Desvelando el vínculo entre microorganismos y glioma: un protocolo de revisión de alcance.

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Bibliographic Details
Title: Desvelando el vínculo entre microorganismos y glioma: un protocolo de revisión de alcance.
Alternate Title: Unraveling the link between microorganisms and glioma: a scoping review protocol.
Authors: Estêvão, M. Dulce1,2 mestevao@ualg.pt, Perez-Neri, Iván3, Teotónio-Fernandes, Mónica1,2
Source: Archivos de Neurociencias. ene-mar2026, Vol. 31 Issue 1, p23-28. 6p.
Subjects: GLIOMAS, SYSTEMATIC reviews, ONCOGENES, GENETICS
Abstract (English): Glioblastomas, highly malignant primary brain tumors, comprise ~50% of gliomas. Knowledge on their prevention, early detection, and treatment is scarce, making understanding their etiology and therapy resistance crucial. Recent evidence controversially suggests a link between brain microorganisms and cancer development. This protocol outlines a systematic scoping review to identify microorganism species associated with gliomas, potential pathogenetic mechanisms, and analytical procedures employed. Studies will be retrieved from Web of Science, MEDLINE/PubMed, Scopus, and Google Scholar. We will include studies reporting on diagnosed gliomas, microorganism presence in tumors, oncogenic mechanisms (any model), and analyses of biopsies/resected tumors. Exclusions include other brain tumors/body fluids, therapeutic microorganism use, non-original research, articles not in English/Spanish/Portuguese if untranslatable, and irretrievable full texts. A narrative summary will synthesize available data. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Los glioblastomas, tumores cerebrales primarios altamente malignos, constituyen ~50% de los gliomas. El conocimiento sobre su prevención, detección temprana y tratamiento es escaso, y es crucial la comprensión de sus causas y resistencia a la terapia. Evidencia reciente sugiere de forma controvertida un vínculo entre los microorganismos cerebrales y el desarrollo del cáncer. Este protocolo describe una revisión sistemática de alcance (scoping review) para identificar especies de microorganismos asociadas con gliomas, posibles mecanismos patogénicos y los procedimientos analíticos empleados. Los estudios se recuperarán de Web of Science, Medline/PubMed, Scopus y Google Scholar. Se incluirán estudios que reporten sobre gliomas diagnosticados, presencia de microorganismos en tumores, mecanismos oncogénicos (cualquier modelo) y análisis de biopsias/tumores resecados. Las exclusiones incluyen otros tumores cerebrales/fluidos corporales, uso terapéutico de microorganismos, investigación no original, artículos no escritos en inglés/español/portugués que no puedan traducirse adecuadamente y textos completos irrecuperables. Un resumen narrativo sintetizará los datos disponibles. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
Description
Abstract:Glioblastomas, highly malignant primary brain tumors, comprise ~50% of gliomas. Knowledge on their prevention, early detection, and treatment is scarce, making understanding their etiology and therapy resistance crucial. Recent evidence controversially suggests a link between brain microorganisms and cancer development. This protocol outlines a systematic scoping review to identify microorganism species associated with gliomas, potential pathogenetic mechanisms, and analytical procedures employed. Studies will be retrieved from Web of Science, MEDLINE/PubMed, Scopus, and Google Scholar. We will include studies reporting on diagnosed gliomas, microorganism presence in tumors, oncogenic mechanisms (any model), and analyses of biopsies/resected tumors. Exclusions include other brain tumors/body fluids, therapeutic microorganism use, non-original research, articles not in English/Spanish/Portuguese if untranslatable, and irretrievable full texts. A narrative summary will synthesize available data. [ABSTRACT FROM AUTHOR]
ISSN:10285938
DOI:10.24875/ANC.M25000043