Bibliographic Details
| Title: |
Asociaciones de granuloma anular: ¿factores de riesgo, causalidad o casualidad? |
| Alternate Title: |
Associations of granuloma annulare: Risk factors, causality, or coincidence? |
| Authors: |
Vázquez Medrano, Diana Alejandra1 dradianavazquezm@gmail.com, Cruz Quiñones, María Fernanda2, Rojas Urzúa, María Fernanda3, Alcántara Ramírez, Valerie Dafne4, Gutiérrez Ávila, Salvador Alonso5 |
| Source: |
Dermatología Revista Mexicana. mar/abr2026, Vol. 70 Issue 2, p233-242. 10p. |
| Subjects: |
Disease risk factors, Diabetes, Immune response, Granuloma, Causality (Physics), Cytokines, Smoking, Dyslipidemia |
| Abstract (English): |
BACKGROUND: Granuloma annulare has been linked to inflammatory, metabolic, and neoplastic disorders, without objectively determining whether this is a cause or an associated factor. OBJECTIVE: To determine the association of granuloma annulare with various comorbidities and its role as a risk factor and causal agent. METHODOLOGY: A bibliographic search was conducted in databases including PubMed, Scopus and Google Scholar. The search terms used were: "granuloma annulare", "diabetes", "dyslipidemia", "smoking" and "type IV hypersensitivity reaction", and combinations of operators (AND, OR). Observational studies, systematic reviews, and case reports published in the last six years were included. RESULTS: Granuloma annulare has a prevalence of 0.034% in dermatology consultations, with a higher incidence in the third decade of life and a female predominance (2:1 ratio). A significant association has been identified with diabetes mellitus (13-18%), hyperlipidemia (35%), hypothyroidism (15%), and autoimmune diseases. Smoking has been linked to a higher prevalence of granuloma annulare due to the induction of inflammatory cytokines. The activation of immune pathways, like JAK/STAT, and the involvement of Th1 and Th2 cells in pathogenesis have been documented. CONCLUSIONS: Granuloma annulare appears to be an immune-mediated condition influenced by various metabolic and inflammatory factors. Diabetes and dyslipidemia may act as risk factors, promoting delayed hypersensitivity activation. Smoking could play a role in granulomatous inflammation. However, a causal relationship between these conditions has not been established. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
ANTECEDENTES: El granuloma anular se ha vinculado con trastornos inflamatorios, metabólicos y neoplásicos, sin determinar objetivamente si ésta es una causa o un factor asociado. OBJETIVO: Determinar la asociación entre el granuloma anular y diversas comorbilidades, así como su papel como factor de riesgo y causalidad. METODOLOGÍA: Búsqueda bibliográfica en las bases de datos PubMed, Scopus y Google Scholar. Los términos de búsqueda fueron: granuloma annulare, diabetes, dyslipidemia, smoking, type IV hypersensitivity reaction, y combinaciones de operadores (AND, OR). Se incluyeron estudios observacionales, revisiones sistemáticas y reportes de casos publicados en los últimos seis años. RESULTADOS: El granuloma anular tiene una prevalencia del 0.034% en consultas dermatológicas, con mayor incidencia en la tercera década de la vida y predominio en mujeres (relación 2:1). Se identificó una asociación significativa con diabetes mellitus (13-18%), hiperlipidemia (35%), hipotiroidismo (15%) y enfermedades autoinmunitarias. El tabaquismo se ha vinculado con mayor prevalencia de granuloma anular, por la inducción de citocinas inflamatorias. Se ha documentado la activación de vías inmunológicas, como JAK/STAT, y la participación de células Th1 y Th2 en la patogénesis. CONCLUSIONES: El granuloma anular parece ser una enfermedad inmunomediada influenciada por diversos factores metabólicos e inflamatorios. La diabetes y la dislipidemia podrían actuar como factores de riesgo al favorecer la activación de la hipersensibilidad retardada. El tabaquismo podría desempeñar un papel en la inflamación granulomatosa. Sin embargo, no se establece una relación causal entre estas condiciones. [ABSTRACT FROM AUTHOR] |
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Copyright of Dermatología Revista Mexicana is the property of Edicion y Farmacia S.A. de C.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
MedicLatina |
