VALIDACIÓN DE LA DETERMINACIÓN YODOMÉTRICA DE HIPOCLORITO DE SODIO EN SOLUCIONES DESINFECTANTES.

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Bibliographic Details
Title:	VALIDACIÓN DE LA DETERMINACIÓN YODOMÉTRICA DE HIPOCLORITO DE SODIO EN SOLUCIONES DESINFECTANTES.
Alternate Title:	VALIDATION OF THE IODOMETRIC DETERMINATION OF SODIUM HYPOCHLORITE IN DISINFECTANT SOLUTIONS.
Authors:	Abalos Rodríguez, Arelis¹ aabalos@uo.edu.cu, Pérez Pompa, Norma¹, Aguilera Rodríguez, Isabel¹, Rodríguez Gámez, Odalys¹
Source:	Revista CENIC Ciencias Quimicas. 2024, Vol. 55, p78-86. 9p.
Subjects:	DETECTION limit, RAW materials, VOLUME (Cubic content), STARCH, DISINFECTION & disinfectants, SODIUM hypochlorite
Abstract (English):	Analytical validation establishes that the performance characteristics of a procedure meet the requirements for the intended applications under the specific laboratory conditions. It is a process, from its conception; rigorous, dependent on the technique, the mat rix, the analyte, the concentration ranges, the parameters to be evaluated, the available infrastructure and the analyst. It is applied to analytical determinations on a finished product or its raw material. The fundamental parameters of an analytical validation are: selectivity, linearity and range, precision, accuracy and limits of detection and quantification: Robustness is a parameter of method tuning. Sodium hypochlorite is a chlorinated compound widely used as an active ingredient in bleaching agents. The classical method for quantifying the hypochlorite content in different samples is iodometric redox volumetry, with starch as indicator. It is a specific method for this analyte. The aim of the work is the validation of the establishment by suitability of the iodometric method for the determination of sodium hypochlorite in disinfectant solutions. The parameters considered were selectivity, precision through repeatability and reproducibility, accuracy, robustness, linearity, range and limits of detection and quantification. It was demonstrated that 85.7% of the parameters met the established acceptance criteria. The preparation time of the sodium thiosulfate titrating solution influenced the quantification of hypochlorite content. The iodometric method for determining sodium hypochlorite concentration in commercial samples is selective, precise, accurate and linear. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	La validación analítica establece que las características de desempeño de un procedimiento cumplen los requisitos para las aplicaciones previstas en las condiciones específicas del laboratorio. Es un proceso, desde su concepción; riguroso, dependiente de la técnica, la matriz, el analito, los intervalos de concentración, los parámetros a evaluar, la infraestructura disponible y el analista. Se aplica a determinaciones analíticas en un producto terminado o a la materia prima de estos. Los parámetros fundamentales de una validación analítica son: selectividad, linealidad y rango, precisión, exactitud y límites de detección y cuantificación: La robustez es un parámetro de la puesta a punto del método. El hipoclorito de sodio es un compuesto clorado muy utilizado como principio activo de agentes blanqueadore s. El método clásico de cuantificación del contenido de hipoclorito en diferentes muestras es la volumetría redox yodométrica, con almidón como indicador. Es un método específico para este analito. El objetivo del trabajo es la validación del establecimiento por adecuación del método yodométrico para la determinación de hipoclorito de sodio en soluciones desinfectantes. Los parámetros considerados fueron selectividad, precisión a través de repetibilidad y reproducibilidad, exactitud, robustez, linealidad, intervalo y los límites de detección y cuantificación. Se demostró que el 85,7% de los parámetros cumplen con el criterio de aceptación establecido. El tiempo de preparación de la solución valorante tiosulfato de sodio influyó en la cuantificación del contenido de hipoclorito. El método yodométrico para determinar la concentración de hipoclorito de sodio en muestras comerciales es selectivo, preciso, exacto y lineal. [ABSTRACT FROM AUTHOR]
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Database:	MedicLatina

Description
Abstract:	Analytical validation establishes that the performance characteristics of a procedure meet the requirements for the intended applications under the specific laboratory conditions. It is a process, from its conception; rigorous, dependent on the technique, the mat rix, the analyte, the concentration ranges, the parameters to be evaluated, the available infrastructure and the analyst. It is applied to analytical determinations on a finished product or its raw material. The fundamental parameters of an analytical validation are: selectivity, linearity and range, precision, accuracy and limits of detection and quantification: Robustness is a parameter of method tuning. Sodium hypochlorite is a chlorinated compound widely used as an active ingredient in bleaching agents. The classical method for quantifying the hypochlorite content in different samples is iodometric redox volumetry, with starch as indicator. It is a specific method for this analyte. The aim of the work is the validation of the establishment by suitability of the iodometric method for the determination of sodium hypochlorite in disinfectant solutions. The parameters considered were selectivity, precision through repeatability and reproducibility, accuracy, robustness, linearity, range and limits of detection and quantification. It was demonstrated that 85.7% of the parameters met the established acceptance criteria. The preparation time of the sodium thiosulfate titrating solution influenced the quantification of hypochlorite content. The iodometric method for determining sodium hypochlorite concentration in commercial samples is selective, precise, accurate and linear. [ABSTRACT FROM AUTHOR]
ISSN:	10158553