Usefulness of monocyte distribution width (MDW) in enhancing diagnostic accuracy of infection among severely ill patients presenting to the emergency department.

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Title: Usefulness of monocyte distribution width (MDW) in enhancing diagnostic accuracy of infection among severely ill patients presenting to the emergency department.
Alternate Title: Utilidad de la amplitud de distribución de monocitos (MDW) para mejorar la precisión diagnóstica de la infección en pacientes graves atendidos en el servicio de urgencias.
Authors: González del Castillo, Juan1 jgonzalezcast@gmail.com, del Toro, Enrique2, Fragiel, Marcos2, Oteo, David2, García-Álvarez, Ana3
Source: Revista Española de Quimioterapia. 2025 Supplement, Vol. 38, p5-10. 6p.
Subjects: INFECTION, SEPSIS, BIOMARKERS, HOSPITAL emergency services, DIAGNOSIS, IMMUNE response, CRITICALLY ill patient care
Abstract (English): Sepsis remains a major cause of morbidity and mortality and continues to pose substantial diagnostic challenges in its early stages. Monocyte Distribution Width (MDW), a parameter automatically integrated into complete blood counts by next generation haematology analysers, has emerged as a promising biomarker. This study evaluates the diagnostic performance of MDW compared with traditional markers (C-reactive protein and leukocyte count) and clinical scoring systems (SOFA and NEWS) in a cohort of critically ill patients presenting to a hospital emergency department, with the aim of distinguishing those with infection from those whose severity was attributable to other causes. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): La sepsis continúa siendo una causa relevante de morbimortalidad con dificultades diagnósticas relevantes en fases precoces. El parámetro MDW (Monocyte Distribution Width), integrado automáticamente en hemogramas de analizadores de última generación, ha emergido como un biomarcador prometedor. Este estudio analiza el rendimiento diagnóstico de MDW comparado con otros marcadores clásicos (proteína C reactiva y leucocitos) y escalas clínicas (SOFA y NEWS) en una cohorte de pacientes con criterios de gravedad atendidos en un Servicio de Urgencias Hospitalario para identificar pacientes con infección frente a los que presentan otro origen de su situación de gravedad. [ABSTRACT FROM AUTHOR]
Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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  Label: Title
  Group: Ti
  Data: Usefulness of monocyte distribution width (MDW) in enhancing diagnostic accuracy of infection among severely ill patients presenting to the emergency department.
– Name: TitleAlt
  Label: Alternate Title
  Group: TiAlt
  Data: Utilidad de la amplitud de distribución de monocitos (MDW) para mejorar la precisión diagnóstica de la infección en pacientes graves atendidos en el servicio de urgencias.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22González+del+Castillo%2C+Juan%22">González del Castillo, Juan</searchLink><relatesTo>1</relatesTo><i> jgonzalezcast@gmail.com</i><br /><searchLink fieldCode="AR" term="%22del+Toro%2C+Enrique%22">del Toro, Enrique</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Fragiel%2C+Marcos%22">Fragiel, Marcos</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Oteo%2C+David%22">Oteo, David</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22García-Álvarez%2C+Ana%22">García-Álvarez, Ana</searchLink><relatesTo>3</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Revista+Española+de+Quimioterapia%22">Revista Española de Quimioterapia</searchLink>. 2025 Supplement, Vol. 38, p5-10. 6p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22INFECTION%22">INFECTION</searchLink><br /><searchLink fieldCode="DE" term="%22SEPSIS%22">SEPSIS</searchLink><br /><searchLink fieldCode="DE" term="%22BIOMARKERS%22">BIOMARKERS</searchLink><br /><searchLink fieldCode="DE" term="%22HOSPITAL+emergency+services%22">HOSPITAL emergency services</searchLink><br /><searchLink fieldCode="DE" term="%22DIAGNOSIS%22">DIAGNOSIS</searchLink><br /><searchLink fieldCode="DE" term="%22IMMUNE+response%22">IMMUNE response</searchLink><br /><searchLink fieldCode="DE" term="%22CRITICALLY+ill+patient+care%22">CRITICALLY ill patient care</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Sepsis remains a major cause of morbidity and mortality and continues to pose substantial diagnostic challenges in its early stages. Monocyte Distribution Width (MDW), a parameter automatically integrated into complete blood counts by next generation haematology analysers, has emerged as a promising biomarker. This study evaluates the diagnostic performance of MDW compared with traditional markers (C-reactive protein and leukocyte count) and clinical scoring systems (SOFA and NEWS) in a cohort of critically ill patients presenting to a hospital emergency department, with the aim of distinguishing those with infection from those whose severity was attributable to other causes. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: La sepsis continúa siendo una causa relevante de morbimortalidad con dificultades diagnósticas relevantes en fases precoces. El parámetro MDW (Monocyte Distribution Width), integrado automáticamente en hemogramas de analizadores de última generación, ha emergido como un biomarcador prometedor. Este estudio analiza el rendimiento diagnóstico de MDW comparado con otros marcadores clásicos (proteína C reactiva y leucocitos) y escalas clínicas (SOFA y NEWS) en una cohorte de pacientes con criterios de gravedad atendidos en un Servicio de Urgencias Hospitalario para identificar pacientes con infección frente a los que presentan otro origen de su situación de gravedad. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.37201/req/s01.01.2025
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 6
        StartPage: 5
    Subjects:
      – SubjectFull: INFECTION
        Type: general
      – SubjectFull: SEPSIS
        Type: general
      – SubjectFull: BIOMARKERS
        Type: general
      – SubjectFull: HOSPITAL emergency services
        Type: general
      – SubjectFull: DIAGNOSIS
        Type: general
      – SubjectFull: IMMUNE response
        Type: general
      – SubjectFull: CRITICALLY ill patient care
        Type: general
    Titles:
      – TitleFull: Usefulness of monocyte distribution width (MDW) in enhancing diagnostic accuracy of infection among severely ill patients presenting to the emergency department.
        Type: main
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      – PersonEntity:
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            NameFull: González del Castillo, Juan
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            NameFull: del Toro, Enrique
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            NameFull: Fragiel, Marcos
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            NameFull: Oteo, David
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            NameFull: García-Álvarez, Ana
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            – D: 02
              M: 10
              Text: 2025 Supplement
              Type: published
              Y: 2025
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              Value: 02143429
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              Value: 38
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