Bibliographic Details
| Title: |
Silenciamiento génico en insectos plaga que afectan la industria agrícola usando ARN de interferencia. |
| Alternate Title: |
Gene silencing in pest insects that affect the agricultural industry using interference RNA. |
| Authors: |
Ossa Toro, Lizeth S.1, Padilla Jarava, Dina A.1, Sánchez Leal, Ligia C.2, Fuentes Quintero, Luz Stella3 lconsuelosanchez@unicolmayor.edu.co |
| Source: |
NOVA: Publicación Científica en Ciencias Biomédicas. ene-jun2022, Vol. 20 Issue 38, p159-176. 18p. |
| Subjects: |
SMALL interfering RNA, RNA interference, DOUBLE-stranded RNA, SMALL molecules, MESSENGER RNA |
| Abstract (English): |
Pest insects are species of living organisms that are constantly found in high populations, causing economic crops damage. Generally, it tends to be specific species, usually only one or two, which can cause great economic damage in the agricultural sector. In the last 3 decades, the concept of a biological process has been developed, widely detected in eukaryotes, by which genes can be silenced, from double-stranded RNA (dsRNA). This machinery has been investigated to understand its operation and to look for potential applications that it could have in the field of biotechnology. In several studies it was found that gene silencing is due to cytoplasmic intracellular enzymatic interactions with small RNA molecules (siRNA), which act on intracellular messenger RNA (mRNA), preventing it from translating a protein. Through this mechanism, the aim is to silence specific genes in pest insects, which are essential for the insect to live and thus prevent the proliferation of the pest. This article compiles the studies carried out on RNA interference, referring to the genetic mechanism of insects, as an alternative for its control. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
Los insectos plaga, son especies de organismos vivos que en forma constante se encuentran en poblaciones altas, ocasionando daños económicos en los cultivos. Generalmente, suele tratarse de especies puntuales, por lo general, sólo una o dos, que pueden causar gran afectación económica en el sector de la agricultura. En las últimas 3 décadas se ha venido desarrollando el concepto de un proceso biológico, detectado en eucariotas ampliamente, mediante el que se pueden silenciar genes, a partir de ARN de doble cadena (ARNdc). Esta maquinaria se ha investigado para conocer su funcionamiento y buscar potenciales aplicaciones que podrían tener en el campo de la biotecnología. En varios estudios se encontró que el silenciamiento de genes se debe a las interacciones enzimáticas intracelulares citoplasmáticas con moléculas de ARN pequeñas (ARNsi), que actúan sobre el ARN mensajero (ARNm) intracelular, impidiendo que este se traduzca a proteína. Mediante este mecanismo se busca silenciar genes específicos en insectos plaga, que sean esenciales para que el insecto pueda vivir y de esa manera evitar la proliferación de la plaga. Este artículo recopila los estudios realizados acerca del ARN de interferencia, referidos al mecanismo genético de los insectos, como alternativa para su control. [ABSTRACT FROM AUTHOR] |
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| Database: |
MedicLatina |
