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Epigenetic clocks and biological aging acceleration in early-onset hypertension.

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Title: Epigenetic clocks and biological aging acceleration in early-onset hypertension.
Alternate Title: Relojes epigenéticos y aceleración del envejecimiento biológico en la hipertensión de inicio temprano.
Authors: Axrorov, Alisher1 alishersh554@gmail.com, Sharipova, Elvina2 elvinka85@mail.ru, Xamidov, Nodirbek3 hamidovn460@gmail.com, Yunusov, Dilshod4 sheyx1996@gmail.com, Ikramova, Nodira5 ikromovanodira00@gmail.com, Salomov, G'ulom6 gulom_salomov@tues.uz, Furkatjon, Anvarov7 anvarovfurqatjon@gmail.com
Source: Revista Latinoamericana de Hipertensión. 2026, Vol. 21 Issue 3, p137-144. 8p.
Subjects: BLOOD pressure, DNA methylation, PREHYPERTENSION, CELLULAR aging, INFLAMMATORY mediators, CHRONOBIOLOGY
Abstract (English): People who develop high blood pressure before turning 50 years old face increased risk of severe heart problems compared to others. Scientists developed epigenetic clocks as advanced methods to determine biological age and study aging processes. The research project employed a case-control design to examine how accelerated epigenetic aging affects premature hypertension development among Uzbek study participants. The research study enrolled 80 participants who had premature hypertension and 80 participants with matching age and sex who did not have health problems. The researchers used five epigenetic clocks to establish epigenetic age through Horvath, Hannum, PhenoAge, GrimAge, and SkinBloodClock analysis of DNA methylation data from peripheral blood leukocytes. The study found that all epigenetic clocks measured higher epigenetic age in patients compared to the control group. The biggest difference between the two groups appeared on the GrimAge clock, which assessed patients as 7.4 years older their actual age, while the control group showed no age difference. The patients who experienced systolic blood pressure measurements above 160 mmHg showed greater disease progression than those with lower blood pressure standards. The research showed that every year of GrimAge aging acceleration raised the risk of premature hypertension development by 38 percent (OR = 1.48). The study found that accelerated aging showed a strong positive relationship with C-reactive protein and interleukin-6, while people who exercised regularly had lower levels of these proteins. The research results demonstrate that early onset hypertension leads to faster epigenetic aging process which occurs at different rates depending on the patient's level of disease progression and body temperature and the time when they first showed symptoms. Epigenetic age assessment provides a new method to evaluate patient risk and disease outcome in this population. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Las personas que desarrollan hipertensión arterial antes de los 50 años tienen un mayor riesgo de sufrir problemas cardíacos graves en comparación con otras personas. Un grupo de científicos desarrolló relojes epigenéticos como métodos avanzados para determinar la edad biológica y estudiar los procesos de envejecimiento. El proyecto de investigación empleó un diseño de casos y controles para examinar cómo el envejecimiento epigenético acelerado afecta el desarrollo de hipertensión prematura entre los participantes uzbekos del estudio. El estudio incluyó a 80 participantes con hipertensión prematura y 80 participantes de la misma edad y sexo que no presentaban problemas de salud. Los investigadores utilizaron cinco relojes epigenéticos para establecer la edad epigenética mediante el análisis de datos de metilación del ADN de leucocitos de sangre periférica mediante Horvath, Hannum, PhenoAge, GrimAge y SkinBloodClock. El estudio reveló que todos los relojes epigenéticos midieron una edad epigenética más alta en los pacientes en comparación con el grupo control. La mayor diferencia entre los dos grupos se observó en el reloj GrimAge, que evaluó a los pacientes como 7,4 años mayores que su edad real, mientras que el grupo control no mostró diferencia de edad. Los pacientes con presión arterial sistólica superior a 160 mmHg mostraron una mayor progresión de la enfermedad que aquellos con niveles de presión arterial más bajos. La investigación demostró que cada año de aceleración del envejecimiento con GrimAge aumentaba el riesgo de desarrollar hipertensión prematura en un 38 % (OR = 1,48). El estudio descubrió que el envejecimiento acelerado mostró una fuerte relación positiva con la proteína C reactiva y la interleucina-6, mientras que las personas que hacían ejercicio regularmente presentaban niveles más bajos de estas proteínas. Los resultados de la investigación demuestran que la hipertensión de inicio temprano conduce a un proceso de envejecimiento epigenético más rápido, que ocurre a diferentes ritmos según el nivel de progresión de la enfermedad, la temperatura corporal y el momento en que aparecieron los primeros síntomas. La evaluación de la edad epigenética proporciona un nuevo método para evaluar el riesgo del paciente y el pronóstico de la enfermedad en esta población. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
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Abstract:People who develop high blood pressure before turning 50 years old face increased risk of severe heart problems compared to others. Scientists developed epigenetic clocks as advanced methods to determine biological age and study aging processes. The research project employed a case-control design to examine how accelerated epigenetic aging affects premature hypertension development among Uzbek study participants. The research study enrolled 80 participants who had premature hypertension and 80 participants with matching age and sex who did not have health problems. The researchers used five epigenetic clocks to establish epigenetic age through Horvath, Hannum, PhenoAge, GrimAge, and SkinBloodClock analysis of DNA methylation data from peripheral blood leukocytes. The study found that all epigenetic clocks measured higher epigenetic age in patients compared to the control group. The biggest difference between the two groups appeared on the GrimAge clock, which assessed patients as 7.4 years older their actual age, while the control group showed no age difference. The patients who experienced systolic blood pressure measurements above 160 mmHg showed greater disease progression than those with lower blood pressure standards. The research showed that every year of GrimAge aging acceleration raised the risk of premature hypertension development by 38 percent (OR = 1.48). The study found that accelerated aging showed a strong positive relationship with C-reactive protein and interleukin-6, while people who exercised regularly had lower levels of these proteins. The research results demonstrate that early onset hypertension leads to faster epigenetic aging process which occurs at different rates depending on the patient's level of disease progression and body temperature and the time when they first showed symptoms. Epigenetic age assessment provides a new method to evaluate patient risk and disease outcome in this population. [ABSTRACT FROM AUTHOR]
ISSN:18564550
DOI:10.5281/zenodo.19050450