Secreción autónoma leve de cortisol: comorbilidades y resultados del tratamiento quirúrgico.
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| Title: | Secreción autónoma leve de cortisol: comorbilidades y resultados del tratamiento quirúrgico. |
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| Alternate Title: | Mild autonomic cortisol secretion: comorbidities and surgical treatment outcomes. |
| Authors: | Capalbo, M. Soledad1 (AUTHOR) soledad.capalbo@hotmail.com, Deligiannis, Natalia1 (AUTHOR), Danilowicz, Karina1 (AUTHOR) |
| Source: | Medicina (Buenos Aires). nov/dic2025, Vol. 85 Issue 6, p1326-1336. 11p. |
| Subjects: | COMORBIDITY, ADRENAL tumors, HYPERTENSION, CLINICAL biochemistry, HYDROCORTISONE, CUSHING'S syndrome, DIABETES |
| Abstract (English): | "Mild autonomous cortisol secretion" is present in up to one-third of patients with adrenal incidentalomas and is characterized by excessive cortisol production without the typical clinical signs of Cushing's syndrome. Due to the lack of typical symptoms, biochemical evaluation is essential for diagnosis, as chronic cortisol secretion has been linked to multiple comorbidities (hypertension, diabetes, metabolic syndrome, dyslipidemia and osteo porosis) as well as increased mortality. While numerous studies address the comorbidities associated with auton omous cortisol secretion and its clinical impact, the indi cation for surgery remains uncertain and controversial; currently, no guidelines provide precise recommendations for surgical treatment in these patients. However, the few studies reported in the literature suggest an improvement in the cardiometabolic profile after adrenalectomy. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | La "secreción autónoma leve de cortisol" está pre sente en hasta un tercio de los pacientes con inciden talomas adrenales y se caracteriza por una producción excesiva de cortisol sin los signos clínicos típicos del síndrome de Cushing. Debido a la falta de sintomato logía típica, la evaluación bioquímica es fundamental para establecer el diagnóstico ya que la secreción cró nica de cortisol ha sido vinculada a múltiples comor bilidades (hipertensión arterial, diabetes, síndrome metabólico, dislipemia, y osteoporosis), así como a una mayor mortalidad. Si bien existen numerosos es tudios que abordan las comorbilidades asociadas con la secreción autónoma de cortisol y su impacto clínico, la indicación de cirugía es incierta y controvertida; actualmente ninguna guía establece recomendaciones precisas de tratamiento quirúrgico en estos pacientes. Sin embargo, los pocos estudios reportados en la lite ratura apuntan a una mejoría en el perfil cardiometa bólico luego de la adrenalectomía. [ABSTRACT FROM AUTHOR] |
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| Database: | MedicLatina |
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| Abstract: | "Mild autonomous cortisol secretion" is present in up to one-third of patients with adrenal incidentalomas and is characterized by excessive cortisol production without the typical clinical signs of Cushing's syndrome. Due to the lack of typical symptoms, biochemical evaluation is essential for diagnosis, as chronic cortisol secretion has been linked to multiple comorbidities (hypertension, diabetes, metabolic syndrome, dyslipidemia and osteo porosis) as well as increased mortality. While numerous studies address the comorbidities associated with auton omous cortisol secretion and its clinical impact, the indi cation for surgery remains uncertain and controversial; currently, no guidelines provide precise recommendations for surgical treatment in these patients. However, the few studies reported in the literature suggest an improvement in the cardiometabolic profile after adrenalectomy. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00257680 |
