Bibliographic Details
| Title: |
Avances en nanosistemas para liberación controlada en odontología: clasificación y aplicaciones terapeúticas. |
| Alternate Title: |
Advances in nanosystems for controlled drug delivery in dentistry: classification and therapeutic applications. |
| Authors: |
Maldonado-Villamizar, Johana1 johanamaria.mv@gmail.com |
| Source: |
Revista Kiru. ene-mar2026, Vol. 23 Issue 1, p61-75. 15p. |
| Subjects: |
DRUG delivery systems, DENTISTRY, LIPOSOMES, NANOSCIENCE, TREATMENT effectiveness, POLYMERIC drug delivery systems, NANOMEDICINE |
| Abstract (English): |
Nanomedicine has transformed drug delivery through the development of nanosystems capable of releasing therapeutic agents in a controlled manner. This article reviews the classification of nanosystems based on their composition (lipid-based, polymeric, inorganic, and biomolecule derived) focusing on their structure, synthesis process, and dental applications. Compared to conventional therapies, nanosystems offer advantages such as enhanced tissue penetration, optimized pharmacokinetics, and reduced toxicity. A literature review was conducted using scientific publications from 2010 to June 2025, including original studies and systematic reviews retrieved from PubMed, Cochrane Library, and Scopus. The findings demonstrate that nanosystems present a promising alternative for improving bioavailability and enabling precise therapeutic targeting across various tissues, with significant potential for oral cavity applications. In conclusion, while nanosystems represent a promising platform to advance the efficacy and safety of clinical treatments, challenges related to scalability and long-term toxicity remain. These issues represent critical barriers that must be addressed to enable their integration into real-world clinical settings. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
La nanomedicina ha revolucionado la administración de fármacos mediante el desarrollo de nanosistemas capaces de liberar agentes terapéuticos de manera controlada. Este artículo revisa la clasificación de los nanosistemas según su composición (lipídicos, poliméricos, inorgánicos y basados en biomoléculas) centrándose en su estructura, proceso de síntesis y sus aplicaciones odontológicas. Comparados con terapéuticas convencionales, los nanosistemas ofrecen ventajas como una mejor penetración tisular, optimización farmacocinética y reducción de la toxicidad. Se realizó una revisión bibliográfica de literatura científica publicada entre 2010 y junio de 2025, que incluyó estudios originales y revisiones sistemáticas extraídas de PubMed, Cochrane Library y Scopus. Los hallazgos demuestran que los nanosistemas presentan una alternativa prometedora para mejorar la biodisponibilidad y focalización terapéutica precisa en diferentes tejidos, con aplicaciones prometedoras en la cavidad bucal. En conclusión, aunque los nanosistemas representan una plataforma prometedora para avanzar en la eficacia y seguridad de tratamientos clínicos, persiste el desafío de la escalabilidad y la toxicidad a largo plazo. Estos aspectos representan barreras críticas que deben abordarse para facilitar su adopción en entornos clínicos reales. [ABSTRACT FROM AUTHOR] |
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| Database: |
MedicLatina |
