View in EDS PDF Full Text

Resistencia antifúngica de levaduras aisladas en onicomicosis. Efecto del tratamiento previo.

Saved in:
Bibliographic Details
Title: Resistencia antifúngica de levaduras aisladas en onicomicosis. Efecto del tratamiento previo.
Alternate Title: Antifungal resistance of yeasts isolated from onychomycosis. Effect of previous treatment.
Authors: García Pérez, Daniel Ricardo, Méndez Tovar, Luis Javier, Hernández Hernández, Francisca1, Manzano Gayosso, Patricia1 angelesmg@unam.mx, Baudouy, Coralie2, Silva González, Israel3
Source: Dermatología Revista Mexicana. mar/apr2025, Vol. 69 Issue 2, p169-177. 9p.
Abstract (English): OBJECTIVE: To determine the influence of previous administration of antifungals on fungal resistance. MATERIALS AND METHODS: A cross-sectional, analytical, and prospective study was conducted from January 2018 to December 2019 in outpatients treated in the Dermatology Department and in patients hospitalized for another underlying disease at the Specialty Hospital of the National Medical Center Siglo XXI (IMSS), diagnosed with onychomycosis. Only yeastlike cultures were considered for this study. The measured variables were immunosuppression, evolution time, clinical form of onychomycosis and previous exposure to antifungal drugs. Identification was determined by phenotypic tests (germ-tube, pseudohyphae and chlamydospore formation), colony aspect and color on CHROMagar Candida and by the Vitek 2 system. Antifungal susceptibility was determined by broth microdilution (CLSI, document M27 A3). For statistical analysis χ² and U of Mann-Whitney tests were used. RESULTS: Forty yeast isolates were obtained, 18 were related to previous exposure to antifungal drugs. Global resistance occurred in 12/40 isolates; however, among patients with previous exposure this was observed in 30/40 (p = 0.015). The other factors showed no correlation with this increase of resistance. CONCLUSIONS: The increase of resistance of isolates coming from onychomycosis patients showed association with previous antifungal drugs administration. For the first time Candida galli (current Yarrowia galli) is reported as onychomycosis agent in Mexico. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): OBJETIVO: Determinar la influencia de la administración previa de antifúngicos en la resistencia antifúngica. MATERIALES Y MÉTODOS: Estudio transversal, analítico y prospectivo, efectuado de enero de 2018 a diciembre de 2019 en pacientes externos, atendidos en el Servicio de Dermatología, y en pacientes hospitalizados por otra enfermedad subyacente en el Hospital de Especialidades del Centro Médico Nacional Siglo XXI, IMSS, con diagnóstico de onicomicosis. Sólo se incluyeron los cultivos levaduriformes. Las variables medidas fueron la inmunosupresión, tiempo de evolución, forma clínica de la onicomicosis y exposición a antimicóticos. La identificación fue por pruebas fenotípicas (formación de tubo germinativo, pseudohifas y clamidoconidios), aspecto y color de la colonia en CHROMagar Candida y por el sistema Vitek 2. La sensibilidad a antifúngicos se determinó por microdilución en caldo (CLSI, documento M27 A3). Se utilizaron las pruebas χ² y U de Mann-Whitney. RESULTADOS: Se obtuvieron 40 aislamientos levaduriformes, 18 relacionados con exposición previa a antifúngicos. Hubo resistencia en 12 de 40 aislamientos; no obstante, entre los pacientes con exposición previa, ésta ocurrió en 30 de 40 (p = 0.015). Los otros factores no mostraron asociación con este aumento de resistencia. CONCLUSIONES: La resistencia en los aislamientos provenientes de pacientes con onicomicosis mostró correlación con la administración previa de antifúngicos. Se reporta por primera vez a Candida galli (actual Yarrowia galli) como causa de onicomicosis en México. [ABSTRACT FROM AUTHOR]
Copyright of Dermatología Revista Mexicana is the property of Edicion y Farmacia S.A. de C.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
Description
Abstract:OBJECTIVE: To determine the influence of previous administration of antifungals on fungal resistance. MATERIALS AND METHODS: A cross-sectional, analytical, and prospective study was conducted from January 2018 to December 2019 in outpatients treated in the Dermatology Department and in patients hospitalized for another underlying disease at the Specialty Hospital of the National Medical Center Siglo XXI (IMSS), diagnosed with onychomycosis. Only yeastlike cultures were considered for this study. The measured variables were immunosuppression, evolution time, clinical form of onychomycosis and previous exposure to antifungal drugs. Identification was determined by phenotypic tests (germ-tube, pseudohyphae and chlamydospore formation), colony aspect and color on CHROMagar Candida and by the Vitek 2 system. Antifungal susceptibility was determined by broth microdilution (CLSI, document M27 A3). For statistical analysis χ² and U of Mann-Whitney tests were used. RESULTS: Forty yeast isolates were obtained, 18 were related to previous exposure to antifungal drugs. Global resistance occurred in 12/40 isolates; however, among patients with previous exposure this was observed in 30/40 (p = 0.015). The other factors showed no correlation with this increase of resistance. CONCLUSIONS: The increase of resistance of isolates coming from onychomycosis patients showed association with previous antifungal drugs administration. For the first time Candida galli (current Yarrowia galli) is reported as onychomycosis agent in Mexico. [ABSTRACT FROM AUTHOR]
ISSN:01854038
DOI:10.24245/dermatolrevmex.v69i2.10435