Clinical features, echocardiographic findings and surgical aspects related to mortality in complicated endocarditis.

Saved in:
Bibliographic Details
Title: Clinical features, echocardiographic findings and surgical aspects related to mortality in complicated endocarditis.
Alternate Title: Características clínicas, hallazgos ecocardiográficos y aspectos quirúrgicos relacionados con la mortalidad en endocarditis infecciosa complicada.
Authors: Bazo-Medina, Jessica Mariel1 mariel.mb@outlook.com, Castaño-Guerra, Rodolfo de Jesus1
Source: Cardiovascular & Metabolic Science. Jan-Mar2026, Vol. 37 Issue 1, p9-20. 12p.
Subjects: MORTALITY risk factors, SURGICAL complications, ECHOCARDIOGRAPHY, SYMPTOMS, INFECTIVE endocarditis, TYPE 2 diabetes, HEART failure, TREATMENT effectiveness
Geographic Terms: MEXICO
Abstract (English): Infective Endocarditis is a serious public health problem with high morbidity and mortality, and a considerable prevalence in our setting. International guidelines for the diagnosis and treatment of endocarditis consider clinical, laboratory, and imaging criteria to define this entity and establish recommendations for its management. Global mortality is estimated around 20%; however, there is no information available on the epidemiology or prognosis in Mexico. An important finding among patients at our centre is the incidence of cases with local complications. Naturally, as anatomical complexity increases, surgery becomes more challenging, so local complications are expected to directly influence the risk of perioperative death. The purpose of this study was to identify risk factors associated with echocardiographic complications in patients diagnosed with Infective Endocarditis (IE) at tertiary level public hospital, as well as to evaluate their postoperative outcome. This information could contribute to a better understanding of IE and facilitate more timely treatment. Over a five-year period, 60 patients were included, with an incidence of local complications of 73.3%. No variables were significantly associated with the development of local complications. However, type 2 diabetes (p = 0.03), heart failure (p = 0.01), and prosthetic valves (p = 0.03) were risk factors associated with mortality. Regarding clinical scenario, uncontrolled sepsis (p = 0.02), septic shock (p = 0.01) and multiple organ failure (p = 0.001) at the time of IE diagnosis and after surgery, had higher mortality (p = 0.02). [ABSTRACT FROM AUTHOR]
Abstract (Spanish): La endocarditis infecciosa es un grave problema de salud pública con alta morbilidad, mortalidad y una prevalencia considerable en nuestro país. Las guías internacionales para el diagnóstico y tratamiento de la endocarditis consideran criterios clínicos, de laboratorio e imagenológicos que definen esta entidad y establecen recomendaciones para el algoritmo de estudio. Globalmente la mortalidad se estima en torno al 20%; sin embargo, no se dispone de información sobre la epidemiología ni el pronóstico en México. Un hallazgo importante en los pacientes de nuestro centro es la incidencia de casos con complicaciones locales. Naturalmente, cuanto más compleja es una lesión, más retadora puede tornarse la cirugía, por lo que se espera que las complicaciones locales influyan directamente el riesgo de muerte perioperatoria. El propósito de este estudio fue identificar los factores de riesgo asociados con complicaciones ecocardiográficas en pacientes con diagnóstico de Endocarditis Infecciosa (EI) en un hospital público de tercer nivel, así como evaluar su pronóstico postoperatorio. Esta información podría contribuir al mejor entendimiento de la EI y favorecer un tratamiento más oportuno. Se incluyeron sesenta pacientes durante un período de cinco años, con una incidencia de complicaciones locales del 73.3%. Ninguna de las variables evaluadas se asoció significativamente al desarrollo de complicaciones locales. Mientras que la diabetes tipo 2 (p = 0.03), la insuficiencia cardíaca (p = 0.01) y las prótesis valvulares (p = 0.03) fueron factores de riesgo asociados con la mortalidad. En cuanto al contexto clínico, la sepsis no controlada (p = 0.02), el choque séptico (p = 0.01), así como la falla multiorgánica (p = 0.001) en el momento del diagnóstico de EI (p = 0.001) y después de la cirugía se asociaron con una mayor mortalidad (p = 0.02). [ABSTRACT FROM AUTHOR]
Copyright of Cardiovascular & Metabolic Science is the property of Cardiovascular & Metabolic Science, Asociacion Nacional de Cardiologos de Mexico A.C. (ANCAM) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
Description
Abstract:Infective Endocarditis is a serious public health problem with high morbidity and mortality, and a considerable prevalence in our setting. International guidelines for the diagnosis and treatment of endocarditis consider clinical, laboratory, and imaging criteria to define this entity and establish recommendations for its management. Global mortality is estimated around 20%; however, there is no information available on the epidemiology or prognosis in Mexico. An important finding among patients at our centre is the incidence of cases with local complications. Naturally, as anatomical complexity increases, surgery becomes more challenging, so local complications are expected to directly influence the risk of perioperative death. The purpose of this study was to identify risk factors associated with echocardiographic complications in patients diagnosed with Infective Endocarditis (IE) at tertiary level public hospital, as well as to evaluate their postoperative outcome. This information could contribute to a better understanding of IE and facilitate more timely treatment. Over a five-year period, 60 patients were included, with an incidence of local complications of 73.3%. No variables were significantly associated with the development of local complications. However, type 2 diabetes (p = 0.03), heart failure (p = 0.01), and prosthetic valves (p = 0.03) were risk factors associated with mortality. Regarding clinical scenario, uncontrolled sepsis (p = 0.02), septic shock (p = 0.01) and multiple organ failure (p = 0.001) at the time of IE diagnosis and after surgery, had higher mortality (p = 0.02). [ABSTRACT FROM AUTHOR]
ISSN:26832828
DOI:10.35366/122889