The interplay between osteoarthritis and cardiovascular disease: shared pathophysiological mechanisms.
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| Title: | The interplay between osteoarthritis and cardiovascular disease: shared pathophysiological mechanisms. |
|---|---|
| Alternate Title: | La interacción entre la osteoartritis y la enfermedad cardiovascular: mecanismos fisiopatológicos compartidos. |
| Authors: | Narváez López, Edgar Jonathan1 jonathanaruto2016@gmail.com, Rocío Arias Mendoza, Lisette del2, Chiriboga Condo, Fredy Fabián3, Quizhpi Jiménez, Manuel Antonio4, Egas Vásquez, Gabriel Alejandro5, Guaman Freire, Michael Alejandro6, Calderón Beltrán, Daniel Sebastián7, Jaya Larraga, Lorena Paola8, Chimborazo Chimborazo, Gloria Alicia9,10,11, Chimborazo Chimborazo, Jessica Lucía12 |
| Source: | Revista Latinoamericana de Hipertensión. 2026, Vol. 21 Issue 2, p86-92. 7p. |
| Subjects: | OSTEOARTHRITIS, CARDIOVASCULAR diseases, OXIDATIVE stress, INFLAMMATION, ENDOTHELIUM diseases, PATHOLOGICAL physiology, EXTRACELLULAR matrix, ADIPOKINES |
| Abstract (English): | The relationship between osteoarthritis (OA) and cardiovascular disease (CVD) is complex. Epidemiologically, both OA and CVD have displayed rising trends in the last decades, largely attributed to consistent increases in the prevalence of overlapping risk factors. Furthermore, subjects with OA appear to have a greater cardiovascular risk. As a result, these conditions are associated with a significant burden for public health systems. Both OA and CVD have traditionally been studied as distinct conditions, yet growing epidemiological and molecular evidence suggests these two highly prevalent chronic diseases are linked not merely by shared risk factors such as aging, obesity, and sedentary lifestyle, but also by deeply interconnected biological mechanisms. In ensemble, a plethora of pathophysiologic phenomena, such as chronic inflammation, oxidative stress, adipokine dysregulation, endothelial dysfunction, and extracellular matrix remodeling form a complex and overlapping network of processes that can jointly drive both articular degradation and vascular injury. Bridging the gap between musculoskeletal and cardiovascular research offers the promise of innovative therapies and integrated care strategies that can improve both mobility and longevity for millions of patients worldwide by improving clinical outcomes of both OA and CVD. In this narrative review, we revise the pathophysiological interconnections between OA and CVD. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | La relación entre la osteoartritis (OA) y la enfermedad cardiovascular (ECV) es compleja. Desde el punto de vista epidemiológico, tanto la OA como la ECV han mostrado tendencias crecientes en las últimas décadas, atribuibles en gran medida al aumento sostenido de la prevalencia de factores de riesgo superpuestos. Además, las personas con OA parecen tener un mayor riesgo cardiovascular. Como resultado, estas condiciones se asocian con una carga significativa para los sistemas de salud pública. Tradicionalmente, la OA y la ECV se han estudiado como entidades distintas; sin embargo, la creciente evidencia epidemiológica y molecular sugiere que estas dos enfermedades crónicas, altamente prevalentes, están vinculadas no solo por factores de riesgo compartidos como el envejecimiento, la obesidad y el sedentarismo, sino también por mecanismos biológicos profundamente interconectados. En conjunto, una multitud de fenómenos fisiopatológicos —como la inflamación crónica, el estrés oxidativo, la desregulación de adipocinas, la disfunción endotelial y la remodelación de la matriz extracelular— conforma una red compleja y superpuesta de procesos que pueden impulsar simultáneamente la degradación articular y el daño vascular. Tender puentes entre la investigación musculoesquelética y la cardiovascular ofrece la promesa de terapias innovadoras y estrategias de atención integradas que mejoren tanto la movilidad como la longevidad de millones de pacientes en todo el mundo, al optimizar los resultados clínicos de la OA y la ECV. En esta revisión narrativa, revisamos las interconexiones fisiopatológicas entre la OA y la ECV. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista Latinoamericana de Hipertensión is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 192704270 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The interplay between osteoarthritis and cardiovascular disease: shared pathophysiological mechanisms. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: La interacción entre la osteoartritis y la enfermedad cardiovascular: mecanismos fisiopatológicos compartidos. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Narváez+López%2C+Edgar+Jonathan%22">Narváez López, Edgar Jonathan</searchLink><relatesTo>1</relatesTo><i> jonathanaruto2016@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Rocío+Arias+Mendoza%2C+Lisette+del%22">Rocío Arias Mendoza, Lisette del</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Chiriboga+Condo%2C+Fredy+Fabián%22">Chiriboga Condo, Fredy Fabián</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Quizhpi+Jiménez%2C+Manuel+Antonio%22">Quizhpi Jiménez, Manuel Antonio</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Egas+Vásquez%2C+Gabriel+Alejandro%22">Egas Vásquez, Gabriel Alejandro</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Guaman+Freire%2C+Michael+Alejandro%22">Guaman Freire, Michael Alejandro</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Calderón+Beltrán%2C+Daniel+Sebastián%22">Calderón Beltrán, Daniel Sebastián</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Jaya+Larraga%2C+Lorena+Paola%22">Jaya Larraga, Lorena Paola</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Chimborazo+Chimborazo%2C+Gloria+Alicia%22">Chimborazo Chimborazo, Gloria Alicia</searchLink><relatesTo>9,10,11</relatesTo><br /><searchLink fieldCode="AR" term="%22Chimborazo+Chimborazo%2C+Jessica+Lucía%22">Chimborazo Chimborazo, Jessica Lucía</searchLink><relatesTo>12</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+Latinoamericana+de+Hipertensión%22">Revista Latinoamericana de Hipertensión</searchLink>. 