PERIODONTITIS APICAL Y SUS EFECTOS SOBRE EL TEJIDO RENAL EN RATAS.

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Bibliographic Details
Title:	PERIODONTITIS APICAL Y SUS EFECTOS SOBRE EL TEJIDO RENAL EN RATAS.
Alternate Title:	APICAL PERIODONTITIS AND ITS EFFECTS ON RENAL TISSUE IN RATS.
Authors:	Mireya Jara, Cynthia¹, Raquel Ramírez, Roccio², Susana Barreto, Regina², García-Salinas, Héctor², Gabriel Adorno, Carlos¹ cgadorno@founa.edu.py, Fretes, Vicente¹, Paola Amarilla, Shyrley³, Díaz-Reissner, Clarisse¹
Source:	Revista Peruana de Medicina Experimental y Salud Pública. 2024, Vol. 41 Issue 4, p385-391. 7p.
Subjects:	LABORATORY rats, PERIAPICAL periodontitis, BLOOD pressure, PLETHYSMOGRAPHY, CHRONIC kidney failure
Abstract (English):	Objetives. To evaluate the effect of apical periodontitis (AP) induced in Wistar rats on histologically examined renal tissue. Materials and methods. Fourteen 12-week-old male Wistar rats weighing an average of 250 grams were used. AP was induced with pulp exposure of the upper and lower first molars using a #1011 HL spherical bur in high rotation. The lesions were left exposed to the oral environment for a period of 7 weeks. Blood pressure was measured by the tail-cuff plethysmography method from the fourth week. The kidney was dissected for histological analysis (H&E). Mann-Whitney and Student's t-test were used for non-parametric and parametric data, respectively, with a significance level of 5%. Results. A statistically significant increase in both Bowman's space area and renal corpuscle area was found in the AP group (p<0.05). The AP group had a higher percentage of renal tissue with inflammatory infiltrate, but without significant difference. Blood pressure did change during the experimental period and no difference was identified between the groups. Conclusions. Induction of AP in Wistar rats resulted in significant changes of certain renal histological parameters, suggesting a possible interaction between AP and renal tissue that requires further research. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	Objetivos. Evaluar el efecto de la periodontitis apical (PA) inducida en ratas Wistar sobre el tejido renal examinado histológicamente. Materiales y métodos. Fueron utilizadas 14 ratas Wistar macho, de 12 semanas y 250 gramos promedio. La PA fue inducida con la exposición pulpar de los primeros molares superiores e inferiores utilizando una fresa esférica #1011 HL en alta rotación. Las lesiones se dejaron expuestas al medio bucal por un periodo de 7 semanas. La presión arterial fue medida mediante el método de pletismografía del manguito de la cola a partir de la cuarta semana. Fue realizada la disección del riñón para análisis histológico (H&E). Fue utilizada la prueba de Mann-Whitney y t de Student para datos no paramétricos y paramétricos, respectivamente, con un nivel de significancia del 5%. Resultados. Se observó un aumento estadísticamente significativo tanto en el área del espacio de Bowman como en el área del corpúsculo renal en el grupo PA (p<0,05). El grupo con PA presentó mayor porcentaje de tejido renal con infiltrado inflamatorio, pero sin diferencia significativa. La presión arterial no sufrió modificaciones durante el periodo experimental y no fue identificada diferencia entre los grupos. Conclusiones. La inducción de PA en ratas Wistar resultó en modificaciones significativas de ciertos parámetros histológicos renales, sugiriendo una posible interacción entre la PA y el tejido renal que requiere de investigaciones adicionales. [ABSTRACT FROM AUTHOR]
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Database:	MedicLatina

Description
Abstract:	Objetives. To evaluate the effect of apical periodontitis (AP) induced in Wistar rats on histologically examined renal tissue. Materials and methods. Fourteen 12-week-old male Wistar rats weighing an average of 250 grams were used. AP was induced with pulp exposure of the upper and lower first molars using a #1011 HL spherical bur in high rotation. The lesions were left exposed to the oral environment for a period of 7 weeks. Blood pressure was measured by the tail-cuff plethysmography method from the fourth week. The kidney was dissected for histological analysis (H&E). Mann-Whitney and Student's t-test were used for non-parametric and parametric data, respectively, with a significance level of 5%. Results. A statistically significant increase in both Bowman's space area and renal corpuscle area was found in the AP group (p<0.05). The AP group had a higher percentage of renal tissue with inflammatory infiltrate, but without significant difference. Blood pressure did change during the experimental period and no difference was identified between the groups. Conclusions. Induction of AP in Wistar rats resulted in significant changes of certain renal histological parameters, suggesting a possible interaction between AP and renal tissue that requires further research. [ABSTRACT FROM AUTHOR]
ISSN:	17264634
DOI:	10.17843/rpmesp.2014.314.13947