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The influence of dietary nitrates from plant-based sources on vascular function and hypertension management.

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Title: The influence of dietary nitrates from plant-based sources on vascular function and hypertension management.
Alternate Title: Influencia de los nitratos dietéticos de origen vegetal en la función vascular y el control de la hipertensión.
Authors: Nazokat, Najimova1 rayimjanovanazokat@icloud.com, Bekbaulieva, Gulistan2 gulistanb2006@yahoo.com, Lyalya, Sarkisova3 sarkizovalyalya1234@hmail.com, Mexriban, Baratova4 baratova.mexriban@bsmi.uz, Umar, Turaev5 turaev.umar@bsmi.uz, Akbarova, R. K.6 akbarovaranohon7@gmail.com, Pardayev, Shamedin7 shomidinpardayev@gmail.com, Narzikul, Makhmudov8 narzikul77@gmail.com, Nilufar, Akhmedova4 axmedova.nilufar@bsmi.uz
Source: Revista Latinoamericana de Hipertensión. 2026, Vol. 21 Issue 1, p45-51. 7p.
Subjects: NITRATES, HYPERTENSION, ARTERIAL physiology, PULSE wave analysis, VASODILATORS, BLOOD pressure, PLANT-based diet
Geographic Terms: UZBEKISTAN
Abstract (English): Hypertension is a major public health challenge in Uzbekistan, driving the need for accessible dietary strategies. This study investigated the association between habitual dietary nitrate intake from plant-based sources and vascular health in an Uzbek adult population. In a cross-sectional study of 300 participants (150 hypertensive, 150 normotensive), daily nitrate intake was estimated using a validated food frequency questionnaire tailored to local foods. Vascular outcomes included office blood pressure, flow-mediated dilation (FMD), and carotid- femoral pulse wave velocity (cf-PWV). Median dietary nitrate intake was significantly lower in the hypertensive group compared to the normotensive group (162 mg/ day vs. 215 mg/day, p < 0.001). A strong inverse correlation was observed between nitrate intake and systolic blood pressure (Spearman's rho = -0.41, p < 0.001). In multiple linear regression models adjusted for age, sex, BMI, and smoking, every 50 mg increase in daily nitrate intake was associated with a 4.25 mmHg lower systolic blood pressure (β = -0.29, p < 0.001) and a 0.52% improvement in FMD (β = 0.25, p < 0.001). Participants in the highest tertile of nitrate consumption had significantly better vascular parameters than those in the lowest tertile (p for trend <0.001). [ABSTRACT FROM AUTHOR]
Abstract (Spanish): La hipertensión constituye un importante problema de salud pública en Uzbekistán, lo que impulsa la necesidad de estrategias dietéticas accesibles. Este estudio investigó la asociación entre la ingesta habitual de nitratos de origen vegetal en la dieta y la salud vascular en una población adulta uzbeka. En un estudio transversal con 300 participantes (150 hipertensos y 150 normotensos), se estimó la ingesta diaria de nitratos mediante un cuestionario validado de frecuencia alimentaria adaptado a los alimentos locales. Los resultados vasculares incluyeron la presión arterial en el consultorio, la dilatación mediada por flujo (DMF) y la velocidad de la onda de pulso carótido-femoral (VOPcf). La mediana de la ingesta dietética de nitratos fue significativamente menor en el grupo hipertenso que en el grupo normotenso (162 mg/día frente a 215 mg/día, p < 0,001). Se observó una fuerte correlación inversa entre la ingesta de nitratos y la presión arterial sistólica (rho de Spearman = -0,41, p < 0,001). En modelos de regresión lineal múltiple ajustados por edad, sexo, IMC y tabaquismo, cada aumento de 50 mg en la ingesta diaria de nitratos se asoció con una disminución de 4,25 mmHg en la presión arterial sistólica (β = -0,29, p < 0,001) y una mejora del 0,52 % en la DMF (β = 0,25, p < 0,001). Los participantes en el tercil más alto de consumo de nitratos presentaron parámetros vasculares significativamente mejores que los del tercil más bajo (p para la tendencia < 0,001). [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
Description
Abstract:Hypertension is a major public health challenge in Uzbekistan, driving the need for accessible dietary strategies. This study investigated the association between habitual dietary nitrate intake from plant-based sources and vascular health in an Uzbek adult population. In a cross-sectional study of 300 participants (150 hypertensive, 150 normotensive), daily nitrate intake was estimated using a validated food frequency questionnaire tailored to local foods. Vascular outcomes included office blood pressure, flow-mediated dilation (FMD), and carotid- femoral pulse wave velocity (cf-PWV). Median dietary nitrate intake was significantly lower in the hypertensive group compared to the normotensive group (162 mg/ day vs. 215 mg/day, p < 0.001). A strong inverse correlation was observed between nitrate intake and systolic blood pressure (Spearman's rho = -0.41, p < 0.001). In multiple linear regression models adjusted for age, sex, BMI, and smoking, every 50 mg increase in daily nitrate intake was associated with a 4.25 mmHg lower systolic blood pressure (β = -0.29, p < 0.001) and a 0.52% improvement in FMD (β = 0.25, p < 0.001). Participants in the highest tertile of nitrate consumption had significantly better vascular parameters than those in the lowest tertile (p for trend <0.001). [ABSTRACT FROM AUTHOR]
ISSN:18564550
DOI:10.5281/zenodo.18626418