Effects of transdermal nitroglicerin patches on inflammation and vascular lesion biomarkers in preeclamptic patients.

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Bibliographic Details
Title:	Effects of transdermal nitroglicerin patches on inflammation and vascular lesion biomarkers in preeclamptic patients.
Alternate Title:	Efectos de los parches de nitroglicerina sobre bio-marcadores de inflamación y lesión vascular en preeclámpticas.
Authors:	Reyna-Villasmil, Eduardo¹ sippenbauch@gmail.com, Mejia-Montilla, Jorly¹, Reyna-Villasmil, Nadia², Torres-Cepeda, Duly¹, Santos-Bolívar, Joel¹, Suárez-Torres, Ismael¹, Wilches-Durán, Sandra³, Diego Hernández, Juan^2,3, Graterol-Rivas, Modesto³, Contreras-Velásquez, Julio³, Cerda, Marco³, Garicano, Carlos³
Source:	Archivos Venezolanos de Farmacología y Terapéutica. 2016, Vol. 35 Issue 2, p42-46. 5p.
Subjects:	PREECLAMPSIA, TRANSDERMAL medication, INFLAMMATION, VASCULAR diseases, MORTALITY, PATIENTS
Abstract (English):	Introduction and Objective: Pre-eclampsia is a multisystem disorder that complicates 3%-8% of pregnancies in Western countries and constitutes a major source of morbidity and mortality worldwide. The aim of this study was to examine the effects of transdermal nitroglycerin patches on biomarkers of inflammation and vascular lesion in pre-eclamptic patients. Materials and methods: a prospective study was done in 40 nulliparous preeclamptic patients over 25 weeks of gestation who attended the Obstetric Emergency at Hospital Central "Dr. Urquinaona", Maracaibo, Venezuela. Interleukin 6 and 10, tumor necrosis factor alpha, interferon gamma, C-reactive protein, selectins (p, E and L) and asymmetric dimethylarginine concentrations were measured before and after nitroglycerin transdermal patches treatment (5 mg/twice a day) for 48 hours. Results: The mean maternal and gestational age was 21.77 Â± 3.07 years and 34.23 Â± 1.85 weeks respectively. A significant reduction was observed in systolic and diastolic blood pressure after treatment (p<0.05). However, no modifications were observed in Interleukin 6, Interleukin 10, tumor necrosis factor alpha, interferon gamma, C-reactive protein, selectins and asymmetric dimethylarginine concentrations. We concluded that treatment with nitroglycerin patches did not produce modifications in serum concentrations of inflammation and vascular lesion biomarkers in preeclamptic patients. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	El objetivo de la investigación fue establecer los efectos de tratamiento con parches de nitroglicerina sobre las concentraciones de los bio-marcadores de inflamación y lesión vascular en preeclámpticas. La muestra fue de preeclámpticas nulíparas con embarazos de más de 25 semanas que acudieron a la emergencia obstétrica del Hospital Central "Dr. Urquinaona", Maracaibo, Venezuela. Se midieron las concentraciones interleucinas 6 y 10, factor de necrosis tumoral alfa, interferón gamma, proteína C reactiva, selectinas (P, E y L) y dimetilarginina asimétrica. El tratamiento fue con parches transdérmicos de nitroglicerina de 5 mg, aplicado en la región torácica anterior o lumbar de las pacientes por un período de 12 horas, por un tiempo total de 48 horas. La edad materna promedio fue de 21,77 Â± 3,07 años y la edad gestacional fue de 34,23 Â± 1,85 semanas. Se observó una disminución significativa en la presión arterial sistólica y diastólica al comparar los valores antes y después del tratamiento (p < 0,05). Sin embargo, no se encontraron modificaciones en las concentraciones plasmáticas de interleucina 6, interleucina 10, factor de necrosis tumoral alfa, interferón gamma, proteína C reactiva, selectinas y dimetilarginina asimétrica luego del uso de los parches de nitroglicerina al compararlo con los valores iniciales (p = ns). Se concluye que el tratamiento con parches de nitroglicerina no produce modificaciones en las concentraciones séricas de bio-marcadores de inflamación y lesión vascular en pre-eclámpticas. [ABSTRACT FROM AUTHOR]
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Database:	MedicLatina

Description
Abstract:	Introduction and Objective: Pre-eclampsia is a multisystem disorder that complicates 3%-8% of pregnancies in Western countries and constitutes a major source of morbidity and mortality worldwide. The aim of this study was to examine the effects of transdermal nitroglycerin patches on biomarkers of inflammation and vascular lesion in pre-eclamptic patients. Materials and methods: a prospective study was done in 40 nulliparous preeclamptic patients over 25 weeks of gestation who attended the Obstetric Emergency at Hospital Central "Dr. Urquinaona", Maracaibo, Venezuela. Interleukin 6 and 10, tumor necrosis factor alpha, interferon gamma, C-reactive protein, selectins (p, E and L) and asymmetric dimethylarginine concentrations were measured before and after nitroglycerin transdermal patches treatment (5 mg/twice a day) for 48 hours. Results: The mean maternal and gestational age was 21.77 Â± 3.07 years and 34.23 Â± 1.85 weeks respectively. A significant reduction was observed in systolic and diastolic blood pressure after treatment (p<0.05). However, no modifications were observed in Interleukin 6, Interleukin 10, tumor necrosis factor alpha, interferon gamma, C-reactive protein, selectins and asymmetric dimethylarginine concentrations. We concluded that treatment with nitroglycerin patches did not produce modifications in serum concentrations of inflammation and vascular lesion biomarkers in preeclamptic patients. [ABSTRACT FROM AUTHOR]
ISSN:	07980264