View in EDS PDF Full Text

Effects of transdermal nitroglicerin patches on inflammation and vascular lesion biomarkers in preeclamptic patients.

Saved in:
Bibliographic Details
Title: Effects of transdermal nitroglicerin patches on inflammation and vascular lesion biomarkers in preeclamptic patients.
Alternate Title: Efectos de los parches de nitroglicerina sobre bio-marcadores de inflamación y lesión vascular en preeclámpticas.
Authors: Reyna-Villasmil, Eduardo1 sippenbauch@gmail.com, Mejia-Montilla, Jorly1, Reyna-Villasmil, Nadia2, Torres-Cepeda, Duly1, Santos-Bolívar, Joel1, Suárez-Torres, Ismael1, Wilches-Durán, Sandra3, Diego Hernández, Juan2,3, Graterol-Rivas, Modesto3, Contreras-Velásquez, Julio3, Cerda, Marco3, Garicano, Carlos3
Source: Archivos Venezolanos de Farmacología y Terapéutica. 2016, Vol. 35 Issue 2, p42-46. 5p.
Subjects: PREECLAMPSIA, TRANSDERMAL medication, INFLAMMATION, VASCULAR diseases, MORTALITY, PATIENTS
Abstract (English): Introduction and Objective: Pre-eclampsia is a multisystem disorder that complicates 3%-8% of pregnancies in Western countries and constitutes a major source of morbidity and mortality worldwide. The aim of this study was to examine the effects of transdermal nitroglycerin patches on biomarkers of inflammation and vascular lesion in pre-eclamptic patients. Materials and methods: a prospective study was done in 40 nulliparous preeclamptic patients over 25 weeks of gestation who attended the Obstetric Emergency at Hospital Central "Dr. Urquinaona", Maracaibo, Venezuela. Interleukin 6 and 10, tumor necrosis factor alpha, interferon gamma, C-reactive protein, selectins (p, E and L) and asymmetric dimethylarginine concentrations were measured before and after nitroglycerin transdermal patches treatment (5 mg/twice a day) for 48 hours. Results: The mean maternal and gestational age was 21.77 ± 3.07 years and 34.23 ± 1.85 weeks respectively. A significant reduction was observed in systolic and diastolic blood pressure after treatment (p<0.05). However, no modifications were observed in Interleukin 6, Interleukin 10, tumor necrosis factor alpha, interferon gamma, C-reactive protein, selectins and asymmetric dimethylarginine concentrations. We concluded that treatment with nitroglycerin patches did not produce modifications in serum concentrations of inflammation and vascular lesion biomarkers in preeclamptic patients. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): El objetivo de la investigación fue establecer los efectos de tratamiento con parches de nitroglicerina sobre las concentraciones de los bio-marcadores de inflamación y lesión vascular en preeclámpticas. La muestra fue de preeclámpticas nulíparas con embarazos de más de 25 semanas que acudieron a la emergencia obstétrica del Hospital Central "Dr. Urquinaona", Maracaibo, Venezuela. Se midieron las concentraciones interleucinas 6 y 10, factor de necrosis tumoral alfa, interferón gamma, proteína C reactiva, selectinas (P, E y L) y dimetilarginina asimétrica. El tratamiento fue con parches transdérmicos de nitroglicerina de 5 mg, aplicado en la región torácica anterior o lumbar de las pacientes por un período de 12 horas, por un tiempo total de 48 horas. La edad materna promedio fue de 21,77 ± 3,07 años y la edad gestacional fue de 34,23 ± 1,85 semanas. Se observó una disminución significativa en la presión arterial sistólica y diastólica al comparar los valores antes y después del tratamiento (p < 0,05). Sin embargo, no se encontraron modificaciones en las concentraciones plasmáticas de interleucina 6, interleucina 10, factor de necrosis tumoral alfa, interferón gamma, proteína C reactiva, selectinas y dimetilarginina asimétrica luego del uso de los parches de nitroglicerina al compararlo con los valores iniciales (p = ns). Se concluye que el tratamiento con parches de nitroglicerina no produce modificaciones en las concentraciones séricas de bio-marcadores de inflamación y lesión vascular en pre-eclámpticas. [ABSTRACT FROM AUTHOR]
Copyright of Archivos Venezolanos de Farmacología y Terapéutica is the property of Archivos Venezolanos de Farmacologia y Terapeutica and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: lth
DbLabel: MedicLatina
An: 122891050
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Effects of transdermal nitroglicerin patches on inflammation and vascular lesion biomarkers in preeclamptic patients.
