Fenotipo hipertensión-obesidad abdominal como indicador de disglucemia y resistencia a la insulina.

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Bibliographic Details
Title:	Fenotipo hipertensión-obesidad abdominal como indicador de disglucemia y resistencia a la insulina.
Alternate Title:	Hypertension-abdominal obesity phenotype as an indicator of dysglycaemia and insulin resistance.
Authors:	Cabrera-Rode, Eduardo¹ (AUTHOR) eduardo.cabrerarode@gmail.com, Javier Loaiza-Romero, Brayam² (AUTHOR) brayamloaiza@gmail.com, Rodríguez-Acosta, Janet³ (AUTHOR) yanetra@infomed.sld.cu, Cubas-Dueñas, Ileana⁴ (AUTHOR) ileana.cubas77@gmail.com, Hernández-Rodríguez, José⁵ (AUTHOR) pepehdez@infomed.sld.cu, Díaz-Díaz, Oscar⁶ (AUTHOR) diazdiaz@infomed.sld.cu
Source:	Revista de Salud Pública. dic2023, Vol. 25 Issue 6, p1-9. 9p. 4 Charts.
Abstract (English):	Objective To determine the usefulness of the hypertension-abdominal obesity phenotype as an indicator of dysglycaemia and insulin resistance. Materials and Methods Cross-sectional descriptive study of 964 adults (449 women and 515 men) who attended the Institute of Endocrinology with risk of diabetes mellitus. Demographic (age, sex, skin colour), clinical (blood pressure and acanthosis nigricans), anthropometric (weight, height, waist circumference and body mass index) and laboratory (basal and oral glucose tolerance test-stimulated blood glucose and insulinaemia) variables were analysed. The insulin resistance index was calculated. The abdominal hypertension-obesity phenotype was defined as the presence of systolic pressure ≥130 mm Hg and/or diastolic pressure ≥80 mm Hg or treated hypertension, waist circumference ≥80 cm in women and ≥90 cm in men. Sensitivity, specificity and predictive values of the abdominal obesity hypertension phenotype were calculated to identify dysglycaemia and insulin resistance. Results Individuals with the hypertension-abdominal obesity phenotype showed a higher proportion of impaired glucose metabolism and insulin resistance than those without the phenotype (p<0.0001). The hypertension-abdominal obesity phenotype better identifies persons with the presence of double prediabetes, diabetes mellitus and insulin resistance, as they show high sensitivities (85.9%, 77.5%, and 68.9%, respectively), and high negatives predictive values (97.9%, 95.8%, and 74.0%, respectively). Conclusions The hypertension-abdominal obesity phenotype is a simple, useful option for identifying persons with dysglycaemia, and insulin resistance. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	Objetivo Determinar la utilidad del fenotipo hipertensión-obesidad abdominal como indicador de disglucemia y resistencia a la insulina. Material y Métodos Estudio descriptivo transversal con 964 personas adultas (449 mujeres y 515 hombres), que asistieron al Instituto de Endocrinología con riesgo de diabetes mellitus. Se analizaron variables demográficas (edad, sexo, color de la piel), clínicas (tensión arterial y Acantosis nigricans), antropométricas (peso, talla, circunferencia de la cintura e índice de masa corporal) y de laboratorio (glucemia basal y estimulada con la prueba de tolerancia a la glucosa oral e insulinemia). Se calculó el índice de resistencia a la insulina. El fenotipo hipertensión-obesidad abdominal se definió como la presencia de presión sistólica ≥130 mm Hg o presión diastólica ≥80 mm Hg o hipertensión arterial tratada, circunferencia de cintura ≥80 cm en mujeres y ≥90 cm en hombres. Se calculó la sensibilidad, la especificidad y los valores predictivos del fenotipo hipertensión obesidad abdominal para identificar disglucemia y resistencia a la insulina. Resultados Los individuos con el fenotipo hipertensión-obesidad abdominal mostraron mayor proporción de alteraciones del metabolismo de la glucosa y de resistencia a la insulina que las personas sin el fenotipo (p<0,0001). El fenotipo hipertensión-obesidad abdominal identifica mejor a personas con presencia de prediabetes doble, diabetes mellitus y resistencia a la insulina, pues muestran sensibilidades altas (85,9%, 77,5%, y 68,9%, respectivamente) y valores predictivos negativos altos (97,9%, 95,8%, y 74,0%, respectivamente). Conclusiones El fenotipo hipertensión-obesidad abdominal es una opción sencilla, útil para identificar a personas con disglucemia y resistencia a la insulina. [ABSTRACT FROM AUTHOR]
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Database:	MedicLatina

Description
Abstract:	Objective To determine the usefulness of the hypertension-abdominal obesity phenotype as an indicator of dysglycaemia and insulin resistance. Materials and Methods Cross-sectional descriptive study of 964 adults (449 women and 515 men) who attended the Institute of Endocrinology with risk of diabetes mellitus. Demographic (age, sex, skin colour), clinical (blood pressure and acanthosis nigricans), anthropometric (weight, height, waist circumference and body mass index) and laboratory (basal and oral glucose tolerance test-stimulated blood glucose and insulinaemia) variables were analysed. The insulin resistance index was calculated. The abdominal hypertension-obesity phenotype was defined as the presence of systolic pressure ≥130 mm Hg and/or diastolic pressure ≥80 mm Hg or treated hypertension, waist circumference ≥80 cm in women and ≥90 cm in men. Sensitivity, specificity and predictive values of the abdominal obesity hypertension phenotype were calculated to identify dysglycaemia and insulin resistance. Results Individuals with the hypertension-abdominal obesity phenotype showed a higher proportion of impaired glucose metabolism and insulin resistance than those without the phenotype (p<0.0001). The hypertension-abdominal obesity phenotype better identifies persons with the presence of double prediabetes, diabetes mellitus and insulin resistance, as they show high sensitivities (85.9%, 77.5%, and 68.9%, respectively), and high negatives predictive values (97.9%, 95.8%, and 74.0%, respectively). Conclusions The hypertension-abdominal obesity phenotype is a simple, useful option for identifying persons with dysglycaemia, and insulin resistance. [ABSTRACT FROM AUTHOR]
ISSN:	01240064
DOI:	10.15446/rsap.V25n6.110831