Bibliographic Details
| Title: |
El ensayo diana para la inferencia causal en estudios observacionales. |
| Alternate Title: |
The target trial framework for causal inference with observational studies. |
| Authors: |
Núñez, Isaac1,2 isaac_nunezsaavedra@g.harvard.edu, Lajous, Martín3,4 |
| Source: |
Salud Pública de México. ene/feb2025, Vol. 67 Issue 1, p83-90. 8p. |
| Subjects: |
CAUSAL inference, RESEARCH questions, SCIENTIFIC observation, CLINICAL trials, CLINICAL epidemiology |
| Abstract (English): |
The use of observational studies for causal inference is a necessity, as randomized trials are not always available or possible to carry out. To reduce sources of bias present in "classical" observational studies, the target trial framework has been proposed. First one defines the following components of the pragmatic clinical trial (the target trial) would answer our research question: eligibility criteria, treatment strategies, assignment, follow-up, outcomes, causal contrast, and statistical analysis plan. Then, these components are modified based on available observational data, and used to emulate the target trial as closely as possible. This leads to observational studies that are generally less biased and with more reliable results. Nonetheless, it is important to consider the limitations of this framework given it is still an observational study and not a randomized experiment. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
El uso de estudios observacionales para inferencia causal es una necesidad, ya que no siempre se cuenta con ensayos clínicos aleatorizados. Para reducir las fuentes de sesgo presentes en estudios observacionales "clásicos" se ha propuesto utilizar el marco de referencia del ensayo diana. Esto es, primero, definir los siguientes componentes del protocolo del ensayo clínico pragmático (el ensayo diana) que respondería nuestra pregunta de investigación: criterios de elegibilidad, estrategias de tratamiento, métodos de asignación, periodo de seguimiento, desenlace, contrastes causales y plan de análisis. Posteriormente, estos componentes se modifican con base en los datos observacionales disponibles y se utilizan para emular al ensayo diana lo más de cerca posible. Esto resulta en estudios observacionales con menos sesgo y resultados más confiables. Sin embargo, siguen tradándose de estudios observacionales y no de experimentos aleatorizados, lo cual les confiere algunas limitaciones. [ABSTRACT FROM AUTHOR] |
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| Database: |
MedicLatina |
