Foreign accent syndrome in Multiple Sclerosis, review and case presentation.

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Title:	Foreign accent syndrome in Multiple Sclerosis, review and case presentation.
Alternate Title:	Síndrome acento extranjero en Esclerosis Múltiple, revisión y presentación de un caso.
Authors:	Barriga-Maldonado, Vanessa¹, Posadas-Pinto, Diego Rubén¹, Cruz-Guillermo, Miriam², López-Hernández, Diana Citlalli², Treviño-Frenk, Irene^1,2,3
Source:	Archivos de Neurociencias. Jul-Sep2021, Vol. 26 Issue 3, p40-48. 9p.
Subjects:	MULTIPLE sclerosis, PHYSIOLOGICAL aspects of speech, COGNITION, FOREIGN accent syndrome
Abstract (English):	Introduction. Foreign Accent Syndrome (FAS) is a rare entity. Patients develop changes in rhythm and tone of speech (prosody), perceived as a different accent than their native language. There are three types of FAS: neurogenic, psychogenic and mixed. FAS is rare in ms, and even more so as a first manifestation. Objective. Review of FAS, types, pathophysiology, presentation in ms and evolution. Summary. Cortical lesions in ms are correlated with cognitive impairment, motor disability, psychiatric symptoms, language 3 disorders, speech impairment, and seizures. Most of the published cases of fas have suffered injury in the dominant hemisphere, in the prerrolandic cortex and adjacent areas, frontal motor association areas, in the putamen, basal ganglia, and theposterior fossa (protuberance, cerebellum). Different etiologieshave been reported, vascular being the most frequent. We present the case of a 44-year-old woman who first manifestation was fas, previously interpreted as a brain ischemia and finally diagnosed as multiple sclerosis. This case had partial improvement of the symptoms after phonoaudiologic rehabilitation. Conclusions. FAS is rarely observed as an initial presentation of MS debut, as cortical symptoms are atypical relapses. An inflammatory demyelinating cause should be considered in young patients lacking vascular risk factors, and must be supported by complementary neuroimaging studies. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	Introducción. El Síndrome de Acento Extranjero (SAE) una entidad rara, los pacientes desarrollan cambios en el ritmo y tono del habla (prosodia), percibidos como un acento diferente al de su lengua natal. Existen tres tipos de sae: neurogénico, psicogénico y mixto. El SAE es infrecuente en em, y aún más como primera manifestación. Objetivo. Revisión del sae, tipos, fisiopatología y presentación en EM y evolución. Desarrollo. Las lesiones corticales en EM se correlacionan con deterioro cognitivo, discapacidad motora, síntomas psiquiátricos, alteraciones del lenguaje y crisis epilépticas. La mayoría de los casos publicados de SAE han sufrido lesión en el hemisferio dominante, en corteza prerrolándica y áreas adyacentes, áreas motoras frontales de asociación, en putamen, ganglios basales, fosa posterior (protuberancia, cerebelo), por diferentes 2 etiologías siendo la más frecuente la vascular. Presentamos el caso clínico de una mujer de 44 años que presenta como primera manifestación sae interpretado inicialmente como infarto cerebral en quien finalmente se concluyó el diagnóstico de EM. Ha tenido mejoría parcial de los síntomas con la rehabilitación fonoaudiológica. Conclusiones. SAE es infrecuente como primer síntoma de em. Debe considerarse la etiología desmielinizante en pacientes jóvenes, con escasos o sin factores de riesgo vascular y apoyarse en estudios complementarios de neuroimágen para su diagnóstico. [ABSTRACT FROM AUTHOR]
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Database:	MedicLatina

Description
Abstract:	Introduction. Foreign Accent Syndrome (FAS) is a rare entity. Patients develop changes in rhythm and tone of speech (prosody), perceived as a different accent than their native language. There are three types of FAS: neurogenic, psychogenic and mixed. FAS is rare in ms, and even more so as a first manifestation. Objective. Review of FAS, types, pathophysiology, presentation in ms and evolution. Summary. Cortical lesions in ms are correlated with cognitive impairment, motor disability, psychiatric symptoms, language 3 disorders, speech impairment, and seizures. Most of the published cases of fas have suffered injury in the dominant hemisphere, in the prerrolandic cortex and adjacent areas, frontal motor association areas, in the putamen, basal ganglia, and theposterior fossa (protuberance, cerebellum). Different etiologieshave been reported, vascular being the most frequent. We present the case of a 44-year-old woman who first manifestation was fas, previously interpreted as a brain ischemia and finally diagnosed as multiple sclerosis. This case had partial improvement of the symptoms after phonoaudiologic rehabilitation. Conclusions. FAS is rarely observed as an initial presentation of MS debut, as cortical symptoms are atypical relapses. An inflammatory demyelinating cause should be considered in young patients lacking vascular risk factors, and must be supported by complementary neuroimaging studies. [ABSTRACT FROM AUTHOR]
ISSN:	10285938
DOI:	10.31157/archneurosciencesmex.v26i3.225