– Name: TitleAlt
  Label: Alternate Title
  Group: TiAlt
  Data: Efectos de los parches de nitroglicerina sobre bio-marcadores de inflamaci&#243;n y lesi&#243;n vascular en preecl&#225;mpticas.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Reyna-Villasmil%2C+Eduardo%22&quot;&gt;Reyna-Villasmil, Eduardo&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; sippenbauch@gmail.com&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mejia-Montilla%2C+Jorly%22&quot;&gt;Mejia-Montilla, Jorly&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Reyna-Villasmil%2C+Nadia%22&quot;&gt;Reyna-Villasmil, Nadia&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Torres-Cepeda%2C+Duly%22&quot;&gt;Torres-Cepeda, Duly&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Santos-Bol&#237;var%2C+Joel%22&quot;&gt;Santos-Bol&#237;var, Joel&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Su&#225;rez-Torres%2C+Ismael%22&quot;&gt;Su&#225;rez-Torres, Ismael&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wilches-Dur&#225;n%2C+Sandra%22&quot;&gt;Wilches-Dur&#225;n, Sandra&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Diego+Hern&#225;ndez%2C+Juan%22&quot;&gt;Diego Hern&#225;ndez, Juan&lt;/searchLink&gt;&lt;relatesTo&gt;2,3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Graterol-Rivas%2C+Modesto%22&quot;&gt;Graterol-Rivas, Modesto&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Contreras-Vel&#225;squez%2C+Julio%22&quot;&gt;Contreras-Vel&#225;squez, Julio&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cerda%2C+Marco%22&quot;&gt;Cerda, Marco&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Garicano%2C+Carlos%22&quot;&gt;Garicano, Carlos&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Archivos+Venezolanos+de+Farmacolog&#237;a+y+Terap&#233;utica%22&quot;&gt;Archivos Venezolanos de Farmacolog&#237;a y Terap&#233;utica&lt;/searchLink&gt;. 2016, Vol. 35 Issue 2, p42-46. 5p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PREECLAMPSIA%22&quot;&gt;PREECLAMPSIA&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22TRANSDERMAL+medication%22&quot;&gt;TRANSDERMAL medication&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22INFLAMMATION%22&quot;&gt;INFLAMMATION&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22VASCULAR+diseases%22&quot;&gt;VASCULAR diseases&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22MORTALITY%22&quot;&gt;MORTALITY&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PATIENTS%22&quot;&gt;PATIENTS&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Introduction and Objective: Pre-eclampsia is a multisystem disorder that complicates 3%-8% of pregnancies in Western countries and constitutes a major source of morbidity and mortality worldwide. The aim of this study was to examine the effects of transdermal nitroglycerin patches on biomarkers of inflammation and vascular lesion in pre-eclamptic patients. Materials and methods: a prospective study was done in 40 nulliparous preeclamptic patients over 25 weeks of gestation who attended the Obstetric Emergency at Hospital Central &quot;Dr. Urquinaona&quot;, Maracaibo, Venezuela. Interleukin 6 and 10, tumor necrosis factor alpha, interferon gamma, C-reactive protein, selectins (p, E and L) and asymmetric dimethylarginine concentrations were measured before and after nitroglycerin transdermal patches treatment (5 mg/twice a day) for 48 hours. Results: The mean maternal and gestational age was 21.77 &#194;&#177; 3.07 years and 34.23 &#194;&#177; 1.85 weeks respectively. A significant reduction was observed in systolic and diastolic blood pressure after treatment (p&lt;0.05). However, no modifications were observed in Interleukin 6, Interleukin 10, tumor necrosis factor alpha, interferon gamma, C-reactive protein, selectins and asymmetric dimethylarginine concentrations. We concluded that treatment with nitroglycerin patches did not produce modifications in serum concentrations of inflammation and vascular lesion biomarkers in preeclamptic patients. