Bibliographic Details
| Title: |
Coagulación en la práctica médica (Obstetricia crítica). |
| Alternate Title: |
Coagulation in medical practice (critical Obstetrics). |
| Authors: |
Briones Garduño, Jesús Carlos1, Villa Guerrero, Miguel2, Orozco Zúñiga, Benjamín3, Cérbulo Vázquez, Arturo4, Borges Ibáñez, Manuel5, Amaya Pérez, Victoria6, Reyes Mendozav, Luis Emilio7, De Anda Aguilar, Leticia8, Briones Vega, Carlos Gabriel9 |
| Source: |
Revista CONAMED. abr-jun2024, Vol. 29 Issue 2, p146-154. 9p. |
| Abstract (English): |
In clinical practice, physicians must learn to question and explore patients, and we also need to understand and interpret the various laboratory and cabinet tests to integrate diagnoses to propose a therapy, especially in patients with coagulationfibrinolysis disorders, since there is no single laboratory test that comprehensively assesses the mechanism of coagulation and fibrinolysis. Coagulation consists of a series of proteolytic reactions, where each protease cleaves and activates in series the subsequent protease in the cells and the degradation of fibrin called fibrinolysis, we have laboratory tests that study coagulation in parts: prothrombin times or normalized reference index (INR), activated partial thromboplastin time (aPTT), thrombin time (TT), fibrinogen quantification, platelet count, and quantitative determination of D-dimer. We currently have new technologies such as thromboelastometry and rotational thromboelastography (ROTEM) that allow us to comprehensively determine coagulation and fibrinolysis. New therapeutic strategies with the use of tranexamic acid, fibrinogen concentrate and prothrombin complex concentrates, factor rFVIIa (recombinant factor VII) requires concomitant administration of fibrinogen and platelets. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
En la práctica clínica los médicos debemos aprender a interrogar y a explorar pacientes, y también necesitamos comprender e interpretar, los diversos exámenes de laboratorio y gabinete para integrar diagnósticos y con ello proponer una terapéutica, sobre todo en pacientes, con trastornos en coagulación-fibrinolisis, ya que no existe ningún examen de laboratorio único, que valore en forma integral el mecanismo de coagulación y fibrinolisis. La coagulación consiste en una serie de reacciones proteolíticas, donde cada proteasa escinde y activa en serie la proteasa subsiguiente en las células y la degradación de la fibrina denominada fibrinolisis, contamos con pruebas de laboratorio que estudian la coagulación por partes: tiempos de protrombina o índice normalizado de referencia (INR), tiempo parcial de tromboplastina activado (TTPa), tiempo de trombina (TT), cuantificación de fibrinógeno, cuenta de plaquetas y determinación cuantitativa de dímero D. Actualmente disponemos de nuevas tecnologías como la tromboelastometría y la tromboelastografía rotacional (ROTEM) que nos permite determinar en forma integral coagulación y fibrinolisis. Nuevas estrategias terapéuticas con el uso de ácido tranexámico, concentrado de fibrinógenos y concentrados de complejo de protrombina, el factor rFVIIa (factor VII recombinante) requiere administración concomitante de fibrinógeno y plaquetas. [ABSTRACT FROM AUTHOR] |
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| Database: |
MedicLatina |
