The interplay between osteoarthritis and cardiovascular disease: shared pathophysiological mechanisms.

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Title:	The interplay between osteoarthritis and cardiovascular disease: shared pathophysiological mechanisms.
Alternate Title:	La interacción entre la osteoartritis y la enfermedad cardiovascular: mecanismos fisiopatológicos compartidos.
Authors:	Narváez López, Edgar Jonathan¹ jonathanaruto2016@gmail.com, Rocío Arias Mendoza, Lisette del², Chiriboga Condo, Fredy Fabián³, Quizhpi Jiménez, Manuel Antonio⁴, Egas Vásquez, Gabriel Alejandro⁵, Guaman Freire, Michael Alejandro⁶, Calderón Beltrán, Daniel Sebastián⁷, Jaya Larraga, Lorena Paola⁸, Chimborazo Chimborazo, Gloria Alicia^9,10,11, Chimborazo Chimborazo, Jessica Lucía¹²
Source:	Revista Latinoamericana de Hipertensión. 2026, Vol. 21 Issue 2, p86-92. 7p.
Subjects:	OSTEOARTHRITIS, CARDIOVASCULAR diseases, OXIDATIVE stress, INFLAMMATION, ENDOTHELIUM diseases, PATHOLOGICAL physiology, EXTRACELLULAR matrix, ADIPOKINES
Abstract (English):	The relationship between osteoarthritis (OA) and cardiovascular disease (CVD) is complex. Epidemiologically, both OA and CVD have displayed rising trends in the last decades, largely attributed to consistent increases in the prevalence of overlapping risk factors. Furthermore, subjects with OA appear to have a greater cardiovascular risk. As a result, these conditions are associated with a significant burden for public health systems. Both OA and CVD have traditionally been studied as distinct conditions, yet growing epidemiological and molecular evidence suggests these two highly prevalent chronic diseases are linked not merely by shared risk factors such as aging, obesity, and sedentary lifestyle, but also by deeply interconnected biological mechanisms. In ensemble, a plethora of pathophysiologic phenomena, such as chronic inflammation, oxidative stress, adipokine dysregulation, endothelial dysfunction, and extracellular matrix remodeling form a complex and overlapping network of processes that can jointly drive both articular degradation and vascular injury. Bridging the gap between musculoskeletal and cardiovascular research offers the promise of innovative therapies and integrated care strategies that can improve both mobility and longevity for millions of patients worldwide by improving clinical outcomes of both OA and CVD. In this narrative review, we revise the pathophysiological interconnections between OA and CVD. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	La relación entre la osteoartritis (OA) y la enfermedad cardiovascular (ECV) es compleja. Desde el punto de vista epidemiológico, tanto la OA como la ECV han mostrado tendencias crecientes en las últimas décadas, atribuibles en gran medida al aumento sostenido de la prevalencia de factores de riesgo superpuestos. Además, las personas con OA parecen tener un mayor riesgo cardiovascular. Como resultado, estas condiciones se asocian con una carga significativa para los sistemas de salud pública. Tradicionalmente, la OA y la ECV se han estudiado como entidades distintas; sin embargo, la creciente evidencia epidemiológica y molecular sugiere que estas dos enfermedades crónicas, altamente prevalentes, están vinculadas no solo por factores de riesgo compartidos como el envejecimiento, la obesidad y el sedentarismo, sino también por mecanismos biológicos profundamente interconectados. En conjunto, una multitud de fenómenos fisiopatológicos —como la inflamación crónica, el estrés oxidativo, la desregulación de adipocinas, la disfunción endotelial y la remodelación de la matriz extracelular— conforma una red compleja y superpuesta de procesos que pueden impulsar simultáneamente la degradación articular y el daño vascular. Tender puentes entre la investigación musculoesquelética y la cardiovascular ofrece la promesa de terapias innovadoras y estrategias de atención integradas que mejoren tanto la movilidad como la longevidad de millones de pacientes en todo el mundo, al optimizar los resultados clínicos de la OA y la ECV. En esta revisión narrativa, revisamos las interconexiones fisiopatológicas entre la OA y la ECV. [ABSTRACT FROM AUTHOR]
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Database:	MedicLatina

Description
Abstract:	The relationship between osteoarthritis (OA) and cardiovascular disease (CVD) is complex. Epidemiologically, both OA and CVD have displayed rising trends in the last decades, largely attributed to consistent increases in the prevalence of overlapping risk factors. Furthermore, subjects with OA appear to have a greater cardiovascular risk. As a result, these conditions are associated with a significant burden for public health systems. Both OA and CVD have traditionally been studied as distinct conditions, yet growing epidemiological and molecular evidence suggests these two highly prevalent chronic diseases are linked not merely by shared risk factors such as aging, obesity, and sedentary lifestyle, but also by deeply interconnected biological mechanisms. In ensemble, a plethora of pathophysiologic phenomena, such as chronic inflammation, oxidative stress, adipokine dysregulation, endothelial dysfunction, and extracellular matrix remodeling form a complex and overlapping network of processes that can jointly drive both articular degradation and vascular injury. Bridging the gap between musculoskeletal and cardiovascular research offers the promise of innovative therapies and integrated care strategies that can improve both mobility and longevity for millions of patients worldwide by improving clinical outcomes of both OA and CVD. In this narrative review, we revise the pathophysiological interconnections between OA and CVD. [ABSTRACT FROM AUTHOR]
ISSN:	18564550
DOI:	10.5281/zenodo.19151464