Acute Kidney Injury in children with diabetic ketoacidosis at onset and diabetic kidney disease: a case-control study.
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| Title: | Acute Kidney Injury in children with diabetic ketoacidosis at onset and diabetic kidney disease: a case-control study. |
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| Alternate Title: | Lesión Renal Aguda en niños que debutan con cetoacidosis diabética y enfermedad renal por diabetes: estudio de casos y controles. |
| Authors: | Mannucci, Carla1 carlamannucci@yahoo.com.ar, Eugenia Andrés, María1, Ferraro, Mabel1, Balestracci, Alejandro2 |
| Source: | Andes Pediatrica. nov/dic2025, Vol. 96 Issue 6, p787-793. 7p. |
| Subjects: | ACUTE kidney failure, DIABETIC nephropathies, CASE-control method, DIABETIC acidosis, TYPE 1 diabetes, PEDIATRIC nephrology, GLYCOSYLATED hemoglobin, KIDNEY diseases |
| Abstract: | During diabetic ketoacidosis (DKA), acute kidney injury (AKI) may occur. Objective: To evaluate the association between the presence and severity of AKI during the onset of DKA in patients with type 1 diabetes (T1D) and the development of diabetic kidney disease (DKD). Patients and Method: Case-control study. Patients with T1D who presented with DKA at onset and later developed DKD were identified from a local database. Controls were T1D patients with DKA at onset but without DKD. The presence of AKI at onset was assessed as a factor associated with DKD. Exclusion criteria included missing critical data in medical records, follow-up shorter than 8 years from the onset, kidney disease of a different etiology, and/or initial treatment at a different center. The outcome measure was renal status (presence or absence of DKD) at 8 years after T1D onset. Results: Seventeen cases and 42 controls were studied; 22 patients developed AKI. Cases had higher HbA1c levels from the onset (p = 0.004) and a higher frequency (p = 0.001) and severity (p = 0.012) of AKI during DKA. Only AKI (OR 5.4, 95% CI 1.18-24.6; p = 0.02) remained independently associated with DKD. Conclusion: AKI during the onset of DKA in T1D patients was associated with the development of DKD. [ABSTRACT FROM AUTHOR] |
| Copyright of Andes Pediatrica is the property of Revista Chilena de Pediatria and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 191677868 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Acute Kidney Injury in children with diabetic ketoacidosis at onset and diabetic kidney disease: a case-control study. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Lesión Renal Aguda en niños que debutan con cetoacidosis diabética y enfermedad renal por diabetes: estudio de casos y controles. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Mannucci%2C+Carla%22">Mannucci, Carla</searchLink><relatesTo>1</relatesTo><i> carlamannucci@yahoo.com.ar</i><br /><searchLink fieldCode="AR" term="%22Eugenia+Andrés%2C+María%22">Eugenia Andrés, María</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ferraro%2C+Mabel%22">Ferraro, Mabel</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Balestracci%2C+Alejandro%22">Balestracci, Alejandro</searchLink><relatesTo>2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Andes+Pediatrica%22">Andes Pediatrica</searchLink>. nov/dic2025, Vol. 96 Issue 6, p787-793. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22ACUTE+kidney+failure%22">ACUTE kidney failure</searchLink><br /><searchLink fieldCode="DE" term="%22DIABETIC+nephropathies%22">DIABETIC nephropathies</searchLink><br /><searchLink fieldCode="DE" term="%22CASE-control+method%22">CASE-control method</searchLink><br /><searchLink fieldCode="DE" term="%22DIABETIC+acidosis%22">DIABETIC acidosis</searchLink><br /><searchLink fieldCode="DE" term="%22TYPE+1+diabetes%22">TYPE 1 diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22PEDIATRIC+nephrology%22">PEDIATRIC nephrology</searchLink><br /><searchLink fieldCode="DE" term="%22GLYCOSYLATED+hemoglobin%22">GLYCOSYLATED hemoglobin</searchLink><br /><searchLink fieldCode="DE" term="%22KIDNEY+diseases%22">KIDNEY diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: During diabetic ketoacidosis (DKA), acute kidney injury (AKI) may occur. Objective: To evaluate the association between the presence and severity of AKI during the onset of DKA in patients with type 1 diabetes (T1D) and the development of diabetic kidney disease (DKD). Patients and Method: Case-control study. Patients with T1D who presented with DKA at onset and later developed DKD were identified from a local database. Controls were T1D patients with DKA at onset but without DKD. The presence of AKI at onset was assessed as a factor associated with DKD. Exclusion criteria included missing critical data in medical records, follow-up shorter than 8 years from the onset, kidney disease of a different etiology, and/or initial treatment at a different center. The outcome measure was renal status (presence or absence of DKD) at 8 years after T1D onset. Results: Seventeen cases and 42 controls were studied; 22 patients developed AKI. Cases had higher HbA1c levels from the onset (p = 0.004) and a higher frequency (p = 0.001) and severity (p = 0.012) of AKI during DKA. Only AKI (OR 5.4, 95% CI 1.18-24.6; p = 0.02) remained independently associated with DKD. Conclusion: AKI during the onset of DKA in T1D patients was associated with the development of DKD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Andes Pediatrica is the property of Revista Chilena de Pediatria and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.32641/andespediatr.v96i6.5492 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 787 Subjects: – SubjectFull: ACUTE kidney failure Type: general – SubjectFull: DIABETIC nephropathies Type: general – SubjectFull: CASE-control method Type: general – SubjectFull: DIABETIC acidosis Type: general – SubjectFull: TYPE 1 diabetes Type: general – SubjectFull: PEDIATRIC nephrology Type: general – SubjectFull: GLYCOSYLATED hemoglobin Type: general – SubjectFull: KIDNEY diseases Type: general Titles: – TitleFull: Acute Kidney Injury in children with diabetic ketoacidosis at onset and diabetic kidney disease: a case-control study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mannucci, Carla – PersonEntity: Name: NameFull: Eugenia Andrés, María – PersonEntity: Name: NameFull: Ferraro, Mabel – PersonEntity: Name: NameFull: Balestracci, Alejandro IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: nov/dic2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 24526045 Numbering: – Type: volume Value: 96 – Type: issue Value: 6 Titles: – TitleFull: Andes Pediatrica Type: main |
| ResultId | 1 |
