Bibliographic Details
| Title: |
β-LACTAMASAS DE ESPECTRO EXTENDIDO Y FACTORES DE VIRULENCIA EN Escherichia coli UROPATÓGENAS EN ASILOS DE ANCIANOS EN LIMA, PERÚ. |
| Alternate Title: |
EXTENDED-SPECTRUM β-LACTAMASES AND VIRULENCE FACTORS IN UROPATHOGENIC Escherichia coli IN NURSING HOMES IN LIMA, PERU. |
| Authors: |
Gonzales-Rodriguez, Arturo Octavio1 arturo.gonzales@udep.edu.pe, Infante Varillas, Stefany Fiorella1, Reyes-Farias, Carlos Ignacio1, Ladines Fajardo, Cesar Enrique1, Gonzales Escalante, Edgar2 |
| Source: |
Revista Peruana de Medicina Experimental y Salud Pública. 2022, Vol. 39 Issue 1, p98-103. 6p. |
| Abstract (English): |
Nursing homes are institutions with high prevalence of urinary tract infections caused by ESBL-producing E. coli with several virulence factors. The aim of this study was to determine the frequency of the blaCTX-M gene and eight virulence genes in 35 ESBL-producing uropathogenic E. coli from six nursing homes in Peru during 2018. Of the E. coli samples, 57.1% (20/35) were carriers of the blaCTX-M gene. Furthermore, we obtained frequencies of 46% (15/35) and 37% (13/35) for hly-alpha and cnf-1, respectively; we also found high presence of the iucC (63%, 22/35), aer (94%, 33/35) and chuA genes (94%, 33/34) as well as a frequency of 46% (16/35) and 91% (32/34) for the pap GII and nanA genes, respectively. The blaCTX-M gene is predominant and a high frequency of exotoxins gives it a competitive advantage for spreading into the bloodstream. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
Los asilos de ancianos son instituciones con una alta prevalencia de infecciones del tracto urinario ocasionado por Escherichia coli productoras de ß-lactamasas de espectro extendido (BLEE), con diversos factores de virulencia. El objetivo del estudio fue determinar la frecuencia del gen blaCTX-M y de ocho genes de virulencia en 35 E. coli uropatógenas productoras de BLEE provenientes de seis asilos en Perú, durante el 2018. El 57,1% (20/35) de las E. coli fueron portadores del gen blaCTX-M. Además, se obtuvo una frecuencia del 46% (15/35) y 37% (13/35) de hly-alfa y cnf-1, respectivamente; elevada presencia de los genes iucC (63%, 22/35), aer (94%, 33/35) y chuA (94%, 33/34) y una frecuencia del 46% (16/35) y del 91% (32/34) de los genes pap GII y nanA, respectivamente. Existe predominancia en la distribución del gen blaCTX-M, además de una alta frecuencia de exotoxinas que le confieren una ventaja competitiva para diseminarse hacia el torrente sanguíneo. [ABSTRACT FROM AUTHOR] |
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| Database: |
MedicLatina |