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: El objetivo de la investigaci&#243;n fue establecer los efectos de tratamiento con parches de nitroglicerina sobre las concentraciones de los bio-marcadores de inflamaci&#243;n y lesi&#243;n vascular en preecl&#225;mpticas. La muestra fue de preecl&#225;mpticas nul&#237;paras con embarazos de m&#225;s de 25 semanas que acudieron a la emergencia obst&#233;trica del Hospital Central &quot;Dr. Urquinaona&quot;, Maracaibo, Venezuela. Se midieron las concentraciones interleucinas 6 y 10, factor de necrosis tumoral alfa, interfer&#243;n gamma, prote&#237;na C reactiva, selectinas (P, E y L) y dimetilarginina asim&#233;trica. El tratamiento fue con parches transd&#233;rmicos de nitroglicerina de 5 mg, aplicado en la regi&#243;n tor&#225;cica anterior o lumbar de las pacientes por un per&#237;odo de 12 horas, por un tiempo total de 48 horas. La edad materna promedio fue de 21,77 &#194;&#177; 3,07 a&#241;os y la edad gestacional fue de 34,23 &#194;&#177; 1,85 semanas. Se observ&#243; una disminuci&#243;n significativa en la presi&#243;n arterial sist&#243;lica y diast&#243;lica al comparar los valores antes y despu&#233;s del tratamiento (p &lt; 0,05). Sin embargo, no se encontraron modificaciones en las concentraciones plasm&#225;ticas de interleucina 6, interleucina 10, factor de necrosis tumoral alfa, interfer&#243;n gamma, prote&#237;na C reactiva, selectinas y dimetilarginina asim&#233;trica luego del uso de los parches de nitroglicerina al compararlo con los valores iniciales (p = ns). Se concluye que el tratamiento con parches de nitroglicerina no produce modificaciones en las concentraciones s&#233;ricas de bio-marcadores de inflamaci&#243;n y lesi&#243;n vascular en pre-ecl&#225;mpticas. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Archivos Venezolanos de Farmacolog&#237;a y Terap&#233;utica is the property of Archivos Venezolanos de Farmacologia y Terapeutica and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=122891050
RecordInfo BibRecord:
  BibEntity:
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 42
    Subjects:
      – SubjectFull: PREECLAMPSIA
        Type: general
      – SubjectFull: TRANSDERMAL medication
        Type: general
      – SubjectFull: INFLAMMATION
        Type: general
      – SubjectFull: VASCULAR diseases
        Type: general
      – SubjectFull: MORTALITY
        Type: general
      – SubjectFull: PATIENTS
        Type: general
    Titles:
      – TitleFull: Effects of transdermal nitroglicerin patches on inflammation and vascular lesion biomarkers in preeclamptic patients.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Reyna-Villasmil, Eduardo
      – PersonEntity:
          Name:
            NameFull: Mejia-Montilla, Jorly
      – PersonEntity:
          Name:
            NameFull: Reyna-Villasmil, Nadia
      – PersonEntity:
          Name:
            NameFull: Torres-Cepeda, Duly
      – PersonEntity:
          Name:
            NameFull: Santos-Bolívar, Joel
      – PersonEntity:
          Name:
            NameFull: Suárez-Torres, Ismael
      – PersonEntity:
          Name:
            NameFull: Wilches-Durán, Sandra
      – PersonEntity:
          Name:
            NameFull: Diego Hernández, Juan
      – PersonEntity:
          Name:
            NameFull: Graterol-Rivas, Modesto
      – PersonEntity:
          Name:
            NameFull: Contreras-Velásquez, Julio
      – PersonEntity:
          Name:
            NameFull: Cerda, Marco
      – PersonEntity:
          Name:
            NameFull: Garicano, Carlos
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: 2016
              Type: published
              Y: 2016
          Identifiers:
            – Type: issn-print
              Value: 07980264
          Numbering:
            – Type: volume
              Value: 35
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Archivos Venezolanos de Farmacología y Terapéutica
              Type: main
ResultId 1