Anemia hemolítica desencadenada por consumo de habas en un paciente con déficit de glucosa 6 fosfato deshidrogenasa: presentación de caso en pediatría.
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| Title: | Anemia hemolítica desencadenada por consumo de habas en un paciente con déficit de glucosa 6 fosfato deshidrogenasa: presentación de caso en pediatría. |
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| Alternate Title: | Hemolytic anemia triggered by the consumption of faba beans in a patient with glucose-6-phosphate dehydrogenase deficiency: a pediatric case report. |
| Authors: | Serrano S., María Carolina1 (AUTHOR) mariac_serrano@javeriana.edu.co, Franco C., Holman Leonel2 (AUTHOR), Pulido B., Adriana Marcela3 (AUTHOR), Gómez L., Erika Johana4 (AUTHOR), Saldaña F., Sebastián4 (AUTHOR) |
| Source: | Universitas Médica. oct-dic2022, Vol. 63 Issue 4, p1-7. 7p. |
| Abstract (English): | Glucose 6 phosphate dehydrogenase deficiency (G6PD) is the most common metabolic disorder of red blood cells, being hemolytic anemia its most frequent presentation which can be triggered by infectious processes, medications or the ingestion of fava beans; the latter called Favism. Objective: To describe the clinical presentation of G6PD deficiency in a child after consumption of fava beans. Clinical case: 3 year old male, who presents with generalized jaundice associated with choluria, consumption of fava beans prior to the onset of symptoms, favism is suspected. Moderate anemia, indirect bilirubin increase, elevation of lactate, peripheral blood smears with spherocytes, and polychromatophilia were documented. Management with folic acid was initiated. A measurement of G6PD enzyme was performed and a moderate (class III) deficiency was confirmed. Conclusion: G6PD deficiency is a diagnostic challenge. With proper management and prevention, cases with severe hemolysis can be avoided. It is important to introduce G6PD analysis in neonatal screening in order to achieve a decrease in infant morbidity and mortality. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | El déficit de glucosa 6 fosfato deshidrogenasa (G6PD) es el trastorno metabólico más frecuente de los glóbulos rojos, y su presentación más común es la anemia hemolítica, que puede desencadenarse por procesos infecciosos, medicamentos o la ingesta de habas; esta última denominada favismo. Objetivo: Describir la presentación clínica del déficit de G6PD en un paciente de 3 años posterior al consumo de habas. Caso clínico: Un niño de 3 años de edad, quien presentó ictericia generalizada asociada con coliuria; consumo de habas previo al inicio de síntomas, y se sospechó favismo. Se documentó anemia moderada, hiperbilirrubinemia indirecta, elevación de lactato deshidrogenasa y frotis de sangre periférica con esferocitos y policromatofilia. Se consideró hemólisis aguda y se inició el manejo con ácido fólico. Se medió la enzima G6PD y se observó una deficiencia moderada (clase III). Conclusión: La deficiencia de G6PD es un reto diagnóstico. Con un adecuado manejo y prevención se pueden evitar casos con hemólisis severa. Es importante introducir en el tamizaje neonatal el análisis de G6PD para así lograr una disminución de morbimortalidad infantil. [ABSTRACT FROM AUTHOR] |
| Copyright of Universitas Médica is the property of Pontificia Universidad Javeriana and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Abstract: | Glucose 6 phosphate dehydrogenase deficiency (G6PD) is the most common metabolic disorder of red blood cells, being hemolytic anemia its most frequent presentation which can be triggered by infectious processes, medications or the ingestion of fava beans; the latter called Favism. Objective: To describe the clinical presentation of G6PD deficiency in a child after consumption of fava beans. Clinical case: 3 year old male, who presents with generalized jaundice associated with choluria, consumption of fava beans prior to the onset of symptoms, favism is suspected. Moderate anemia, indirect bilirubin increase, elevation of lactate, peripheral blood smears with spherocytes, and polychromatophilia were documented. Management with folic acid was initiated. A measurement of G6PD enzyme was performed and a moderate (class III) deficiency was confirmed. Conclusion: G6PD deficiency is a diagnostic challenge. With proper management and prevention, cases with severe hemolysis can be avoided. It is important to introduce G6PD analysis in neonatal screening in order to achieve a decrease in infant morbidity and mortality. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00419095 |
| DOI: | 10.11144/Javeriana.umed63-4.ahvf |
