Más allá de los libros de texto: cilindros vacuolados como marcador emergente en el sedimento urinario.

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Title: Más allá de los libros de texto: cilindros vacuolados como marcador emergente en el sedimento urinario.
Alternate Title: Beyond the Textbooks: Vacuolar Cast as an Emerging Marker in Urinary Sediment.
Authors: Pons-Belda, Oscar D.1 oscardavid.pons@asef.es, Calbet-Tura, Ana1, Livianos-Arias-Camison, Paloma2, Moreno-Noguero, Emilia1, Puig-Hooper, Cassandra E.2
Source: Nefrologia. Mar2026, Vol. 46 Issue 3, p1-2. 2p.
Subjects: DIABETIC nephropathies, PROTEINURIA, KIDNEY cell culture, KIDNEY glomerulus diseases, CHRONIC kidney failure, KIDNEY tubules, URINALYSIS
Abstract (English): The article focuses on vacuolated casts as an emerging marker in urinary sediment, especially in patients with advanced proteinuric glomerulopathies. It presents the case of a woman with diabetic nephropathy who exhibits these casts, characterized by vesicles of variable size and shape without birefringence under polarized light, differentiating them from lipid and hematic casts. Recent studies indicate that the presence of vacuolated casts is associated with nephrotic-range proteinuria and advanced chronic kidney disease, suggesting their possible prognostic value in the progression toward end-stage renal disease. Although their exact origin is unknown, hypotheses have been proposed related to vacuolated renal tubular cells, injured podocytes, or foamy macrophage cells. Precise identification of these casts requires complementary microscopic techniques to avoid diagnostic errors with clinical impact. [Extracted from the article]
Abstract (Spanish): El artículo se centra en los cilindros vacuolados como un marcador emergente en el sedimento urinario, especialmente en pacientes con glomerulopatías proteinúricas avanzadas. Se presenta el caso de una mujer con nefropatía diabética que exhibe estos cilindros, caracterizados por vesículas de tamaño y forma variable sin birrefringencia bajo luz polarizada, diferenciándolos de los cilindros lipídicos y hemáticos. Estudios recientes indican que la presencia de cilindros vacuolados se asocia con proteinuria en rango nefrótico y enfermedad renal crónica avanzada, sugiriendo su posible valor pronóstico en la progresión hacia la enfermedad renal terminal. Aunque su origen exacto es desconocido, se plantean hipótesis relacionadas con células tubulares renales vacuoladas, podocitos lesionados o células espumosas macrofágicas. La identificación precisa de estos cilindros requiere técnicas microscópicas complementarias para evitar errores diagnósticos con impacto clínico. [Extracted from the article]
Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Más allá de los libros de texto: cilindros vacuolados como marcador emergente en el sedimento urinario.
– Name: TitleAlt
  Label: Alternate Title
  Group: TiAlt
  Data: Beyond the Textbooks: Vacuolar Cast as an Emerging Marker in Urinary Sediment.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Pons-Belda%2C+Oscar+D%2E%22">Pons-Belda, Oscar D.</searchLink><relatesTo>1</relatesTo><i> oscardavid.pons@asef.es</i><br /><searchLink fieldCode="AR" term="%22Calbet-Tura%2C+Ana%22">Calbet-Tura, Ana</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Livianos-Arias-Camison%2C+Paloma%22">Livianos-Arias-Camison, Paloma</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Moreno-Noguero%2C+Emilia%22">Moreno-Noguero, Emilia</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Puig-Hooper%2C+Cassandra+E%2E%22">Puig-Hooper, Cassandra E.</searchLink><relatesTo>2</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Nefrologia%22">Nefrologia</searchLink>. Mar2026, Vol. 46 Issue 3, p1-2. 2p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22DIABETIC+nephropathies%22">DIABETIC nephropathies</searchLink><br /><searchLink fieldCode="DE" term="%22PROTEINURIA%22">PROTEINURIA</searchLink><br /><searchLink fieldCode="DE" term="%22KIDNEY+cell+culture%22">KIDNEY cell culture</searchLink><br /><searchLink fieldCode="DE" term="%22KIDNEY+glomerulus+diseases%22">KIDNEY glomerulus diseases</searchLink><br /><searchLink fieldCode="DE" term="%22CHRONIC+kidney+failure%22">CHRONIC kidney failure</searchLink><br /><searchLink fieldCode="DE" term="%22KIDNEY+tubules%22">KIDNEY tubules</searchLink><br /><searchLink fieldCode="DE" term="%22URINALYSIS%22">URINALYSIS</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: The article focuses on vacuolated casts as an emerging marker in urinary sediment, especially in patients with advanced proteinuric glomerulopathies. It presents the case of a woman with diabetic nephropathy who exhibits these casts, characterized by vesicles of variable size and shape without birefringence under polarized light, differentiating them from lipid and hematic casts. Recent studies indicate that the presence of vacuolated casts is associated with nephrotic-range proteinuria and advanced chronic kidney disease, suggesting their possible prognostic value in the progression toward end-stage renal disease. Although their exact origin is unknown, hypotheses have been proposed related to vacuolated renal tubular cells, injured podocytes, or foamy macrophage cells. Precise identification of these casts requires complementary microscopic techniques to avoid diagnostic errors with clinical impact. [Extracted from the article]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: El artículo se centra en los cilindros vacuolados como un marcador emergente en el sedimento urinario, especialmente en pacientes con glomerulopatías proteinúricas avanzadas. Se presenta el caso de una mujer con nefropatía diabética que exhibe estos cilindros, caracterizados por vesículas de tamaño y forma variable sin birrefringencia bajo luz polarizada, diferenciándolos de los cilindros lipídicos y hemáticos. Estudios recientes indican que la presencia de cilindros vacuolados se asocia con proteinuria en rango nefrótico y enfermedad renal crónica avanzada, sugiriendo su posible valor pronóstico en la progresión hacia la enfermedad renal terminal. Aunque su origen exacto es desconocido, se plantean hipótesis relacionadas con células tubulares renales vacuoladas, podocitos lesionados o células espumosas macrofágicas. La identificación precisa de estos cilindros requiere técnicas microscópicas complementarias para evitar errores diagnósticos con impacto clínico. [Extracted from the article]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.nefro.2025.501428
    Languages:
      – Code: spa
        Text: Spanish
    PhysicalDescription:
      Pagination:
        PageCount: 2
        StartPage: 1
    Subjects:
      – SubjectFull: DIABETIC nephropathies
        Type: general
      – SubjectFull: PROTEINURIA
        Type: general
      – SubjectFull: KIDNEY cell culture
        Type: general
      – SubjectFull: KIDNEY glomerulus diseases
        Type: general
      – SubjectFull: CHRONIC kidney failure
        Type: general
      – SubjectFull: KIDNEY tubules
        Type: general
      – SubjectFull: URINALYSIS
        Type: general
    Titles:
      – TitleFull: Más allá de los libros de texto: cilindros vacuolados como marcador emergente en el sedimento urinario.
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            NameFull: Pons-Belda, Oscar D.
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            NameFull: Calbet-Tura, Ana
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            NameFull: Livianos-Arias-Camison, Paloma
      – PersonEntity:
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            NameFull: Moreno-Noguero, Emilia
      – PersonEntity:
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            NameFull: Puig-Hooper, Cassandra E.
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              M: 03
              Text: Mar2026
              Type: published
              Y: 2026
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              Value: 46
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