SODIUM AND MENOPAUSE. DOPAMINE D1-RECEPTORS, NA+-K+-ATPASE AND CD4+ IN PERIPHERAL BLOOD AS MARKERS OF RENAL INFLAMMATION.
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| Title: | SODIUM AND MENOPAUSE. DOPAMINE D1-RECEPTORS, NA+-K+-ATPASE AND CD4+ IN PERIPHERAL BLOOD AS MARKERS OF RENAL INFLAMMATION. |
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| Alternate Title: | Sodio y menopausia. Receptores de dopamina D1, Na+-K+-ATPasa y CD4+ en sangre periférica como marcadores de nflamación renal. |
| Authors: | VLACHOVSKY, SANDRA G.1,2 sandragvla@gmail.com, IBARRA, FERNANDO R.1,3, CIANO, LUIS DI1,4 |
| Source: | Medicina (Buenos Aires). may/jun2025, Vol. 85 Issue 3, p550-555. 6p. |
| Subjects: | IMMUNOREGULATION, ESTROGEN regulation, BLOOD pressure, MENOPAUSE, DRUG therapy |
| Abstract (English): | It has been observed that menopausal women have a greater sensitivity to sodium intake than women in fertile age. Furthermore, it is now known that the immune system activated by high sodium intake plays an essential role in the development of hypertension. Changes observed in components of the immune system in an animal model of menopause, show the key role of estrogens in the regulation of the immune response to a high salt load. Faced with the same challenge, intact rats have adequate renal sodium management, and the immune system is not activated, while hormone-deprived rats retain sodium and show a pro-inflammatory profile. Pharmacological treatment of hypertension reduces blood pressure, but the observed renal damage remains. Therefore, menopausal women should be especially advised to have an adequate sodium intake that does not pose a risk to their health. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Se ha observado que las mujeres menopaúsicas tienen una sensibilidad mayor al consumo de sodio que las mujeres en edad fértil. Por otra parte, actualmente se conoce que el sistema inmune, asociado a una ingesta elevada de sodio, desempeña un papel esencial en el desarrollo de hipertensión. Los cambios observados en componentes del sistema inmune en un modelo experimental de menopausia evidencian el papel clave de los estrógenos en la regulación de la respuesta inmune ante una carga elevada de sal. Ante el mismo desafío, las ratas intactas tienen un manejo renal adecuado del sodio y el sistema inmune no se activa, mientras que las ratas privadas de hormonas retienen sodio y muestran un perfil proinflamatorio. El tratamiento farmacológico de la hipertensión logra reducir la presión arterial, pero se mantiene el daño renal observado. Las mujeres menopaúsicas deberían ser especialmente alertadas para tener un consumo adecuado de sodio que no represente un riesgo para su salud. [ABSTRACT FROM AUTHOR] |
| Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Abstract: | It has been observed that menopausal women have a greater sensitivity to sodium intake than women in fertile age. Furthermore, it is now known that the immune system activated by high sodium intake plays an essential role in the development of hypertension. Changes observed in components of the immune system in an animal model of menopause, show the key role of estrogens in the regulation of the immune response to a high salt load. Faced with the same challenge, intact rats have adequate renal sodium management, and the immune system is not activated, while hormone-deprived rats retain sodium and show a pro-inflammatory profile. Pharmacological treatment of hypertension reduces blood pressure, but the observed renal damage remains. Therefore, menopausal women should be especially advised to have an adequate sodium intake that does not pose a risk to their health. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00257680 |
