Bibliographic Details
| Title: |
Prescripción de antibióticos en pacientes hospitalizados con COVID-19 en un hospital privado de Caracas: Estudio retrospectivo. |
| Alternate Title: |
Antibiotic prescription in hospitalized patients with COVID-19 in a private hospital in Caracas: Retrospective study. |
| Authors: |
Silva, Isabel-Carlota1 catirasilva@gmail.com, Guzmán, Manuel1,2, de Oca, María Montes1,2, Bacci, Santiago1, de Abreu, Fátima1, Villarroel, Héctor1, Stulin, Irene1, Blanco, Gabriela1, Sánchez, Laura1, Quevedo, Jennireth1, Arvelo, María Cristina1,2, Valera, Nathalia1, Papa, Irene1, Carlos Catari, Juan1, Luis Lopez, José1, Moran, Brigitte1, Cárdenas, Claudio1, Santucci, Saverio1, Luis Viloria, José1, García, Eleonora1 |
| Source: |
Archivos Venezolanos de Farmacología y Terapéutica. 2021, Vol. 40 Issue 4, p424-431. 8p. |
| Subjects: |
COVID-19, HOSPITAL patients, BACTERIAL cultures, PATHOGENIC bacteria, MIXED infections, INTENSIVE care units, HOSPITALS |
| Abstract (English): |
Background: There is little information on the prevalence of bacterial coinfection and use of antibiotics in hospitalized COVID-19 patients. The present study assesses the frequency of in-hospital antibiotic prescription, the bacterial cultures implementation and the clinical characteristics of patients with COVID-19 according to the use of antibiotics. Methods: Retrospective, observational study of hospitalized patients with COVID-19. The ISARIC-WHO form was used for data collection. Results: 145 patients were included, 95 men and 50 women, with a mean age 63.8±16.0 years. 79/145 (54.5%) patients received antibiotics, 52/145 (35%) had samples for culture and 49/145 (33.8%) were blood cultures. Pathogenic bacteria were isolated only in 7% of the patients. The patients with antibiotics had worse oxygenation, chest tomography and inflammatory markers, more admission to ICU, deaths, and prolonged hospital stay. Conclusion: Our results do not support the initial widespread use of antibiotics in hospitalized COVID-19 patients without knowing the pathogen and its susceptibility. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
Antecedentes: Existe escasa información sobre la prevalencia de la coinfección bacteriana, y uso de antibióticos en pacientes hospitalizados por COVID-19. Este estudio evalúa la frecuencia de prescripción antibióticos intrahospitalario, de cultivos bacterianos y curso clínicos de los pacientes con COVID-19 según uso de antibióticos. Métodos: Estudio retrospectivo, observacional de pacientes hospitalizados con COVID-19. Se uso el formulario de ISARIC-OMS para recopilar datos. Resultados: Se incluyeron 145 pacientes, 95 hombres y 50 mujeres, con edad promedio 63.8±16.0 años. 79/145 (54.5%) pacientes recibieron antibióticos, 52/145 (35%) tuvieron muestras para cultivo y 49/145 (33.8%) fueron hemocultivo. Se aislaron bacterias patógenas en 7% de los pacientes. Los pacientes con antibiótico tenían mayor alteración de oxigenación, tomografía de tórax y marcadores inflamatorios, más ingreso a UCI, fallecimientos, y estancia hospitalaria prolongada. Conclusión: Los resultados no respaldan el uso generalizado inicial de antibióticos en pacientes hospitalizados con COVID-19 sin aislamiento de microrganismos patógenos. [ABSTRACT FROM AUTHOR] |
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| Database: |
MedicLatina |
