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Nuevos enfoques moleculares en la regulación de la adipogénesis. El papel de la Conexina 43.

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Title: Nuevos enfoques moleculares en la regulación de la adipogénesis. El papel de la Conexina 43.
Alternate Title: New molecular approaches in adipogenesis regulation: The Connexin 43 Role.
Authors: Rojas-Gomez, Diana Marcela1, Angarita Davila, Lisse2, Cohen-Massabo, Maria Alejandra1, Giacometto, Marcela1, Rojas, Joselyn3,4, Wilches-Duran, Sandra5, Graterol-Rivas, Modesto4, Cerda, Marco5, Contreras-Velasquez, Julio5, Graterol-Silva, Rosemily5, Torres, Maritza3,6, Ortiz, Rina3,7, Siguencia, Wilson3,8, Gonzalez-Casanova, Jorge Enrique9 jorgoca2@gmail.com
Source: Archivos Venezolanos de Farmacología y Terapéutica. 2016, Vol. 35 Issue 4, p86-91. 6p.
Subjects: ADIPOGENESIS, CONNEXINS, ENERGY consumption, PHYSICAL activity, PATHOLOGICAL physiology
Abstract (English): The global prevalence of obesity has been increased rapidly over the past few years mainly due to changes in the lifestyle of the population with a significant increase in energy consumption and decreased levels of physical activity. As a result, the scientific community is interested in a deeper understanding of the mechanisms that regulate the pathophysiology of obesity. In this context, adipogenesis process is an important target of study to understand the obesity and associated pathologies. Recently has been emerged important evidence that involve gap junction channel protein connexin 43 (Cx43) in the regulation of processes related to adipogenesis, whose role is fundamentally anti-adipogenic. However, new functions of Cx43 in the regulation of adipose tissue function also continued to emerge. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): La prevalencia de la obesidad a nivel mundial se ha incrementado rápidamente durante los últimos años debido principalmente a los cambios en el estilo de vida de la población con un aumento significativo en el consumo de energía y disminución de los niveles de actividad física. Es por esto que la comunidad científica está interesada en comprender de forma más profunda los mecanismos que regulan la fisiopatología de la obesidad. Dentro de los diferentes blancos de estudio se encuentra la adipogénesis, cuyo entendimiento es fundamental para comprender el desarrollo de la obesidad y las patologías asociadas a esta. Recientemente ha surgido importantes evidencias que involucran a la proteína de canales de "Gap Junction" conexina 43 (Cx43) en la regulación de los procesos relacionados con adipogénesis, cuyo papel es básicamente anti-adipogénico, sin embargo, nuevas funciones de Cx43 en la regulación de la formación del tejido adiposo siguen descubriéndose. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
Description
Abstract:The global prevalence of obesity has been increased rapidly over the past few years mainly due to changes in the lifestyle of the population with a significant increase in energy consumption and decreased levels of physical activity. As a result, the scientific community is interested in a deeper understanding of the mechanisms that regulate the pathophysiology of obesity. In this context, adipogenesis process is an important target of study to understand the obesity and associated pathologies. Recently has been emerged important evidence that involve gap junction channel protein connexin 43 (Cx43) in the regulation of processes related to adipogenesis, whose role is fundamentally anti-adipogenic. However, new functions of Cx43 in the regulation of adipose tissue function also continued to emerge. [ABSTRACT FROM AUTHOR]
ISSN:07980264