Adenocarcinoma de recto con células en anillo de sello: implicancias diagnósticas y terapéuticas. Reporte de un caso.

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Title: Adenocarcinoma de recto con células en anillo de sello: implicancias diagnósticas y terapéuticas. Reporte de un caso.
Alternate Title: Rectal adenocarcinoma with signet ring cells: diagnostic and therapeutic implications. A case report.
Authors: Remezal-Serrano, Beatriz1 dra.remezal@gmail.com, Tomás-Martínez, Ana1, Rodríguez-Martínez, Eduardo1
Source: Revista de Cirugia. 2026, Vol. 78 Issue 3, p322-325. 4p.
Abstract (English): Introduction: Rectal signet ring cell adenocarcinoma is a rare histological subtype of colorectal cancer, characterized by aggressive biological behavior and an unfavorable prognosis compared to conventional adenocarcinoma. Case report: We report the case of a 49-year-old man diagnosed with rectal signet ring cell adenocarcinoma after presenting with rectal symptoms. Colonoscopy revealed a circumferential lesion in the lower rectum, and the diagnosis was confirmed by endoscopic biopsy. Pelvic magnetic resonance imaging and computed tomography allowed clinical staging of a locally advanced tumor. The case was discussed at a multidisciplinary tumor board, and a multimodal treatment approach was adopted, including induction chemotherapy followed by long-course chemoradiotherapy and curative-intent surgery. Histopathological analysis of the surgical specimen confirmed the diagnosis and allowed definitive pathological staging. Conclusion: This case highlights the aggressive biological behavior of rectal signet ring cell adenocarcinoma and underscores the importance of accurate diagnosis and a multidisciplinary management approach to optimize oncological outcomes in this rare histological variant. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción: El adenocarcinoma de recto con células en anillo de sello es un subtipo histológico poco frecuente del cáncer colorrectal, caracterizado por un comportamiento: biológico agresivo y un pronóstico desfavorable en comparación con las variantes clásicas de adenocarcinoma. Caso clínico: Se presenta el caso de un varón de 49 años diagnosticado de adenocarcinoma de recto con células en anillo de sello tras consultar por síndrome rectal. La colonoscopia evidenció una lesión rectal circunferencial en el recto bajo, confirmándose el diagnóstico mediante biopsia endoscópica. El estudio de extensión mediante resonancia magnética pélvica y tomografía computarizada permitió establecer una estadificación clínica localmente avanzada. El caso fue evaluado en comité multidisciplinar, decidiéndose un tratamiento multimodal con quimioterapia de inducción seguida de radioquimioterapia de curso largo y cirugía con intención curativa. El análisis anatomopatológico de la pieza quirúrgica confirmó el diagnóstico y permitió establecer la estadificación patológica definitiva. Conclusión: Este caso pone de manifiesto la agresividad biológica del adenocarcinoma rectal con células en anillo de sello y la importancia de un abordaje diagnóstico preciso y un manejo multidisciplinar para optimizar los resultados oncológicos en esta variante histológica infrecuente. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
Description
Abstract:Introduction: Rectal signet ring cell adenocarcinoma is a rare histological subtype of colorectal cancer, characterized by aggressive biological behavior and an unfavorable prognosis compared to conventional adenocarcinoma. Case report: We report the case of a 49-year-old man diagnosed with rectal signet ring cell adenocarcinoma after presenting with rectal symptoms. Colonoscopy revealed a circumferential lesion in the lower rectum, and the diagnosis was confirmed by endoscopic biopsy. Pelvic magnetic resonance imaging and computed tomography allowed clinical staging of a locally advanced tumor. The case was discussed at a multidisciplinary tumor board, and a multimodal treatment approach was adopted, including induction chemotherapy followed by long-course chemoradiotherapy and curative-intent surgery. Histopathological analysis of the surgical specimen confirmed the diagnosis and allowed definitive pathological staging. Conclusion: This case highlights the aggressive biological behavior of rectal signet ring cell adenocarcinoma and underscores the importance of accurate diagnosis and a multidisciplinary management approach to optimize oncological outcomes in this rare histological variant. [ABSTRACT FROM AUTHOR]
ISSN:24524557
DOI:10.35687/s2452-454920260033017