Eje cerebro-intestino-piel y el papel de la microbiota humana en algunas enfermedades cutáneas.

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Bibliographic Details
Title:	Eje cerebro-intestino-piel y el papel de la microbiota humana en algunas enfermedades cutáneas.
Alternate Title:	Brain-gut-skin axis and the role of the human microbiota in some skin diseases.
Authors:	Neira Moreno, Jessica Paola¹ jeyneira@hotmail.es, Velásquez Lopera, Margarita María²
Source:	Dermatología Revista Mexicana. may/jun2025, Vol. 69 Issue 3, p351-360. 10p.
Subjects:	GUT microbiota, EMOTIONAL conditioning, ALOPECIA areata, ATOPIC dermatitis, ENVIRONMENTAL exposure
Abstract (English):	BACKGROUND: Dysbiosis has been related to inflammation and an increase in diseases such as acne, alopecia areata, psoriasis and atopic dermatitis. One of the main regulators of the skin microbiota is the gut microbiota and this, in turn, is influenced by the brain, this is called the brain-gut-skin axis, which contributes to the state of health of the body. OBJECTIVE: To show the fundamental aspects of the brain-gut-skin axis. METHODOLOGY: Narrative review of the literature in which articles were searched in the PubMed, SciELO and Google Scholar databases using the terms "brain-gut-skin axis", "skin and gut microbiota", "microbiome", and "microbiota and diseases". There were no restrictions on the language or publication location of the study. RESULTS: There were selected 35 articles, including Colombian bibliography. The skin and the intestine are two very similar organs due to their large extension, their barrier function, contact with the external environment and neuroendocrine and immune functions, and they are also in contact with the microbiota. The microbiota is diverse and dynamic, changing according to anatomical area, age, hygiene, diet, environmental exposure and some cultural practices. Emotional stimuli contribute to dysbiosis and this, in turn, also generates changes. CONCLUSIONS: The role of the microbiota and the gut-brain-skin axis is a topic of growing interest. Some interventions have been found to be useful; however, there is still a lack of studies to modulate it appropriately in each patient. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	ANTECEDENTES: La disbiosis se ha relacionado con inflamación e incremento de enfermedades como acné, alopecia areata, psoriasis y dermatitis atópica. Uno de los principales reguladores de la microbiota cutánea es la microbiota intestinal y ésta, a su vez, está influenciada por el cerebro; a esto se le denomina eje cerebro-intestino-piel, que contribuye al estado de salud del organismo. OBJETIVO: Mostrar los aspectos fundamentales del eje cerebro-intestino-piel. METODOLOGÍA: Revisión narrativa de la bibliografía en la que se buscaron artículos en las bases de datos PubMed, SciELO y Google Scholar con los términos "eje cerebro-intestino-piel", "microbiota piel e intestino", "microbioma" y "microbiota y enfermedades". No hubo restricción en el idioma o lugar de publicación del estudio. RESULTADOS: Se seleccionaron 35 artículos, incluida bibliografía colombiana. La piel y el intestino son órganos muy similares por su gran extensión, su función de barrera, el contacto con el medio externo y las funciones neuroendocrinas e inmunitarias; además, están en contacto con la microbiota. La microbiota es diversa y dinámica, cambia según la zona anatómica, la edad, la higiene, la dieta, la exposición ambiental y algunas prácticas culturales. Los estímulos emocionales contribuyen a generar disbiosis y ésta, a su vez, también origina cambios que repercuten en la esfera mental. CONCLUSIONES: El papel de la microbiota y el eje intestino-cerebro-piel es un tema de interés creciente. Algunas intervenciones han resultado útiles; sin embargo, aún faltan estudios para modularlo apropiadamente en cada paciente. [ABSTRACT FROM AUTHOR]
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Database:	MedicLatina

Description
Abstract:	BACKGROUND: Dysbiosis has been related to inflammation and an increase in diseases such as acne, alopecia areata, psoriasis and atopic dermatitis. One of the main regulators of the skin microbiota is the gut microbiota and this, in turn, is influenced by the brain, this is called the brain-gut-skin axis, which contributes to the state of health of the body. OBJECTIVE: To show the fundamental aspects of the brain-gut-skin axis. METHODOLOGY: Narrative review of the literature in which articles were searched in the PubMed, SciELO and Google Scholar databases using the terms "brain-gut-skin axis", "skin and gut microbiota", "microbiome", and "microbiota and diseases". There were no restrictions on the language or publication location of the study. RESULTS: There were selected 35 articles, including Colombian bibliography. The skin and the intestine are two very similar organs due to their large extension, their barrier function, contact with the external environment and neuroendocrine and immune functions, and they are also in contact with the microbiota. The microbiota is diverse and dynamic, changing according to anatomical area, age, hygiene, diet, environmental exposure and some cultural practices. Emotional stimuli contribute to dysbiosis and this, in turn, also generates changes. CONCLUSIONS: The role of the microbiota and the gut-brain-skin axis is a topic of growing interest. Some interventions have been found to be useful; however, there is still a lack of studies to modulate it appropriately in each patient. [ABSTRACT FROM AUTHOR]
ISSN:	01854038
DOI:	10.24245/dermatolrevmex.v69i3.10515