS: Fifteen samples were obtained by surgical resection, 11 samples of laryngeal lesions and 4 of nasal lesions. Of the 11 patients with laryngeal tumor study, we confirmed the diagnosis of laryngeal papillomatosis in 10, 90.9%, 5 patients positive for HPV 6, 50% and 5 HPV 11 positive patients; 4 patients with nasal inverted papilloma, all patients were men. We found in all of them VPH 6 and only one co-infection VPH 11. CONCLUSION: Serotypes found in this study, HPV 6 and 11, are consistent with the literature. It could be useful to detect those patients whose viral serology is more prone to malignancy, and disease courses depending on the serotype, and knowing the epidemiology of our population could help us in the near future protocols about adjuvant therapies and vaccination. [ABSTRACT FROM AUTHOR]
ISSN:16655672