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Domestic hypersensitivity pneumonitis caused by inadvertent exposure to feathers.

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Title: Domestic hypersensitivity pneumonitis caused by inadvertent exposure to feathers.
Alternate Title: Neumonitis por hipersensibilidad doméstica causada por exposición accidental a plumas.
Authors: Pose, Katherine1 kattypose@gmail.com, De Las Vecillas, Leticia1,2, Tomás-Pérez, Margarita1, Barranco, Pilar1,2,3, Quirce, Santiago1,2,3, Domínguez-Ortega, Javier1,2,3
Source: Revista Alergia de Mexico. oct-dic2025, Vol. 72 Issue 4, p276-280. 5p.
Subjects: HYPERSENSITIVITY pneumonitis, FEATHERS, DIAGNOSIS, TREATMENT effectiveness, SCIENTIFIC observation, INTERDISCIPLINARY research
Abstract (English): Objective: Case series of patients with domestic hypersensitivity pneumonitis, focusing on hidden avian exposures or other non-suspected antigens (feather comforters and pillows). Methods: Seven female patients diagnosed with non-occupational HP were evaluated using clinical records from La Paz University Hospital (2014-2022). Data collected included exposure history, HRCT findings, IgG antibodies, BAL, biopsies, and treatment outcomes. Results: Patients had a median age of 53.5 years (range: 15-75), with varied exposure to birds or indirect sources like feather duvets. Diagnosis was made based on HRCT, BAL, and biopsy findings. Five patients removed the antigen source, resulting in symptom improvement and pulmonary function in non-fibrotic cases. Corticosteroid treatment was given to all, with one patient requiring oxygen therapy. The median FEV1 improvement was 50 ml, and three patients with a non-fibrotic pattern showed improved DLCO after treatment. Conclusions: Early diagnosis and antigen avoidance are key to managing hypersensitivity pneumonitis (HP), especially in cases of hidden bird-related exposures. A multidisciplinary approach improved outcomes, particularly in non-fibrotic cases. Larger studies and broader antigen testing are needed to validate these findings and enhance diagnostic accuracy. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Objetivo: Serie de casos de pacientes con neumonitis por hipersensibilidad doméstica, enfocándose en exposiciones aviares ocultas u otros antígenos no sospechosos (edredones y almohadas de plumas). Métodos: Se evaluaron siete pacientes femeninas diagnosticadas con neumonitis por hipersensibilidad no ocupacional. Se utilizaron los registros clínicos del Hospital Universitario La Paz (2014-2022). Se recolectaron datos del antecedente de de exposición, hallazgos en HRCT, anticuerpos IgG, BAL, biopsias y resultados del tratamiento. Resultados: Se registró una edad media de 53.5 años (rango: 15-75). Las pacientes tuvieron diversas exposiciones a aves o fuentes indirectas (edredones de plumas). El diagnóstico se basó en los hallazgos de HRCT, BAL y biopsia. Cinco pacientes eliminaron la fuente del antígeno, lo que resultó en la disminución de síntomas y mejora en la función pulmonar en los casos no fibrosos. Se administraron corticosteroides a todas, y una paciente requirió terapia con oxígeno. La mejora media del FEV1 fue de 50 mL, y tres pacientes con patrón no fibroso mostraron una mejora en la DLCO luego del tratamiento. Conclusiones: El diagnóstico temprano y evitar el contacto con el antígeno son importantes en el tratamiento de pacientes con neumonitis por hipersensibilidad, especialmente en quienes tienen exposiciones ocultas relacionadas con aves. El enfoque multidisciplinario mejora los resultados, particularmente en casos no fibróticos. Se requieren estudios con muestras más grandes y que realicen pruebas de antígenos más diversas para validar estos hallazgos y mejorar la precisión diagnóstica. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
Description
Abstract:Objective: Case series of patients with domestic hypersensitivity pneumonitis, focusing on hidden avian exposures or other non-suspected antigens (feather comforters and pillows). Methods: Seven female patients diagnosed with non-occupational HP were evaluated using clinical records from La Paz University Hospital (2014-2022). Data collected included exposure history, HRCT findings, IgG antibodies, BAL, biopsies, and treatment outcomes. Results: Patients had a median age of 53.5 years (range: 15-75), with varied exposure to birds or indirect sources like feather duvets. Diagnosis was made based on HRCT, BAL, and biopsy findings. Five patients removed the antigen source, resulting in symptom improvement and pulmonary function in non-fibrotic cases. Corticosteroid treatment was given to all, with one patient requiring oxygen therapy. The median FEV1 improvement was 50 ml, and three patients with a non-fibrotic pattern showed improved DLCO after treatment. Conclusions: Early diagnosis and antigen avoidance are key to managing hypersensitivity pneumonitis (HP), especially in cases of hidden bird-related exposures. A multidisciplinary approach improved outcomes, particularly in non-fibrotic cases. Larger studies and broader antigen testing are needed to validate these findings and enhance diagnostic accuracy. [ABSTRACT FROM AUTHOR]
ISSN:00025151
DOI:10.29262/ram.v72i4.1462