2026, Vol. 21 Issue 2, p86-92. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22OSTEOARTHRITIS%22">OSTEOARTHRITIS</searchLink><br /><searchLink fieldCode="DE" term="%22CARDIOVASCULAR+diseases%22">CARDIOVASCULAR diseases</searchLink><br /><searchLink fieldCode="DE" term="%22OXIDATIVE+stress%22">OXIDATIVE stress</searchLink><br /><searchLink fieldCode="DE" term="%22INFLAMMATION%22">INFLAMMATION</searchLink><br /><searchLink fieldCode="DE" term="%22ENDOTHELIUM+diseases%22">ENDOTHELIUM diseases</searchLink><br /><searchLink fieldCode="DE" term="%22PATHOLOGICAL+physiology%22">PATHOLOGICAL physiology</searchLink><br /><searchLink fieldCode="DE" term="%22EXTRACELLULAR+matrix%22">EXTRACELLULAR matrix</searchLink><br /><searchLink fieldCode="DE" term="%22ADIPOKINES%22">ADIPOKINES</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: The relationship between osteoarthritis (OA) and cardiovascular disease (CVD) is complex. Epidemiologically, both OA and CVD have displayed rising trends in the last decades, largely attributed to consistent increases in the prevalence of overlapping risk factors. Furthermore, subjects with OA appear to have a greater cardiovascular risk. As a result, these conditions are associated with a significant burden for public health systems. Both OA and CVD have traditionally been studied as distinct conditions, yet growing epidemiological and molecular evidence suggests these two highly prevalent chronic diseases are linked not merely by shared risk factors such as aging, obesity, and sedentary lifestyle, but also by deeply interconnected biological mechanisms. In ensemble, a plethora of pathophysiologic phenomena, such as chronic inflammation, oxidative stress, adipokine dysregulation, endothelial dysfunction, and extracellular matrix remodeling form a complex and overlapping network of processes that can jointly drive both articular degradation and vascular injury. Bridging the gap between musculoskeletal and cardiovascular research offers the promise of innovative therapies and integrated care strategies that can improve both mobility and longevity for millions of patients worldwide by improving clinical outcomes of both OA and CVD. In this narrative review, we revise the pathophysiological interconnections between OA and CVD. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: La relación entre la osteoartritis (OA) y la enfermedad cardiovascular (ECV) es compleja. Desde el punto de vista epidemiológico, tanto la OA como la ECV han mostrado tendencias crecientes en las últimas décadas, atribuibles en gran medida al aumento sostenido de la prevalencia de factores de riesgo superpuestos. Además, las personas con OA parecen tener un mayor riesgo cardiovascular. Como resultado, estas condiciones se asocian con una carga significativa para los sistemas de salud pública. Tradicionalmente, la OA y la ECV se han estudiado como entidades distintas; sin embargo, la creciente evidencia epidemiológica y molecular sugiere que estas dos enfermedades crónicas, altamente prevalentes, están vinculadas no solo por factores de riesgo compartidos como el envejecimiento, la obesidad y el sedentarismo, sino también por mecanismos biológicos profundamente interconectados. En conjunto, una multitud de fenómenos fisiopatológicos —como la inflamación crónica, el estrés oxidativo, la desregulación de adipocinas, la disfunción endotelial y la remodelación de la matriz extracelular— conforma una red compleja y superpuesta de procesos que pueden impulsar simultáneamente la degradación articular y el daño vascular. Tender puentes entre la investigación musculoesquelética y la cardiovascular ofrece la promesa de terapias innovadoras y estrategias de atención integradas que mejoren tanto la movilidad como la longevidad de millones de pacientes en todo el mundo, al optimizar los resultados clínicos de la OA y la ECV. En esta revisión narrativa, revisamos las interconexiones fisiopatológicas entre la OA y la ECV. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista Latinoamericana de Hipertensión is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=192704270 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.5281/zenodo.19151464 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 86 Subjects: – SubjectFull: OSTEOARTHRITIS Type: general – SubjectFull: CARDIOVASCULAR diseases Type: general – SubjectFull: OXIDATIVE stress Type: general – SubjectFull: INFLAMMATION Type: general – SubjectFull: ENDOTHELIUM diseases Type: general – SubjectFull: PATHOLOGICAL physiology Type: general – SubjectFull: EXTRACELLULAR matrix Type: general – SubjectFull: ADIPOKINES Type: general Titles: – TitleFull: The interplay between osteoarthritis and cardiovascular disease: shared pathophysiological mechanisms. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Narváez López, Edgar Jonathan – PersonEntity: Name: NameFull: Rocío Arias Mendoza, Lisette del – PersonEntity: Name: NameFull: Chiriboga Condo, Fredy Fabián – PersonEntity: Name: NameFull: Quizhpi Jiménez, Manuel Antonio – PersonEntity: Name: NameFull: Egas Vásquez, Gabriel Alejandro – PersonEntity: Name: NameFull: Guaman Freire, Michael Alejandro – PersonEntity: Name: NameFull: Calderón Beltrán, Daniel Sebastián – PersonEntity: Name: NameFull: Jaya Larraga, Lorena Paola – PersonEntity: Name: NameFull: Chimborazo Chimborazo, Gloria Alicia – PersonEntity: Name: NameFull: Chimborazo Chimborazo, Jessica Lucía IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: 2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 18564550 Numbering: – Type: volume Value: 21 – Type: issue Value: 2 Titles: – TitleFull: Revista Latinoamericana de Hipertensión Type: main |
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