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Factores de riesgo para la infección por el virus de la hepatitis C en la Costa Caribe colombiana: un estudio de casos y controles.

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Title: Factores de riesgo para la infección por el virus de la hepatitis C en la Costa Caribe colombiana: un estudio de casos y controles.
Alternate Title: Risk factors by hepatitis C virus infection in Colombian Caribbean coast: a case control study.
Authors: de Jesús Yepes, Ismael1,2 ismayep@yahoo.com, Lince, Beatriz3, Caez, Clara4, de Vuono, Giovanni2
Source: Biomédica: Revista del Instituto Nacional de Salud. dic2016, Vol. 36 Issue 4, p1-23. 23p.
Abstract (English): Introduction: An estimated 6.8 - 8.9 million people are infected with hepatitis C virus in Latin America, of which less than 1% comes to receive antiviral treatment. Studies so far in Colombia, have attempted to determine the prevalence of the disease in some risk groups, thus preventing the identification of other factors potentially involved in the spread of infection. Objectives: To identify traditional and non-traditional risk factors for chronic hepatitis C in the Colombian Caribbean coast. Materials and methods: A case-control study (1: 3) matched by health care provider company and age (+/- 10 years) conducted in primary care level. All patients with a positive Elisa were performed confirmatory viral load. A multivariate logistic regression analysis identified independent predictors of infection. Results: Blood transfusion (OR 159.2, 95% CI 35.4 to 715; p <0.001) and history of hospitalization before 1994 (OR 4.7, 95% CI 1.3 to 17.1; p = 0.018) were identified as the only two independent predictors of infection. Conclusion: It is necessary to check the reproducibility of these results and performance cost-effectiveness studies before recommending its use in the design of new screening strategies. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción. Se estima que aproximadamente 6,8-8,9 millones de personas están infectadas por el virus de la hepatitis C en Latinoamérica, de los cuales menos del 1% llega a recibir tratamiento antiviral. Los estudios realizados hasta ahora en Colombia han intentado determinar la prevalencia de la enfermedad en algunos grupos de riesgo, lo que ha impedido la identificación de otros factores potencialmente implicados en el contagio. Objetivos. Identificar factores de riesgo tradicionales y no tradicionales para hepatitis C crónica en la Costa Caribe colombiana. Materiales y métodos. Estudio de casos y controles (1:3) emparejados por empresa promotora de salud, edad (+/- 10 años), realizado en primer nivel de atención de la consulta de hepatología y gastroenterología. Todos los pacientes con Elisa positivo se realizaron una carga viral confirmatoria. Un análisis de regresión logística multivariante identificó los predictores independientes de infección. Resultados. La transfusión sanguínea (OR 159,2; IC 95% 35,4 - 715; p <0,001) y el antecedente de hospitalización antes de 1994 (OR 4,7; IC 95% 1,3 - 17,1; p = 0,018) se identificaron como los dos únicos predictores independientes de infección. Conclusión. Es necesario comprobar la reproducibilidad de estos resultados y realizar estudios de costo-efectividad antes de recomendar su utilización en el diseño de nuevas estrategias de cribado. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
Description
Abstract:Introduction: An estimated 6.8 - 8.9 million people are infected with hepatitis C virus in Latin America, of which less than 1% comes to receive antiviral treatment. Studies so far in Colombia, have attempted to determine the prevalence of the disease in some risk groups, thus preventing the identification of other factors potentially involved in the spread of infection. Objectives: To identify traditional and non-traditional risk factors for chronic hepatitis C in the Colombian Caribbean coast. Materials and methods: A case-control study (1: 3) matched by health care provider company and age (+/- 10 years) conducted in primary care level. All patients with a positive Elisa were performed confirmatory viral load. A multivariate logistic regression analysis identified independent predictors of infection. Results: Blood transfusion (OR 159.2, 95% CI 35.4 to 715; p <0.001) and history of hospitalization before 1994 (OR 4.7, 95% CI 1.3 to 17.1; p = 0.018) were identified as the only two independent predictors of infection. Conclusion: It is necessary to check the reproducibility of these results and performance cost-effectiveness studies before recommending its use in the design of new screening strategies. [ABSTRACT FROM AUTHOR]
ISSN:01204157