Niveles séricos de adipocitocinas y resistencia a la insulina en el primer trimestre de gestación en adolescentes y su relación con el peso del recién nacido.

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Title: Niveles séricos de adipocitocinas y resistencia a la insulina en el primer trimestre de gestación en adolescentes y su relación con el peso del recién nacido.
Alternate Title: Serum adipokine levels and insulin resistance in the first trimester of pregnancy in adolescents and their relationship with neonatal weight.
Authors: Noreña, Islendy1,2 (AUTHOR) inorenaa@unal.edu.co, Patricia Pardo, Myriam1 (AUTHOR), Mockus, Ismena2 (AUTHOR)
Source: Biomédica: Revista del Instituto Nacional de Salud. sep2018, Vol. 38 Issue 3, p427-436. 10p. 5 Charts.
Abstract (English): Introduction: The approach to the physiology of pregnancy based on adipokine behavior and the homeostasis-insulin resistance (HOMA-IR) model, along with their relationship to neonatal weight, has been poorly studied in adolescent pregnant women. Objective: To determine possible correlations between adipokines –leptin and adiponectin– and HOMA-IR in pregnant women aged 14 to 17 years, and first-trimester body mass index (BMI) and neonatal weight. Materials and methods: In the weeks 11 to 14 of gestation, the biochemical variables leptin, adiponectin, glycemia and insulin were measured and HOMA-IR was calculated. Maternal and neonatal anthropometric variables were obtained. Statistical analysis was performed with Pearson correlation and the p value. Results: We noticed a positive correlation of serum leptin levels with HOMA-IR in the first trimester of gestation (r=0.5, p≤0.000) and a negative correlation between adiponectin and HOMA-IR (r=-0.4; p=0.017), along with positive correlations between BMI and leptin, insulin and HOMA-IR (r=0.83 and p <0.000, r=0.56 and p≤0.000; r=0.54 and p≤0.000, respectively). In adolescent non-obese mothers with no history of dyslipidemia, there was a positive correlation between HOMA-IR and neonatal weight (r=0.43, p=0.012). Conclusions: Leptin and HOMA-IR showed a positive correlation, while adiponectin and HOMA-IR showed a negative correlation. Leptin and HOMA-IR were positively correlated with BMI. HOMA-IR correlated with the weight of neonates of non-obese adolescents without dyslipidemia. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción. Poco se ha estudiado en adolescentes gestantes la fisiología del embarazo con respecto al comportamiento de las adipocitocinas y según el modelo homeostático HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) para evaluar la resistencia a la insulina y su relación con el peso del recién nacido. Objetivo. Determinar posibles correlaciones entre las adipocitocinas leptina y adiponectina, y el HOMA-IR en adolescentes gestantes de 14 a 17 años, el índice de masa corporal en el primer trimestre de gestación y el peso del recién nacido. Materiales y métodos. En las semanas 11 a 14 de gestación, se midieron las variables bioquímicas de la leptina y la adiponectina, así como de la glucemia y la insulina, y se calculó el puntaje del HOMA-IR. Se obtuvieron los datos sobre las variables antropométricas de las madres y los recién nacidos. En el análisis estadístico se calcularon la correlación de Pearson y el valor de p. Resultados. Se evidenció una correlación positiva entre los niveles séricos de la leptina y el HOMA-IR en el primer trimestre de gestación (r=0,5; p≤0,000) y una negativa entre la adiponectina y el HOMAIR (r=-0,4; p=0,017), además de correlaciones positivas del índice de masa corporal con la leptina, la insulina y el HOMA-IR (r=0,83 y p<0,000; r=0,56 y p=<0.000, y r=0,54 y p≤0,000, respectivamente). En madres adolescentes sin obesidad ni antecedentes de dislipidemia, se registró una correlación positiva entre la evaluación HOMA-IR y el peso neonatal (r=0,43; p=0,012). Conclusiones. La leptina y el HOMA-IR presentaron una correlación positiva, y la adiponectina y el HOMA-IR, una negativa. La leptina y el HOMA-IR se correlacionaron de manera positiva con el IMC. El HOMA-IR se correlacionó con el peso de los recién nacidos de adolescentes sin obesidad ni dislipidemia. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
Description
Abstract:Introduction: The approach to the physiology of pregnancy based on adipokine behavior and the homeostasis-insulin resistance (HOMA-IR) model, along with their relationship to neonatal weight, has been poorly studied in adolescent pregnant women. Objective: To determine possible correlations between adipokines –leptin and adiponectin– and HOMA-IR in pregnant women aged 14 to 17 years, and first-trimester body mass index (BMI) and neonatal weight. Materials and methods: In the weeks 11 to 14 of gestation, the biochemical variables leptin, adiponectin, glycemia and insulin were measured and HOMA-IR was calculated. Maternal and neonatal anthropometric variables were obtained. Statistical analysis was performed with Pearson correlation and the p value. Results: We noticed a positive correlation of serum leptin levels with HOMA-IR in the first trimester of gestation (r=0.5, p≤0.000) and a negative correlation between adiponectin and HOMA-IR (r=-0.4; p=0.017), along with positive correlations between BMI and leptin, insulin and HOMA-IR (r=0.83 and p <0.000, r=0.56 and p≤0.000; r=0.54 and p≤0.000, respectively). In adolescent non-obese mothers with no history of dyslipidemia, there was a positive correlation between HOMA-IR and neonatal weight (r=0.43, p=0.012). Conclusions: Leptin and HOMA-IR showed a positive correlation, while adiponectin and HOMA-IR showed a negative correlation. Leptin and HOMA-IR were positively correlated with BMI. HOMA-IR correlated with the weight of neonates of non-obese adolescents without dyslipidemia. [ABSTRACT FROM AUTHOR]
ISSN:01204157
DOI:10.7705/biomedica.v38i4.4035