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Elbow osteomyelitis by Candida tropicalis in acute lymphoblastic leukemia. A case report.

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Title: Elbow osteomyelitis by Candida tropicalis in acute lymphoblastic leukemia. A case report.
Alternate Title: Osteomielitis de codo por Candida tropicalis en leucemia linfoblástica aguda. Reporte de un caso.
Authors: Kohan-Fortuna-Figueira, S.1 suryakohan@gmail.com, Latorre, M.1, Dardanelli, P.1, Halliburton, C.1, Bosio, S.1, Puigdevall, M.1
Source: Acta Ortopédica Mexicana. mar/apr2025, Vol. 39 Issue 2, p117-120. 4p.
Subjects: LYMPHOBLASTIC leukemia, CHILD patients, OPPORTUNISTIC infections, ACUTE leukemia, CANDIDA tropicalis
Abstract (English): Introduction: musculoskeletal involvement of the extremities is common in pediatric patients with acute lymphoblastic leukemia. The insidious and oligosymptomatic presentation of several musculoskeletal conditions in these patients often leads to different diagnostic suspicions, which may delay appropriate management of the pathology. Non-albicans Candida osteoarticular infections are a rare entity that may affect immunodeficient patients. We describe a case of osteoarticular infection caused by an opportunistic fungus in a pediatric patient with acute lymphoblastic leukemia during the second week of rest post-consolidation block. Case presentation: we present a case of a 4-year-old girl diagnosed with B-cell acute lymphoblastic leukemia that developed an elbow infection by Candida tropicalis. Two surgical debridements of the elbow, combined with the administration of antifungals, were required to control the infection. She fully recovered at six months postoperatively and remains without osteoarticular sequelae at three years of follow up. Conclusion: C. tropicalis infection should be included in the differential diagnosis of osteoarticular complications in immunocompromised patients with acute lymphoblastic leukemia (ALL). Prompt diagnosis and treatment are essential to avoid osteoarticular sequelae. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción: los síntomas musculoesqueléticos en las extremidades son frecuentes en pacientes pediátricos con leucemia linfoblástica aguda. La presentación insidiosa y oligosintomática de distintas afecciones musculoesqueléticas en estos pacientes genera con frecuencia distintas sospechas diagnósticas que pueden retrasar el manejo adecuado de la patología. Las infecciones osteoarticulares por Candida no albicans son una entidad poco frecuente que puede verse en pacientes inmunocomprometidos. Se describe un caso de infección osteoarticular causada por un hongo oportunista en un paciente pediátrico con leucemia linfoblástica aguda en su segunda semana de descanso postbloqueo de consolidación. Presentación del caso: paciente de cuatro años con antecedente de leucemia linfoblástica aguda en etapa de consolidación, que desarrolla un cuadro oligosintomático de osteomielitis de codo por Candida tropicalis. Se realizaron dos procedimientos quirúrgicos de toilette y desbridamiento del codo asociado a la administración de antifúngicos y antibióticos, presentando una buena evolución a los seis meses postoperatorios sin secuelas óseas luego de tres años de seguimiento. Conclusión: la infección por C. tropicalis debe incluirse en el diagnóstico diferencial de las infecciones osteoarticulares en pacientes inmunocomprometidos. El diagnóstico y tratamiento rápido es primordial para evitar secuelas osteoarticulares. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
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Abstract:Introduction: musculoskeletal involvement of the extremities is common in pediatric patients with acute lymphoblastic leukemia. The insidious and oligosymptomatic presentation of several musculoskeletal conditions in these patients often leads to different diagnostic suspicions, which may delay appropriate management of the pathology. Non-albicans Candida osteoarticular infections are a rare entity that may affect immunodeficient patients. We describe a case of osteoarticular infection caused by an opportunistic fungus in a pediatric patient with acute lymphoblastic leukemia during the second week of rest post-consolidation block. Case presentation: we present a case of a 4-year-old girl diagnosed with B-cell acute lymphoblastic leukemia that developed an elbow infection by Candida tropicalis. Two surgical debridements of the elbow, combined with the administration of antifungals, were required to control the infection. She fully recovered at six months postoperatively and remains without osteoarticular sequelae at three years of follow up. Conclusion: C. tropicalis infection should be included in the differential diagnosis of osteoarticular complications in immunocompromised patients with acute lymphoblastic leukemia (ALL). Prompt diagnosis and treatment are essential to avoid osteoarticular sequelae. [ABSTRACT FROM AUTHOR]
ISSN:23064102
DOI:10.35366/119394