Control epigenético en la transición epitelio-mesénquima.
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| Title: | Control epigenético en la transición epitelio-mesénquima. |
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| Alternate Title: | Epigenetic Control of Epithelial-Mesenchymal Transition. |
| Authors: | Bernal Forigua, Camila1 (AUTHOR), Otálora, Beatriz Andrea2 (AUTHOR), González, Daniel Mauricio1 (AUTHOR), Bermúdez, Litzy Gisella1 (AUTHOR), Montoya, Christian Fernando3 (AUTHOR), Valderrama, Andrea3 (AUTHOR), Oñate, Cristina3 (AUTHOR), Niederbacher, Nicolás4 (AUTHOR), Pinzón, María José4 (AUTHOR), Camero, Carlos1 (AUTHOR), García, Francisco Javier4 (AUTHOR), Grajales, Diana5 (AUTHOR), Sánchez Velásquez, Paula3 (AUTHOR), Castillo, Cathalina1 (AUTHOR), Cañas Arboleda, Alejandra6 (AUTHOR), Rojas Moreno, Adriana Patricia7 (AUTHOR) rojas-adriana@javeriana.edu.co |
| Source: | Universitas Médica. ene-mar2020, Vol. 61 Issue 1, p1-22. 22p. |
| Abstract (English): | The mesenchymal epithelial transition (MET) process allows a temporary epithelial cell to acquire a mesenchymal phenotype in response to an internal or external stimulus. This process is characterized by the activation and repression of genes involved in different signaling pathways associated with migration, invasion and apoptosis, among others. In this process epigenetics plays a fundamental role. Epigenetics comprises four mechanisms: DNA methylation, covalent modification of histones, non-coding RNAs (RNACs) and chromatin remodeling complexes, which regulate the expression of a gene without altering its sequence. In this topic review, the authors describe the main epigenetic mechanisms involved in the regulation of the expression of genes that are activated and repressed throughout the TEM process. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | El proceso de transición epitelio-mesénquima (TEM) permite que una célula epitelial, de manera temporal, adquiera un fenotipo mesenquimal como respuesta a un estímulo interno o externo. Este proceso se caracteriza por la activación y represión de genes involucrados en diferentes vías de señalización asociadas con migración, invasión, apoptosis, entre otros. En este proceso, la epigenética cumple un papel fundamental, pues comprende cuatro mecanismos: metilación de ADN, modificación covalente de histonas, ARN no codificantes (ARNnc) y complejos remodeladores de la cromatina, que regulan la expresión de un gen sin alterar su secuencia. En esta revisión de tema los autores describen los principales mecanismos epigenéticos involucrados en la regulación de la expresión de genes que se activan y reprimen a lo largo del proceso TEM. [ABSTRACT FROM AUTHOR] |
| Copyright of Universitas Médica is the property of Pontificia Universidad Javeriana and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Abstract: | The mesenchymal epithelial transition (MET) process allows a temporary epithelial cell to acquire a mesenchymal phenotype in response to an internal or external stimulus. This process is characterized by the activation and repression of genes involved in different signaling pathways associated with migration, invasion and apoptosis, among others. In this process epigenetics plays a fundamental role. Epigenetics comprises four mechanisms: DNA methylation, covalent modification of histones, non-coding RNAs (RNACs) and chromatin remodeling complexes, which regulate the expression of a gene without altering its sequence. In this topic review, the authors describe the main epigenetic mechanisms involved in the regulation of the expression of genes that are activated and repressed throughout the TEM process. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00419095 |
| DOI: | 10.11144/Javeriana.umed61-1.epig |
