Bibliographic Details
| Title: |
Medicamentos para el sistema nervioso con riesgo fetal: su uso antes y durante el embarazo en un seguro social argentino. |
| Alternate Title: |
Use of nervous system medications with fetal risk before and during pregnancy in an Argentine social security system. |
| Authors: |
Alvarez Rotondo, Cecilia Anahi1 anahi.alvarez.rotondo@gmail.com, Marín, Gustavo H.2,3, Marín, Lupe2,4, Mollo, Solange3, Urtasun, Martín A.5, Cañás, Martín5,6 |
| Source: |
Revista Colombiana de Obstetricia y Ginecologia. abr-jun2025, Vol. 76 Issue 2, p1-12. 12p. |
| Subjects: |
PREGNANCY, HIGH-risk pregnancy, PRENATAL drug exposure, HEALTH insurance, DRUG utilization, PSYCHIATRIC drugs |
| Geographic Terms: |
ARGENTINA |
| Abstract (English): |
Objective: To describe the dispensing of nervous system medications before and during pregnancy, according to the fetal risk category of the drug. Material and methods: Descriptive drug utilization study of nervous system medications in a historical cohort (2020-2023) of pregnant women enrolled in a health insurance program in Argentina. Dispensed drugs were categorized into two groups: high fetal risk and non-high or unknown risk, based on the classification of selected regulatory agencies. The prevalence of use before and during pregnancy was measured, along with the cumulative incidence of drug discontinuation and initiation during pregnancy. Results: Among the 6,369 pregnant women included, 4.7% received at least one drug from the evaluated group in the pre-pregnancy period, and 18.8% during pregnancy. This increase was mainly due to paracetamol, which rose from 1.5% to 13.4% during pregnancy. In contrast, the use of anxiolytics (1.6% to 0.7%), antidepressants (0.8% to 0.4%), and antiepileptics (0.7% to 0.4%) decreased. The prevalence of use of high-risk medications declined from 1.5% to 1% during pregnancy, with a cumulative discontinuation incidence of 81.3% and initiation incidence of 0.7%. Conclusions: The dispensing of nervous system medications with high fetal risk was low in the studied cohort. Identifying the fetal risk associated with each drug is essential to optimize treatment selection for nervous system disorders in pregnant women. Prospective studies are needed to validate medication utilization patterns in the region and their associated fetal and neonatal outcomes. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
Objetivo: describir la dispensación de fármacos para el sistema nervioso antes y durante el embarazo, según la categoría de riesgo fetal del medicamento. Materiales y métodos: estudio descriptivo de utilización de medicamentos para el sistema nervioso en una cohorte histórica (2020-2023) de mujeres embarazadas, en un seguro de salud de Argentina. Los fármacos dispensados fueron categorizados en un grupo de riesgo fetal alto, y otro de no alto o desconocido, de acuerdo con la clasificación de agencias reguladoras seleccionadas. Se midió la prevalencia de uso antes y durante la gestación, así como la incidencia acumulada de retiro y de inicio durante el embarazo. Resultados: de las 6.369 embarazadas incluidas, el 4,7 % recibió algún fármaco del grupo evaluado en el periodo previo y 18,8 % durante el embarazo. Este aumento se debió principalmente al paracetamol, que ascendió de 1,5 a 13,4 % durante el embarazo. Por el contrario, descendió el uso de ansiolíticos (1,6 a 0,7 %), antidepresivos (0,8 a 0,4 %) y antiepilépticos (0,7 a 0,4 %). La prevalencia de uso de medicamentos de alto riesgo descendió de 1,5 a 1 % durante el embarazo, con una incidencia acumulada de retiro de 81,3 % y de inicio del 0,7 %. Conclusiones: la dispensación de medicamentos para el sistema nervioso con alto riesgo fetal fue baja en la cohorte estudiada. Es importante identificar el riesgo fetal de cada medicamento a fin de optimizar la selección del tratamiento para los trastornos del sistema nervioso en las mujeres gestantes. Se requieren estudios prospectivos que validen los patrones de utilización de medicamentos en la región y los desenlaces fetales y neonatales. [ABSTRACT FROM AUTHOR] |
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| Database: |
MedicLatina |
