Global incidence of chlamydia infection and HIV pre-exposure prophylaxis.
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| Title: | Global incidence of chlamydia infection and HIV pre-exposure prophylaxis. |
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| Authors: | Zhou, Xiaoyu1 (AUTHOR), Wan, Liping2 (AUTHOR), Chen, Dandi1 (AUTHOR) cdd13880133906@outlook.com, Huang, Lihua2 (AUTHOR) |
| Source: | AIDS Reviews. Jan-Mar2026, Vol. 28 Issue 1, p21-29. 9p. |
| Subjects: | CHLAMYDIA infections, PRE-exposure prophylaxis, HIV, SEXUALLY transmitted diseases, MEN who have sex with men, EPIDEMIOLOGY, DISEASE incidence |
| Abstract: | AIDS is associated with multiple kinds of sexually transmitted infections, including chlamydia. The global epidemiological status of chlamydia infection in individuals receiving AIDS pre-exposure prophylaxis can provide the crucial information. The researchers performed an updated systematic review and meta-analysis of the case-control studies or observational studies of chlamydia infection incidence in subjects receiving AIDS pre-exposure prophylaxis of the studies after 2018. A total of 24 studies, including 67810 subjects receiving AIDS pre-exposure prophylaxis, were included in the meta-analysis. The pooled incidence of chlamydia infection before receiving AIDS pre-exposure prophylaxis in the whole population of the 24 included studies was 46.9% (p < 0.001). After at least 6 months of pre-exposure prophylaxis, the pooled incidence of chlamydia infection was 51.8% (p < 0.001). For the men who have sex with men subgroup of subjects, the pooled incidence of pre-enrollment and post-pre-exposure prophylaxis was 47.9% and 53.1%, respectively (p < 0.001). Significant heterogeneity might influence the interpretations of the meta-analysis results. Chlamydia infection incidence seems to become higher after the implementation of pre-exposure prophylaxis. In addition, the men who have sex with men subgroup are associated with the higher incidence of chlamydia infection in the pre-enrollment and post-pre-exposure prophylaxis phases. [ABSTRACT FROM AUTHOR] |
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| Database: | MedicLatina |
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| Abstract: | AIDS is associated with multiple kinds of sexually transmitted infections, including chlamydia. The global epidemiological status of chlamydia infection in individuals receiving AIDS pre-exposure prophylaxis can provide the crucial information. The researchers performed an updated systematic review and meta-analysis of the case-control studies or observational studies of chlamydia infection incidence in subjects receiving AIDS pre-exposure prophylaxis of the studies after 2018. A total of 24 studies, including 67810 subjects receiving AIDS pre-exposure prophylaxis, were included in the meta-analysis. The pooled incidence of chlamydia infection before receiving AIDS pre-exposure prophylaxis in the whole population of the 24 included studies was 46.9% (p < 0.001). After at least 6 months of pre-exposure prophylaxis, the pooled incidence of chlamydia infection was 51.8% (p < 0.001). For the men who have sex with men subgroup of subjects, the pooled incidence of pre-enrollment and post-pre-exposure prophylaxis was 47.9% and 53.1%, respectively (p < 0.001). Significant heterogeneity might influence the interpretations of the meta-analysis results. Chlamydia infection incidence seems to become higher after the implementation of pre-exposure prophylaxis. In addition, the men who have sex with men subgroup are associated with the higher incidence of chlamydia infection in the pre-enrollment and post-pre-exposure prophylaxis phases. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 11396121 |
| DOI: | 10.24875/AIDSRev.25000026 |
