Acute Kidney Injury in children with diabetic ketoacidosis at onset and diabetic kidney disease: a case-control study.

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Bibliographic Details
Title:	Acute Kidney Injury in children with diabetic ketoacidosis at onset and diabetic kidney disease: a case-control study.
Alternate Title:	Lesión Renal Aguda en niños que debutan con cetoacidosis diabética y enfermedad renal por diabetes: estudio de casos y controles.
Authors:	Mannucci, Carla¹ carlamannucci@yahoo.com.ar, Eugenia Andrés, María¹, Ferraro, Mabel¹, Balestracci, Alejandro²
Source:	Andes Pediatrica. nov/dic2025, Vol. 96 Issue 6, p787-793. 7p.
Subjects:	ACUTE kidney failure, DIABETIC nephropathies, CASE-control method, DIABETIC acidosis, TYPE 1 diabetes, PEDIATRIC nephrology, GLYCOSYLATED hemoglobin, KIDNEY diseases
Abstract:	During diabetic ketoacidosis (DKA), acute kidney injury (AKI) may occur. Objective: To evaluate the association between the presence and severity of AKI during the onset of DKA in patients with type 1 diabetes (T1D) and the development of diabetic kidney disease (DKD). Patients and Method: Case-control study. Patients with T1D who presented with DKA at onset and later developed DKD were identified from a local database. Controls were T1D patients with DKA at onset but without DKD. The presence of AKI at onset was assessed as a factor associated with DKD. Exclusion criteria included missing critical data in medical records, follow-up shorter than 8 years from the onset, kidney disease of a different etiology, and/or initial treatment at a different center. The outcome measure was renal status (presence or absence of DKD) at 8 years after T1D onset. Results: Seventeen cases and 42 controls were studied; 22 patients developed AKI. Cases had higher HbA1c levels from the onset (p = 0.004) and a higher frequency (p = 0.001) and severity (p = 0.012) of AKI during DKA. Only AKI (OR 5.4, 95% CI 1.18-24.6; p = 0.02) remained independently associated with DKD. Conclusion: AKI during the onset of DKA in T1D patients was associated with the development of DKD. [ABSTRACT FROM AUTHOR]
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Database:	MedicLatina

Description
Abstract:	During diabetic ketoacidosis (DKA), acute kidney injury (AKI) may occur. Objective: To evaluate the association between the presence and severity of AKI during the onset of DKA in patients with type 1 diabetes (T1D) and the development of diabetic kidney disease (DKD). Patients and Method: Case-control study. Patients with T1D who presented with DKA at onset and later developed DKD were identified from a local database. Controls were T1D patients with DKA at onset but without DKD. The presence of AKI at onset was assessed as a factor associated with DKD. Exclusion criteria included missing critical data in medical records, follow-up shorter than 8 years from the onset, kidney disease of a different etiology, and/or initial treatment at a different center. The outcome measure was renal status (presence or absence of DKD) at 8 years after T1D onset. Results: Seventeen cases and 42 controls were studied; 22 patients developed AKI. Cases had higher HbA1c levels from the onset (p = 0.004) and a higher frequency (p = 0.001) and severity (p = 0.012) of AKI during DKA. Only AKI (OR 5.4, 95% CI 1.18-24.6; p = 0.02) remained independently associated with DKD. Conclusion: AKI during the onset of DKA in T1D patients was associated with the development of DKD. [ABSTRACT FROM AUTHOR]
ISSN:	24526045
DOI:	10.32641/andespediatr.v96i6.5492